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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17860

FusionGeneSummary for ITGB1_ITGB1

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGB1_ITGB1
Fusion gene ID: 17860
HgeneTgene
Gene symbol

ITGB1

ITGB1

Gene ID

3688

3688

Gene nameintegrin subunit beta 1integrin subunit beta 1
SynonymsCD29|FNRB|GPIIA|MDF2|MSK12|VLA-BETA|VLABCD29|FNRB|GPIIA|MDF2|MSK12|VLA-BETA|VLAB
Cytomap

10p11.22

10p11.22

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-1glycoprotein IIaintegrin VLA-4 beta subunitintegrin beta 1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)very late activation protein, beta polypeptideintegrin beta-1glycoprotein IIaintegrin VLA-4 beta subunitintegrin beta 1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)very late activation protein, beta polypeptide
Modification date2018052320180523
UniProtAcc

P05556

P05556

Ensembl transtripts involved in fusion geneENST00000423113, ENST00000396033, 
ENST00000302278, ENST00000374956, 
ENST00000484088, 		ENST00000423113, 
ENST00000396033, ENST00000302278, 
ENST00000374956, ENST00000484088, 
Fusion gene scores* DoF score3 X 4 X 3=364 X 5 X 2=40
# samples 45
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ITGB1 [Title/Abstract] AND ITGB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGB1

GO:0007159

leukocyte cell-cell adhesion

1715889

HgeneITGB1

GO:0010710

regulation of collagen catabolic process

10455171

HgeneITGB1

GO:0033627

cell adhesion mediated by integrin

12807887|17158881

HgeneITGB1

GO:0051897

positive regulation of protein kinase B signaling

24044949

HgeneITGB1

GO:1903078

positive regulation of protein localization to plasma membrane

10455171

HgeneITGB1

GO:2000273

positive regulation of signaling receptor activity

24044949

TgeneITGB1

GO:0007159

leukocyte cell-cell adhesion

1715889

TgeneITGB1

GO:0010710

regulation of collagen catabolic process

10455171

TgeneITGB1

GO:0033627

cell adhesion mediated by integrin

12807887|17158881

TgeneITGB1

GO:0051897

positive regulation of protein kinase B signaling

24044949

TgeneITGB1

GO:1903078

positive regulation of protein localization to plasma membrane

10455171

TgeneITGB1

GO:2000273

positive regulation of signaling receptor activity

24044949


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG938602ITGB1chr10

33224487

+ITGB1chr10

33218980

-
ChiTaRS3.1AA852709ITGB1chr10

33221475

+ITGB1chr10

33218902

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000423113ENST00000423113ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000423113ENST00000396033ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000423113ENST00000302278ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000423113ENST00000374956ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000423113ENST00000484088ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000396033ENST00000423113ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000396033ENST00000396033ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000396033ENST00000302278ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000396033ENST00000374956ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000396033ENST00000484088ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000302278ENST00000423113ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000302278ENST00000396033ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000302278ENST00000302278ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000302278ENST00000374956ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000302278ENST00000484088ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000374956ENST00000423113ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000374956ENST00000396033ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000374956ENST00000302278ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000374956ENST00000374956ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000374956ENST00000484088ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000484088ENST00000423113ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000484088ENST00000396033ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000484088ENST00000302278ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000484088ENST00000374956ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-intronENST00000484088ENST00000484088ITGB1chr10

33224487

+ITGB1chr10

33218980

-
intron-3CDSENST00000423113ENST00000423113ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000423113ENST00000396033ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000423113ENST00000302278ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000423113ENST00000374956ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-5UTRENST00000423113ENST00000484088ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000396033ENST00000423113ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000396033ENST00000396033ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000396033ENST00000302278ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000396033ENST00000374956ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-5UTRENST00000396033ENST00000484088ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000302278ENST00000423113ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000302278ENST00000396033ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000302278ENST00000302278ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000302278ENST00000374956ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-5UTRENST00000302278ENST00000484088ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000374956ENST00000423113ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000374956ENST00000396033ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000374956ENST00000302278ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000374956ENST00000374956ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-5UTRENST00000374956ENST00000484088ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000484088ENST00000423113ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000484088ENST00000396033ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000484088ENST00000302278ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-3CDSENST00000484088ENST00000374956ITGB1chr10

33221475

+ITGB1chr10

33218902

-
intron-5UTRENST00000484088ENST00000484088ITGB1chr10

33221475

+ITGB1chr10

33218902

-

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FusionProtFeatures for ITGB1_ITGB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGB1

P05556

ITGB1

P05556


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ITGB1_ITGB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ITGB1_ITGB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ITGB1_ITGB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneITGB1P05556DB00098Antithymocyte immunoglobulin (rabbit)Integrin beta-1biotechapproved
TgeneITGB1P05556DB00098Antithymocyte immunoglobulin (rabbit)Integrin beta-1biotechapproved

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RelatedDiseases for ITGB1_ITGB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGB1C0006663Calcinosis1CTD_human
HgeneITGB1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneITGB1C0007137Squamous cell carcinoma1CTD_human
HgeneITGB1C0007193Cardiomyopathy, Dilated1CTD_human
HgeneITGB1C0014175Endometriosis1CTD_human
HgeneITGB1C0017639Gliosis1CTD_human
HgeneITGB1C0018801Heart failure1CTD_human
HgeneITGB1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneITGB1C0027626Neoplasm Invasiveness1CTD_human
HgeneITGB1C0027627Neoplasm Metastasis1CTD_human
HgeneITGB1C0878544Cardiomyopathies1CTD_human
TgeneITGB1C0006663Calcinosis1CTD_human
TgeneITGB1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneITGB1C0007137Squamous cell carcinoma1CTD_human
TgeneITGB1C0007193Cardiomyopathy, Dilated1CTD_human
TgeneITGB1C0014175Endometriosis1CTD_human
TgeneITGB1C0017639Gliosis1CTD_human
TgeneITGB1C0018801Heart failure1CTD_human
TgeneITGB1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneITGB1C0027626Neoplasm Invasiveness1CTD_human
TgeneITGB1C0027627Neoplasm Metastasis1CTD_human
TgeneITGB1C0878544Cardiomyopathies1CTD_human