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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17852

FusionGeneSummary for ITGAV_ARHGAP15

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGAV_ARHGAP15
Fusion gene ID: 17852
HgeneTgene
Gene symbol

ITGAV

ARHGAP15

Gene ID

3685

55843

Gene nameintegrin subunit alpha VRho GTPase activating protein 15
SynonymsCD51|MSK8|VNRA|VTNRBM046
Cytomap

2q32.1

2q22.2-q22.3

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-Vantigen identified by monoclonal antibody L230integrin alphaVbeta3integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)vitronectin receptor subunit alpharho GTPase-activating protein 15rho-type GTPase-activating protein 15
Modification date2018052020180523
UniProtAcc

P06756

Q53QZ3

Ensembl transtripts involved in fusion geneENST00000261023, ENST00000374907, 
ENST00000433736, ENST00000474571, 
ENST00000409869, ENST00000295095, 
ENST00000473426, 
Fusion gene scores* DoF score5 X 4 X 5=1009 X 8 X 5=360
# samples 59
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGAV [Title/Abstract] AND ARHGAP15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGAV

GO:0007155

cell adhesion

10218736

HgeneITGAV

GO:0008284

positive regulation of cell proliferation

19578119

HgeneITGAV

GO:0033627

cell adhesion mediated by integrin

12807887|17158881

HgeneITGAV

GO:0034446

substrate adhesion-dependent cell spreading

24658351

HgeneITGAV

GO:0045785

positive regulation of cell adhesion

10708943

HgeneITGAV

GO:0050764

regulation of phagocytosis

10570297

HgeneITGAV

GO:0070588

calcium ion transmembrane transport

18395422

HgeneITGAV

GO:2000536

negative regulation of entry of bacterium into host cell

10570297

TgeneARHGAP15

GO:0008360

regulation of cell shape

12650940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-VT-A80G-01AITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261023ENST00000409869ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
Frame-shiftENST00000261023ENST00000295095ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
5CDS-intronENST00000261023ENST00000473426ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
Frame-shiftENST00000374907ENST00000409869ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
Frame-shiftENST00000374907ENST00000295095ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
5CDS-intronENST00000374907ENST00000473426ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
Frame-shiftENST00000433736ENST00000409869ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
Frame-shiftENST00000433736ENST00000295095ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
5CDS-intronENST00000433736ENST00000473426ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
3UTR-3CDSENST00000474571ENST00000409869ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
3UTR-3CDSENST00000474571ENST00000295095ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+
3UTR-intronENST00000474571ENST00000473426ITGAVchr2

187534541

+ARHGAP15chr2

143986150

+

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FusionProtFeatures for ITGAV_ARHGAP15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGAV

P06756

ARHGAP15

Q53QZ3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ITGAV_ARHGAP15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ITGAV_ARHGAP15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ITGAVNOV, ILK, ITGB3, AUP1, L1CAM, CYR61, PLP1, MMP2, CSF1R, CBL, BCAR1, PHKA2, PXN, FBXO6, MCAT, KRT3, FN1, THBS1, EPHA2, TAZ, SUSD4, DPEP2, NTRK1, ITGB1, PSMD12, SPP1, LGALS3BP, FBXW7, MAPK3, NCOR1, NCOR2, EP300, MAPK1, STAT1, SHC1, PTK2, PLA2G2A, ADAM9, ERBB2, ANGPT2, NCL, PAK4, TNFSF13B, LYZL2, NAAA, DEFA1, ST3GAL1, GGH, TMEM25, ST8SIA4, TCTN2, INSL5, FCGR3B, EDIL3, FUT8, PTCH1, B3GNT2, UBC, ITGA4, ITGAV, ITGB5, AGMAT, TRIM25ARHGAP15RAC1, SNCA, PRNP, CD93, KDM1A, APP, DHPS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ITGAV_ARHGAP15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneITGAVP06756DB00098Antithymocyte immunoglobulin (rabbit)Integrin alpha-Vbiotechapproved

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RelatedDiseases for ITGAV_ARHGAP15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGAVC0038454Cerebrovascular accident1CTD_human
HgeneITGAVC2937358Cerebral Hemorrhage1CTD_human