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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17846

FusionGeneSummary for ITGA9_ZNF48

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGA9_ZNF48
Fusion gene ID: 17846
HgeneTgene
Gene symbol

ITGA9

ZNF48

Gene ID

3680

197407

Gene nameintegrin subunit alpha 9zinc finger protein 48
SynonymsALPHA-RLC|ITGA4L|RLCZNF553
Cytomap

3p22.2

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-9integrin alpha-RLCzinc finger protein 48zinc finger protein 553
Modification date2018051920180519
UniProtAcc

Q13797

Q96MX3

Ensembl transtripts involved in fusion geneENST00000264741, ENST00000422441, 
ENST00000320159, 
Fusion gene scores* DoF score6 X 6 X 7=2522 X 2 X 2=8
# samples 72
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ITGA9 [Title/Abstract] AND ZNF48 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTGCTTCGA-YU-AA4L-01AITGA9chr3

37584076

+ZNF48chr16

30407101

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264741ENST00000320159ITGA9chr3

37584076

+ZNF48chr16

30407101

+
5CDS-5UTRENST00000422441ENST00000320159ITGA9chr3

37584076

+ZNF48chr16

30407101

+

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FusionProtFeatures for ITGA9_ZNF48


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGA9

Q13797

ZNF48

Q96MX3

Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor forVCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. {ECO:0000250}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ITGA9_ZNF48


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ITGA9_ZNF48


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ITGA9ITGB1, ALDH1A3, LCN2, SERPINB4, SPRR1B, PCYOX1L, SMOC1, IGLL5, KLK10, IVL, HSPA5, CALML5, EVPL, IGKC, TUBA4AZNF48HIST1H1A, NIFK, HIST1H1E, RRP8, RBM34, CNBP, SART3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ITGA9_ZNF48


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ITGA9_ZNF48


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGA9C0005586Bipolar Disorder1PSYGENET
HgeneITGA9C1839839MAJOR AFFECTIVE DISORDER 21PSYGENET