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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17840

FusionGeneSummary for ITGA8_ITGA8

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGA8_ITGA8
Fusion gene ID: 17840
HgeneTgene
Gene symbol

ITGA8

ITGA8

Gene ID

8516

8516

Gene nameintegrin subunit alpha 8integrin subunit alpha 8
Synonyms--
Cytomap

10p13

10p13

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-8integrin, alpha 8integrin alpha-8integrin, alpha 8
Modification date2018051920180519
UniProtAcc

P53708

P53708

Ensembl transtripts involved in fusion geneENST00000378076, ENST00000477064, 
ENST00000378076, ENST00000477064, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 4=64
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGA8 [Title/Abstract] AND ITGA8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW794080ITGA8chr10

15756123

+ITGA8chr10

15755919

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000378076ENST00000378076ITGA8chr10

15756123

+ITGA8chr10

15755919

+
intron-intronENST00000378076ENST00000477064ITGA8chr10

15756123

+ITGA8chr10

15755919

+
intron-intronENST00000477064ENST00000378076ITGA8chr10

15756123

+ITGA8chr10

15755919

+
intron-intronENST00000477064ENST00000477064ITGA8chr10

15756123

+ITGA8chr10

15755919

+

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FusionProtFeatures for ITGA8_ITGA8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGA8

P53708

ITGA8

P53708

Integrin alpha-8/beta-1 functions in the genesis ofkidney and probably of other organs by regulating the recruitmentof mesenchymal cells into epithelial structures. It recognizes thesequence R-G-D in a wide array of ligands including TNC, FN1, SPP1TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand inkidney genesis. Neuronal receptor for TNC it mediates cell-cellinteractions and regulates neurite outgrowth of sensory and motorneurons. {ECO:0000269|PubMed:12415008,ECO:0000269|PubMed:15721307}. Integrin alpha-8/beta-1 functions in the genesis ofkidney and probably of other organs by regulating the recruitmentof mesenchymal cells into epithelial structures. It recognizes thesequence R-G-D in a wide array of ligands including TNC, FN1, SPP1TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand inkidney genesis. Neuronal receptor for TNC it mediates cell-cellinteractions and regulates neurite outgrowth of sensory and motorneurons. {ECO:0000269|PubMed:12415008,ECO:0000269|PubMed:15721307}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ITGA8_ITGA8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ITGA8_ITGA8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ITGA8_ITGA8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ITGA8_ITGA8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGA8C0036341Schizophrenia1PSYGENET
HgeneITGA8C0038356Stomach Neoplasms1CTD_human
HgeneITGA8C0919267ovarian neoplasm1CTD_human
HgeneITGA8C1619700RENAL ADYSPLASIA1HPO;UNIPROT
TgeneITGA8C0036341Schizophrenia1PSYGENET
TgeneITGA8C0038356Stomach Neoplasms1CTD_human
TgeneITGA8C0919267ovarian neoplasm1CTD_human
TgeneITGA8C1619700RENAL ADYSPLASIA1HPO;UNIPROT