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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17831

FusionGeneSummary for ITGA6_MYEOV

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGA6_MYEOV
Fusion gene ID: 17831
HgeneTgene
Gene symbol

ITGA6

MYEOV

Gene ID

3655

26579

Gene nameintegrin subunit alpha 6myeloma overexpressed
SynonymsCD49f|ITGA6B|VLA-6OCIM
Cytomap

2q31.1

11q13.3

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-6CD49 antigen-like family member Fintegrin alpha6Bintegrin, alpha 6myeloma-overexpressed gene proteinmyeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)myeloma overexpressed gene (in a subset of t(11;14) positive multiple myelomas)oncogene in multiple myeloma
Modification date2018052220180519
UniProtAcc

P23229

Q96EZ4

Ensembl transtripts involved in fusion geneENST00000409532, ENST00000264107, 
ENST00000343713, ENST00000264106, 
ENST00000375221, ENST00000409080, 
ENST00000441339, ENST00000308946, 
ENST00000535407, ENST00000541137, 
Fusion gene scores* DoF score6 X 4 X 5=12013 X 4 X 7=364
# samples 614
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/364*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGA6 [Title/Abstract] AND MYEOV [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-LN-A5U6-01AITGA6chr2

173292698

+MYEOVchr11

69156278

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000409532ENST00000441339ITGA6chr2

173292698

+MYEOVchr11

69156278

+
intron-intronENST00000409532ENST00000308946ITGA6chr2

173292698

+MYEOVchr11

69156278

+
intron-intronENST00000409532ENST00000535407ITGA6chr2

173292698

+MYEOVchr11

69156278

+
intron-3UTRENST00000409532ENST00000541137ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000264107ENST00000441339ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000264107ENST00000308946ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000264107ENST00000535407ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-3UTRENST00000264107ENST00000541137ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000343713ENST00000441339ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000343713ENST00000308946ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000343713ENST00000535407ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-3UTRENST00000343713ENST00000541137ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000264106ENST00000441339ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000264106ENST00000308946ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000264106ENST00000535407ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-3UTRENST00000264106ENST00000541137ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000375221ENST00000441339ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000375221ENST00000308946ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000375221ENST00000535407ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-3UTRENST00000375221ENST00000541137ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000409080ENST00000441339ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000409080ENST00000308946ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-intronENST00000409080ENST00000535407ITGA6chr2

173292698

+MYEOVchr11

69156278

+
5CDS-3UTRENST00000409080ENST00000541137ITGA6chr2

173292698

+MYEOVchr11

69156278

+

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FusionProtFeatures for ITGA6_MYEOV


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGA6

P23229

MYEOV

Q96EZ4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ITGA6_MYEOV


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ITGA6_MYEOV


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ITGA6GIPC1, TSPAN4, ITGB1, CD36, RABIF, BIN1, CALM1, APP, PDIA3, MOV10, NXF1, LGALS8, MCOLN3, HLA-C, B4GALT4, HLA-E, BTNL8, CANT1, PTCH1, PICK1, PON2, LGALS3BP, TMEM17, CDH1, CTDSPL, TSPAN11, PCDHGA5, TMPRSS11B, TMED6, HLA-DRB1, GML, PCDHB16, PCDH20, TRIM25MYEOVPRTFDC1, CNN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ITGA6_MYEOV


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ITGA6_MYEOV


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGA6C0003873Rheumatoid Arthritis1CTD_human