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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17830

FusionGeneSummary for ITGA6_HAT1

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGA6_HAT1
Fusion gene ID: 17830
HgeneTgene
Gene symbol

ITGA6

HAT1

Gene ID

3655

8520

Gene nameintegrin subunit alpha 6histone acetyltransferase 1
SynonymsCD49f|ITGA6B|VLA-6KAT1
Cytomap

2q31.1

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-6CD49 antigen-like family member Fintegrin alpha6Bintegrin, alpha 6histone acetyltransferase type B catalytic subunit
Modification date2018052220180523
UniProtAcc

P23229

O14929

Ensembl transtripts involved in fusion geneENST00000409532, ENST00000264107, 
ENST00000343713, ENST00000264106, 
ENST00000375221, ENST00000409080, 
ENST00000392584, ENST00000460481, 
ENST00000264108, 
Fusion gene scores* DoF score6 X 4 X 5=1202 X 2 X 2=8
# samples 62
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ITGA6 [Title/Abstract] AND HAT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHAT1

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

TgeneHAT1

GO:0006336

DNA replication-independent nucleosome assembly

14718166

TgeneHAT1

GO:0043967

histone H4 acetylation

22615379


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-7901-01AITGA6chr2

173292698

+HAT1chr2

172809399

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000409532ENST00000392584ITGA6chr2

173292698

+HAT1chr2

172809399

+
intron-intronENST00000409532ENST00000460481ITGA6chr2

173292698

+HAT1chr2

172809399

+
intron-intronENST00000409532ENST00000264108ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-5UTRENST00000264107ENST00000392584ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-intronENST00000264107ENST00000460481ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-intronENST00000264107ENST00000264108ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-5UTRENST00000343713ENST00000392584ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-intronENST00000343713ENST00000460481ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-intronENST00000343713ENST00000264108ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-5UTRENST00000264106ENST00000392584ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-intronENST00000264106ENST00000460481ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-intronENST00000264106ENST00000264108ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-5UTRENST00000375221ENST00000392584ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-intronENST00000375221ENST00000460481ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-intronENST00000375221ENST00000264108ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-5UTRENST00000409080ENST00000392584ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-intronENST00000409080ENST00000460481ITGA6chr2

173292698

+HAT1chr2

172809399

+
5CDS-intronENST00000409080ENST00000264108ITGA6chr2

173292698

+HAT1chr2

172809399

+

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FusionProtFeatures for ITGA6_HAT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGA6

P23229

HAT1

O14929

Acetylates soluble but not nucleosomal histone H4 at'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent,acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsicsubstrate specificity that modifies lysine in recognition sequenceGXGKXG. May be involved in nucleosome assembly during DNAreplication and repair as part of the histone H3.1 and H3.3complexes. May play a role in DNA repair in response to freeradical damage. {ECO:0000269|PubMed:11585814,ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379,ECO:0000269|PubMed:9427644}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ITGA6_HAT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ITGA6_HAT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ITGA6GIPC1, TSPAN4, ITGB1, CD36, RABIF, BIN1, CALM1, APP, PDIA3, MOV10, NXF1, LGALS8, MCOLN3, HLA-C, B4GALT4, HLA-E, BTNL8, CANT1, PTCH1, PICK1, PON2, LGALS3BP, TMEM17, CDH1, CTDSPL, TSPAN11, PCDHGA5, TMPRSS11B, TMED6, HLA-DRB1, GML, PCDHB16, PCDH20, TRIM25HAT1BAP1, G3BP1, ATG10, HIST1H4A, HIST3H3, RBBP7, ASF1B, IPO4, HIST1H3A, H3F3A, H2AFX, HIST1H3E, HIST4H4, BCL2A1, CUL3, COPS5, ACAA1, HIST2H4A, HIST2H2AC, TP53BP1, YWHAQ, ZGPAT, HSPA1A, MEOX2, RBBP4, REL, TCF4, TNFAIP1, RPS6KB2, UNK, C5orf51, AP2M1, DDI2, TTC4, VPS29, SNF8, TLN2, NTRK1, NASP, ASF1A, CRY2, FAM204A, VTN, PRKAA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ITGA6_HAT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ITGA6_HAT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGA6C0003873Rheumatoid Arthritis1CTD_human