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Fusion gene ID: 17826 |
FusionGeneSummary for ITGA4_UBE2E3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ITGA4_UBE2E3 | Fusion gene ID: 17826 | Hgene | Tgene | Gene symbol | ITGA4 | UBE2E3 | Gene ID | 3676 | 10477 |
| Gene name | integrin subunit alpha 4 | ubiquitin conjugating enzyme E2 E3 | |
| Synonyms | CD49D|IA4 | UBCH9|UbcM2 | |
| Cytomap | 2q31.3 | 2q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | integrin alpha-4269C wild typeCD49 antigen-like family member DVLA-4 subunit alphaalpha 4 subunit of VLA-4 receptorantigen CD49D, alpha-4 subunit of VLA-4 receptorintegrin alpha-IVvery late activation protein 4 receptor, alpha 4 subunit | ubiquitin-conjugating enzyme E2 E3E2 ubiquitin-conjugating enzyme E3ubiquitin carrier protein E3ubiquitin conjugating enzyme E2E 3ubiquitin-conjugating enzyme E2-23 kDaubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)ubiquitin-conjugating e | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P13612 | Q969T4 | |
| Ensembl transtripts involved in fusion gene | ENST00000339307, ENST00000397033, ENST00000478440, | ENST00000392415, ENST00000410062, ENST00000602710, ENST00000602837, ENST00000602959, ENST00000602475, ENST00000602632, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 6 X 5 X 5=150 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ITGA4 [Title/Abstract] AND UBE2E3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ITGA4 | GO:0007159 | leukocyte cell-cell adhesion | 1715889 |
| Hgene | ITGA4 | GO:0090074 | negative regulation of protein homodimerization activity | 12869515 |
| Tgene | UBE2E3 | GO:0070534 | protein K63-linked ubiquitination | 20061386 |
| Tgene | UBE2E3 | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
| Tgene | UBE2E3 | GO:0070979 | protein K11-linked ubiquitination | 20061386 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-X6-A8C3-01A | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000339307 | ENST00000392415 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-3CDS | ENST00000339307 | ENST00000410062 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-3CDS | ENST00000339307 | ENST00000602710 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-3UTR | ENST00000339307 | ENST00000602837 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-3UTR | ENST00000339307 | ENST00000602959 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-intron | ENST00000339307 | ENST00000602475 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-intron | ENST00000339307 | ENST00000602632 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| In-frame | ENST00000397033 | ENST00000392415 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| In-frame | ENST00000397033 | ENST00000410062 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| In-frame | ENST00000397033 | ENST00000602710 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| 5CDS-3UTR | ENST00000397033 | ENST00000602837 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| 5CDS-3UTR | ENST00000397033 | ENST00000602959 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| 5CDS-intron | ENST00000397033 | ENST00000602475 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| 5CDS-intron | ENST00000397033 | ENST00000602632 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-3CDS | ENST00000478440 | ENST00000392415 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-3CDS | ENST00000478440 | ENST00000410062 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-3CDS | ENST00000478440 | ENST00000602710 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-3UTR | ENST00000478440 | ENST00000602837 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-3UTR | ENST00000478440 | ENST00000602959 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-intron | ENST00000478440 | ENST00000602475 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
| intron-intron | ENST00000478440 | ENST00000602632 | ITGA4 | chr2 | 182347378 | + | UBE2E3 | chr2 | 181925392 | + |
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FusionProtFeatures for ITGA4_UBE2E3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ITGA4 | UBE2E3 |
| Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 arereceptors for fibronectin. They recognize one or more domainswithin the alternatively spliced CS-1 and CS-5 regions offibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes thesequence L-D-T in MADCAM1. On activated endothelial cells integrinVLA-4 triggers homotypic aggregation for most VLA-4-positiveleukocyte cell lines. It may also participate in cytolytic T-cellinteractions with target cells. ITGA4:ITGB1 binds to fractalkine(CX3CL1) and may act as its coreceptor in CX3CR1-dependentfractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds toPLA2G2A via a site (site 2) which is distinct from the classicalligand-binding site (site 1) and this induces integrinconformational changes and enhanced ligand binding to site 1(PubMed:18635536, PubMed:25398877). {ECO:0000269|PubMed:18635536,ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:23125415,ECO:0000269|PubMed:25398877}. | Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.Participates in the regulation of transepithelial sodium transportin renal cells. May be involved in cell growth arrest.{ECO:0000269|PubMed:10343118, ECO:0000269|PubMed:20061386}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ITGA4_UBE2E3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ITGA4_ENST00000397033_chr2_182347378_+_UBE2E3_ENST00000392415_chr2_181925392_+_429aa MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYR CRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRI APCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVG GAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSVTFRTRIYHCNIN >In-frame_ITGA4_ENST00000397033_chr2_182347378_+_UBE2E3_ENST00000410062_chr2_181925392_+_429aa MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYR CRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRI APCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVG GAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSVTFRTRIYHCNIN >In-frame_ITGA4_ENST00000397033_chr2_182347378_+_UBE2E3_ENST00000602710_chr2_181925392_+_429aa MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYR CRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRI APCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVG GAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSVTFRTRIYHCNIN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ITGA4_ENST00000397033_chr2_182347378_+_UBE2E3_ENST00000392415_chr2_181925392_+_1287nt ATGGCTTGGGAAGCGAGGCGCGAACCCGGCCCCCGAAGGGCCGCCGTCCGGGAGACGGTGATGCTGTTGCTGTGCCTGGGGGTCCCGACC GGCCGCCCCTACAACGTGGACACTGAGAGCGCGCTGCTTTACCAGGGCCCCCACAACACGCTGTTCGGCTACTCGGTCGTGCTGCACAGC CACGGGGCGAACCGATGGCTCCTAGTGGGTGCGCCCACTGCCAACTGGCTCGCCAACGCTTCAGTGATCAATCCCGGGGCGATTTACAGA TGCAGGATCGGAAAGAATCCCGGCCAGACGTGCGAACAGCTCCAGCTGGGTAGCCCTAATGGAGAACCTTGTGGAAAGACTTGTTTGGAA GAGAGAGACAATCAGTGGTTGGGGGTCACACTTTCCAGACAGCCAGGAGAAAATGGATCCATCGTGACTTGTGGGCATAGATGGAAAAAT ATATTTTACATAAAGAATGAAAATAAGCTCCCCACTGGTGGTTGCTATGGAGTGCCCCCTGATTTACGAACAGAACTGAGTAAAAGAATA GCTCCGTGTTATCAAGATTATGTGAAAAAATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCCAGTTTTTACACAAAGGATTTA ATTGTGATGGGGGCCCCAGGATCATCTTACTGGACTGGCTCTCTTTTTGTCTACAATATAACTACAAATAAATACAAGGCTTTTTTAGAC AAACAAAATCAAGTAAAATTTGGAAGTTATTTAGGATATTCAGTCGGAGCTGGTCATTTTCGGAGCCAGCATACTACCGAAGTAGTCGGA GGAGCTCCTCAACATGAGCAGATTGGTAAGGCATATATATTCAGCATTGATGAAAAAGAACTAAATATCTTACATGAAATGAAAGGTAAA AAGCTTGGATCGTACTTTGGAGCTTCTGTCTGTGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTGCTCGTGGGAGCACCCATGCAG AGCACCATCAGAGAGGAAGGAAGAGTGTTTGTGTACATCAACTCTGGCTCGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAAC AGTCAGGGAGTCATCTGTCTGGACATCCTTAAAGACAACTGGAGTCCCGCTTTGACTATTTCAAAGGTTTTGCTGTCTATTTGTTCCCTT TTGACAGACTGCAACCCTGCGGATCCTCTGGTTGGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACACGACAGGATAGCCAGA >In-frame_ITGA4_ENST00000397033_chr2_182347378_+_UBE2E3_ENST00000410062_chr2_181925392_+_1287nt ATGGCTTGGGAAGCGAGGCGCGAACCCGGCCCCCGAAGGGCCGCCGTCCGGGAGACGGTGATGCTGTTGCTGTGCCTGGGGGTCCCGACC GGCCGCCCCTACAACGTGGACACTGAGAGCGCGCTGCTTTACCAGGGCCCCCACAACACGCTGTTCGGCTACTCGGTCGTGCTGCACAGC CACGGGGCGAACCGATGGCTCCTAGTGGGTGCGCCCACTGCCAACTGGCTCGCCAACGCTTCAGTGATCAATCCCGGGGCGATTTACAGA TGCAGGATCGGAAAGAATCCCGGCCAGACGTGCGAACAGCTCCAGCTGGGTAGCCCTAATGGAGAACCTTGTGGAAAGACTTGTTTGGAA GAGAGAGACAATCAGTGGTTGGGGGTCACACTTTCCAGACAGCCAGGAGAAAATGGATCCATCGTGACTTGTGGGCATAGATGGAAAAAT ATATTTTACATAAAGAATGAAAATAAGCTCCCCACTGGTGGTTGCTATGGAGTGCCCCCTGATTTACGAACAGAACTGAGTAAAAGAATA GCTCCGTGTTATCAAGATTATGTGAAAAAATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCCAGTTTTTACACAAAGGATTTA ATTGTGATGGGGGCCCCAGGATCATCTTACTGGACTGGCTCTCTTTTTGTCTACAATATAACTACAAATAAATACAAGGCTTTTTTAGAC AAACAAAATCAAGTAAAATTTGGAAGTTATTTAGGATATTCAGTCGGAGCTGGTCATTTTCGGAGCCAGCATACTACCGAAGTAGTCGGA GGAGCTCCTCAACATGAGCAGATTGGTAAGGCATATATATTCAGCATTGATGAAAAAGAACTAAATATCTTACATGAAATGAAAGGTAAA AAGCTTGGATCGTACTTTGGAGCTTCTGTCTGTGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTGCTCGTGGGAGCACCCATGCAG AGCACCATCAGAGAGGAAGGAAGAGTGTTTGTGTACATCAACTCTGGCTCGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAAC AGTCAGGGAGTCATCTGTCTGGACATCCTTAAAGACAACTGGAGTCCCGCTTTGACTATTTCAAAGGTTTTGCTGTCTATTTGTTCCCTT TTGACAGACTGCAACCCTGCGGATCCTCTGGTTGGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACACGACAGGATAGCCAGA >In-frame_ITGA4_ENST00000397033_chr2_182347378_+_UBE2E3_ENST00000602710_chr2_181925392_+_1287nt ATGGCTTGGGAAGCGAGGCGCGAACCCGGCCCCCGAAGGGCCGCCGTCCGGGAGACGGTGATGCTGTTGCTGTGCCTGGGGGTCCCGACC GGCCGCCCCTACAACGTGGACACTGAGAGCGCGCTGCTTTACCAGGGCCCCCACAACACGCTGTTCGGCTACTCGGTCGTGCTGCACAGC CACGGGGCGAACCGATGGCTCCTAGTGGGTGCGCCCACTGCCAACTGGCTCGCCAACGCTTCAGTGATCAATCCCGGGGCGATTTACAGA TGCAGGATCGGAAAGAATCCCGGCCAGACGTGCGAACAGCTCCAGCTGGGTAGCCCTAATGGAGAACCTTGTGGAAAGACTTGTTTGGAA GAGAGAGACAATCAGTGGTTGGGGGTCACACTTTCCAGACAGCCAGGAGAAAATGGATCCATCGTGACTTGTGGGCATAGATGGAAAAAT ATATTTTACATAAAGAATGAAAATAAGCTCCCCACTGGTGGTTGCTATGGAGTGCCCCCTGATTTACGAACAGAACTGAGTAAAAGAATA GCTCCGTGTTATCAAGATTATGTGAAAAAATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCCAGTTTTTACACAAAGGATTTA ATTGTGATGGGGGCCCCAGGATCATCTTACTGGACTGGCTCTCTTTTTGTCTACAATATAACTACAAATAAATACAAGGCTTTTTTAGAC AAACAAAATCAAGTAAAATTTGGAAGTTATTTAGGATATTCAGTCGGAGCTGGTCATTTTCGGAGCCAGCATACTACCGAAGTAGTCGGA GGAGCTCCTCAACATGAGCAGATTGGTAAGGCATATATATTCAGCATTGATGAAAAAGAACTAAATATCTTACATGAAATGAAAGGTAAA AAGCTTGGATCGTACTTTGGAGCTTCTGTCTGTGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTGCTCGTGGGAGCACCCATGCAG AGCACCATCAGAGAGGAAGGAAGAGTGTTTGTGTACATCAACTCTGGCTCGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAAC AGTCAGGGAGTCATCTGTCTGGACATCCTTAAAGACAACTGGAGTCCCGCTTTGACTATTTCAAAGGTTTTGCTGTCTATTTGTTCCCTT TTGACAGACTGCAACCCTGCGGATCCTCTGGTTGGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACACGACAGGATAGCCAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ITGA4_ENST00000397033_chr2_182347378_+_UBE2E3_ENST00000392415_chr2_181925392_+_2252nt GCCATCCCGCGCTCTGCGGGCTGGGAGGCCCGGGCCAGGACGCGAGTCCTGCGCAGCCGAGGTTCCCCAGCGCCCCCTGCAGCCGCGCGT AGGCAGAGACGGAGCCCGGCCCTGCGCCTCCGCACCACGCCCGGGACCCCACCCAGCGGCCCGTACCCGGAGAAGCAGCGCGAGCACCCG AAGCTCCCGGCTGGCGGCAGAAACCGGGAGTGGGGCCGGGCGAGTGCGCGGCATCCCAGGCCGGCCCGAACGCTCCGCCCGCGGTGGGCC GACTTCCCCTCCTCTTCCCTCTCTCCTTCCTTTAGCCCGCTGGCGCCGGACACGCTGCGCCTCATCTCTTGGGGCGTTCTTCCCCGTTGG CCAACCGTCGCATCCCGTGCAACTTTGGGGTAGTGGCCGTTTAGTGTTGAATGTTCCCCACCGAGAGCGCATGGCTTGGGAAGCGAGGCG CGAACCCGGCCCCCGAAGGGCCGCCGTCCGGGAGACGGTGATGCTGTTGCTGTGCCTGGGGGTCCCGACCGGCCGCCCCTACAACGTGGA CACTGAGAGCGCGCTGCTTTACCAGGGCCCCCACAACACGCTGTTCGGCTACTCGGTCGTGCTGCACAGCCACGGGGCGAACCGATGGCT CCTAGTGGGTGCGCCCACTGCCAACTGGCTCGCCAACGCTTCAGTGATCAATCCCGGGGCGATTTACAGATGCAGGATCGGAAAGAATCC CGGCCAGACGTGCGAACAGCTCCAGCTGGGTAGCCCTAATGGAGAACCTTGTGGAAAGACTTGTTTGGAAGAGAGAGACAATCAGTGGTT GGGGGTCACACTTTCCAGACAGCCAGGAGAAAATGGATCCATCGTGACTTGTGGGCATAGATGGAAAAATATATTTTACATAAAGAATGA AAATAAGCTCCCCACTGGTGGTTGCTATGGAGTGCCCCCTGATTTACGAACAGAACTGAGTAAAAGAATAGCTCCGTGTTATCAAGATTA TGTGAAAAAATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCCAGTTTTTACACAAAGGATTTAATTGTGATGGGGGCCCCAGG ATCATCTTACTGGACTGGCTCTCTTTTTGTCTACAATATAACTACAAATAAATACAAGGCTTTTTTAGACAAACAAAATCAAGTAAAATT TGGAAGTTATTTAGGATATTCAGTCGGAGCTGGTCATTTTCGGAGCCAGCATACTACCGAAGTAGTCGGAGGAGCTCCTCAACATGAGCA GATTGGTAAGGCATATATATTCAGCATTGATGAAAAAGAACTAAATATCTTACATGAAATGAAAGGTAAAAAGCTTGGATCGTACTTTGG AGCTTCTGTCTGTGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTGCTCGTGGGAGCACCCATGCAGAGCACCATCAGAGAGGAAGG AAGAGTGTTTGTGTACATCAACTCTGGCTCGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAACAGTCAGGGAGTCATCTGTCT GGACATCCTTAAAGACAACTGGAGTCCCGCTTTGACTATTTCAAAGGTTTTGCTGTCTATTTGTTCCCTTTTGACAGACTGCAACCCTGC GGATCCTCTGGTTGGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACACGACAGGATAGCCAGACAGTGGACCAAGAGATACGC AACATAATTCACATAATTTGTATGCAGTGTGAAGGAGCAGAAGGCATCTTCTCACTGTGCTGCAAATCTTTATAGCCTTTACAATACGGA CTTCTGTGTATATGTTATACTGATTCTACTCTGCTTTTATCCTTTGGAGCCTGGGAGACTCCCCAAAAAGGTAAATGCTATCAAGAGTAG AACTTTGTAGCTGTAGATTAGTTATGTTTAAAACGCCTACTTGCAAGTCTTGCTTCTTTGGGATATCAAAATGTATTTTGTGATGTACTA AGGATACTGGTCCTGAAGTCTACCAAATATTATAGTGCATTTTAGCCTAATTCATTATCTGTATGAAGTTATAAAAGTAGCTGTAGATGG CTAGGAATTATGTCATTTGTATTAAACCCAGATCTATTTCTGAGTATGTGGTTCATGCTGTTGTGAAAAATGTTTTACCTTTTACCTTTG TCAGTTTGTAATGAGAGGATTTCCTTTTACCCTTTGTAGCTCAGAGAGCACCTGATGTATCATCTCAAACACAATAAACATGCTCCTGAA >In-frame_ITGA4_ENST00000397033_chr2_182347378_+_UBE2E3_ENST00000410062_chr2_181925392_+_2270nt GCCATCCCGCGCTCTGCGGGCTGGGAGGCCCGGGCCAGGACGCGAGTCCTGCGCAGCCGAGGTTCCCCAGCGCCCCCTGCAGCCGCGCGT AGGCAGAGACGGAGCCCGGCCCTGCGCCTCCGCACCACGCCCGGGACCCCACCCAGCGGCCCGTACCCGGAGAAGCAGCGCGAGCACCCG AAGCTCCCGGCTGGCGGCAGAAACCGGGAGTGGGGCCGGGCGAGTGCGCGGCATCCCAGGCCGGCCCGAACGCTCCGCCCGCGGTGGGCC GACTTCCCCTCCTCTTCCCTCTCTCCTTCCTTTAGCCCGCTGGCGCCGGACACGCTGCGCCTCATCTCTTGGGGCGTTCTTCCCCGTTGG CCAACCGTCGCATCCCGTGCAACTTTGGGGTAGTGGCCGTTTAGTGTTGAATGTTCCCCACCGAGAGCGCATGGCTTGGGAAGCGAGGCG CGAACCCGGCCCCCGAAGGGCCGCCGTCCGGGAGACGGTGATGCTGTTGCTGTGCCTGGGGGTCCCGACCGGCCGCCCCTACAACGTGGA CACTGAGAGCGCGCTGCTTTACCAGGGCCCCCACAACACGCTGTTCGGCTACTCGGTCGTGCTGCACAGCCACGGGGCGAACCGATGGCT CCTAGTGGGTGCGCCCACTGCCAACTGGCTCGCCAACGCTTCAGTGATCAATCCCGGGGCGATTTACAGATGCAGGATCGGAAAGAATCC CGGCCAGACGTGCGAACAGCTCCAGCTGGGTAGCCCTAATGGAGAACCTTGTGGAAAGACTTGTTTGGAAGAGAGAGACAATCAGTGGTT GGGGGTCACACTTTCCAGACAGCCAGGAGAAAATGGATCCATCGTGACTTGTGGGCATAGATGGAAAAATATATTTTACATAAAGAATGA AAATAAGCTCCCCACTGGTGGTTGCTATGGAGTGCCCCCTGATTTACGAACAGAACTGAGTAAAAGAATAGCTCCGTGTTATCAAGATTA TGTGAAAAAATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCCAGTTTTTACACAAAGGATTTAATTGTGATGGGGGCCCCAGG ATCATCTTACTGGACTGGCTCTCTTTTTGTCTACAATATAACTACAAATAAATACAAGGCTTTTTTAGACAAACAAAATCAAGTAAAATT TGGAAGTTATTTAGGATATTCAGTCGGAGCTGGTCATTTTCGGAGCCAGCATACTACCGAAGTAGTCGGAGGAGCTCCTCAACATGAGCA GATTGGTAAGGCATATATATTCAGCATTGATGAAAAAGAACTAAATATCTTACATGAAATGAAAGGTAAAAAGCTTGGATCGTACTTTGG AGCTTCTGTCTGTGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTGCTCGTGGGAGCACCCATGCAGAGCACCATCAGAGAGGAAGG AAGAGTGTTTGTGTACATCAACTCTGGCTCGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAACAGTCAGGGAGTCATCTGTCT GGACATCCTTAAAGACAACTGGAGTCCCGCTTTGACTATTTCAAAGGTTTTGCTGTCTATTTGTTCCCTTTTGACAGACTGCAACCCTGC GGATCCTCTGGTTGGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACACGACAGGATAGCCAGACAGTGGACCAAGAGATACGC AACATAATTCACATAATTTGTATGCAGTGTGAAGGAGCAGAAGGCATCTTCTCACTGTGCTGCAAATCTTTATAGCCTTTACAATACGGA CTTCTGTGTATATGTTATACTGATTCTACTCTGCTTTTATCCTTTGGAGCCTGGGAGACTCCCCAAAAAGGTAAATGCTATCAAGAGTAG AACTTTGTAGCTGTAGATTAGTTATGTTTAAAACGCCTACTTGCAAGTCTTGCTTCTTTGGGATATCAAAATGTATTTTGTGATGTACTA AGGATACTGGTCCTGAAGTCTACCAAATATTATAGTGCATTTTAGCCTAATTCATTATCTGTATGAAGTTATAAAAGTAGCTGTAGATGG CTAGGAATTATGTCATTTGTATTAAACCCAGATCTATTTCTGAGTATGTGGTTCATGCTGTTGTGAAAAATGTTTTACCTTTTACCTTTG TCAGTTTGTAATGAGAGGATTTCCTTTTACCCTTTGTAGCTCAGAGAGCACCTGATGTATCATCTCAAACACAATAAACATGCTCCTGAA >In-frame_ITGA4_ENST00000397033_chr2_182347378_+_UBE2E3_ENST00000602710_chr2_181925392_+_2270nt GCCATCCCGCGCTCTGCGGGCTGGGAGGCCCGGGCCAGGACGCGAGTCCTGCGCAGCCGAGGTTCCCCAGCGCCCCCTGCAGCCGCGCGT AGGCAGAGACGGAGCCCGGCCCTGCGCCTCCGCACCACGCCCGGGACCCCACCCAGCGGCCCGTACCCGGAGAAGCAGCGCGAGCACCCG AAGCTCCCGGCTGGCGGCAGAAACCGGGAGTGGGGCCGGGCGAGTGCGCGGCATCCCAGGCCGGCCCGAACGCTCCGCCCGCGGTGGGCC GACTTCCCCTCCTCTTCCCTCTCTCCTTCCTTTAGCCCGCTGGCGCCGGACACGCTGCGCCTCATCTCTTGGGGCGTTCTTCCCCGTTGG CCAACCGTCGCATCCCGTGCAACTTTGGGGTAGTGGCCGTTTAGTGTTGAATGTTCCCCACCGAGAGCGCATGGCTTGGGAAGCGAGGCG CGAACCCGGCCCCCGAAGGGCCGCCGTCCGGGAGACGGTGATGCTGTTGCTGTGCCTGGGGGTCCCGACCGGCCGCCCCTACAACGTGGA CACTGAGAGCGCGCTGCTTTACCAGGGCCCCCACAACACGCTGTTCGGCTACTCGGTCGTGCTGCACAGCCACGGGGCGAACCGATGGCT CCTAGTGGGTGCGCCCACTGCCAACTGGCTCGCCAACGCTTCAGTGATCAATCCCGGGGCGATTTACAGATGCAGGATCGGAAAGAATCC CGGCCAGACGTGCGAACAGCTCCAGCTGGGTAGCCCTAATGGAGAACCTTGTGGAAAGACTTGTTTGGAAGAGAGAGACAATCAGTGGTT GGGGGTCACACTTTCCAGACAGCCAGGAGAAAATGGATCCATCGTGACTTGTGGGCATAGATGGAAAAATATATTTTACATAAAGAATGA AAATAAGCTCCCCACTGGTGGTTGCTATGGAGTGCCCCCTGATTTACGAACAGAACTGAGTAAAAGAATAGCTCCGTGTTATCAAGATTA TGTGAAAAAATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCCAGTTTTTACACAAAGGATTTAATTGTGATGGGGGCCCCAGG ATCATCTTACTGGACTGGCTCTCTTTTTGTCTACAATATAACTACAAATAAATACAAGGCTTTTTTAGACAAACAAAATCAAGTAAAATT TGGAAGTTATTTAGGATATTCAGTCGGAGCTGGTCATTTTCGGAGCCAGCATACTACCGAAGTAGTCGGAGGAGCTCCTCAACATGAGCA GATTGGTAAGGCATATATATTCAGCATTGATGAAAAAGAACTAAATATCTTACATGAAATGAAAGGTAAAAAGCTTGGATCGTACTTTGG AGCTTCTGTCTGTGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTGCTCGTGGGAGCACCCATGCAGAGCACCATCAGAGAGGAAGG AAGAGTGTTTGTGTACATCAACTCTGGCTCGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAACAGTCAGGGAGTCATCTGTCT GGACATCCTTAAAGACAACTGGAGTCCCGCTTTGACTATTTCAAAGGTTTTGCTGTCTATTTGTTCCCTTTTGACAGACTGCAACCCTGC GGATCCTCTGGTTGGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACACGACAGGATAGCCAGACAGTGGACCAAGAGATACGC AACATAATTCACATAATTTGTATGCAGTGTGAAGGAGCAGAAGGCATCTTCTCACTGTGCTGCAAATCTTTATAGCCTTTACAATACGGA CTTCTGTGTATATGTTATACTGATTCTACTCTGCTTTTATCCTTTGGAGCCTGGGAGACTCCCCAAAAAGGTAAATGCTATCAAGAGTAG AACTTTGTAGCTGTAGATTAGTTATGTTTAAAACGCCTACTTGCAAGTCTTGCTTCTTTGGGATATCAAAATGTATTTTGTGATGTACTA AGGATACTGGTCCTGAAGTCTACCAAATATTATAGTGCATTTTAGCCTAATTCATTATCTGTATGAAGTTATAAAAGTAGCTGTAGATGG CTAGGAATTATGTCATTTGTATTAAACCCAGATCTATTTCTGAGTATGTGGTTCATGCTGTTGTGAAAAATGTTTTACCTTTTACCTTTG TCAGTTTGTAATGAGAGGATTTCCTTTTACCCTTTGTAGCTCAGAGAGCACCTGATGTATCATCTCAAACACAATAAACATGCTCCTGAA |
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FusionGenePPI for ITGA4_UBE2E3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ITGA4 | EED, PXN, CD81, PTK2, LGALS8, FN1, VCAM1, CLTC, PRKDC, FLNA, HNRNPM, HSPA8, TUBB4B, DDX5, ACTB, ACTG1, HSP90AB1, KHSRP, TLN1, PDCD6IP, CLIC1, HNRNPA2B1, VIM, HSPD1, RPS3, BUB3, PRDX1, AP2A1, VARS, EEF2, PABPC1, TUBA1C, KRT16, FUBP3, EEF1A1, EEF1A1P5, HBG1, HNRNPH3, KRT1, UBAP2L, CDK1, RPS18, PICALM, HSPB1, NSUN2, GAPDH, HNRNPK, HIST4H4, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, EIF4G1, PTBP1, HNRNPL, RPS4X, RPS14, TAGLN2, IGF2BP1, DDX3X, KRT6A, CAPN1, RBM4, RAN, PRPF8, EIF4G2, PARP1, NTPCR, RPS27A, UBA52, UBB, UBC, HIST1H2BL, HIST1H2BC, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI, HIST1H2BD, HIST1H2BH, HIST2H2BF, HIST1H2BM, HIST1H2BN, HIST1H1D, INPPL1, TCERG1, PCMT1, PCBP1, GCN1L1, GRB2, HNRNPU, SNRPD2, NUDT21, SNRNP200, RPS19, NUP214, ANXA1, RBM14, YWHAZ, PTPN23, HBA1, HBA2, PPIA, HNRNPH1, HBE1, HNRNPA1, HIST2H3C, HIST2H3D, HIST2H3A, H3F3B, H3F3A, HIST1H3B, HIST1H3F, HIST1H3E, HIST1H3H, HIST1H3G, HIST1H3C, HIST1H3D, HIST1H3I, H3F3AP6, HIST1H3A, HIST3H3, RPS3A, HNRNPC, IST1, EPRS, DDX21, HNRNPD, SDCBP, PFN1, IGF2BP2, AKR7A2, SFPQ, AP2B1, CLTA, PHB2, DNM2, CAD, NQO1, ACTN4, MCM5, RPS9, DYNC1H1, RPL11, CHMP4B, LARS, RPSA, LMNA, HIST1H2AE, HIST1H2AB, HIST1H2AG, HIST3H2A, HIST1H2AC, RAC2, KRT19, LRPPRC, RPL22, PPIL1, RPL23, HSPE1, RPL30, RPS5, APRT, RPL18, SYNCRIP, CCT7, EEF1D, RPS11, FERMT3, RPS21, PRDX2, HNRNPR, CCT6A, ATXN2L, PRDX6, RPS8, KRT8, RPS13, XPO5, SF1, EWSR1, CSNK2B, NCL, CCT4, FUBP1, CHMP2A, HNRNPA0, RPL12, CAPNS1, SRP9, RPS20, RPS16, CBL, SNX3, UPF1, RPS6, HBZ, KRT9, PCBP2, LYPLA1, HSPA1A, HSPA1B, CCT8, HIP1R, RPL13, PDCD6, FUS, HNRNPAB, RPLP0, ESYT1, RPL9, SLC25A5, XRCC6, LRRC59, TIAL1, IARS, SYK, MARS, RPL38, YWHAE, ILF2, HBG2, MBNL1, TOP2A, TARDBP, RPS15A, MIF, TOMM34, TTC9C, DAZAP1, RPS28, CFL1, MCM7, PPIH, ACTC1, PSMB1, VCP, ATP5I, PIN1, SRSF9, PUM1, RAB10, RPL23A, RPL26, CCT2, RPL35, STMN1, YBX1, CPSF7, PSMA7, LSM3, HSD17B10, STOM, RPS25, PSME3, CSE1L, DNAJC7, SNRPD1, EIF2S1, SNRPF, NDUFA2, RPL14, SDHB, RPL17, EFTUD2, DDX1, SND1, DDX17, PHB, HEATR1, EIF4E, FCGR2C, FCGR2A, RSL1D1, LDHA, PABPC4, DECR1, PFKP, ANKRD17, DRG1, RPS2, XRCC5, TCP1, SEC24C, EIF3K, ACP1, CCAR2, SDHA, VAPA, TTLL12, VAMP8, RPL10, MEMO1, MEMO1P1, G3BP1, PRRC2C, PYCR1, KPNB1, RPL10A, EIF3A, CD2AP, RPL27A, EEF1B2, RBM3, HNRNPA3, AP2S1, GSTK1, CCT3, TRIM28, HIST1H1C, RPL5, IQGAP1, PLEC, DDX39B, ATAD3A, KRT10, SRM, MYH10, RPL4, EIF4A3, DIMT1, PSMA6, ITGA4, PPP2R1A, FARSB, CCT5, ANXA2, SNRPA1, KRT18, NONO, EPS15, ARF5, MSN, NUP205, EIF4A1, NPM1, AP2M1, DHX15, ILF3, GSTP1, NUP93, RPL36, EIF3L, RBMX, PSMD2, PPP1CA, DARS, TFRC, TPR, PDCD10, XPO1, PSMB6, NHP2L1, VPS35, RAB5C, MCM6, RAC1, VDAC2, PSMA3, NAT10, HNRNPDL, MRPS23, MYH9, RPL13A, SMCHD1, LMNB1, TARS, PRDX3, EIF3E, IMMT, RPL7A, CHD4, STIP1, SNRPD3, MYL6, PIK3R2, ENO1, ARCN1, COPA, YARS, RPL28, CAPZB, ATP5O, ASNS, MCM4, NUP188, RPS7, RPS17, RPS24, CAPZA1, PSMD3, MYL12B, MYL12A, TYMS, HK2, SCRIB, RPL21, PPP2CA, PPP2CB, NUDC, CACYBP, ACO2, RCC1, NAPA, HP1BP3, CNBP, CYCS, NAA15, TIA1, UBR4, SNRNP70, NDUFS3, MYL4, ALYREF, PA2G4, SLC2A1, ATP5B, CSNK1A1, SSRP1, GLRX3, SEPT7, PI4KA, TNPO1, LONP1, STON2, PSMA1, ACAT1, MCM3, HIST1H1B, LDHB, TOP1, YWHAB, NUP210, LARP1, TUBB2A, TUBB2B, MDH2, PNP, PDHA1, MCM2, KPNA2, DDX42, EEF1E1, VCL, MLLT4, RAP1B, RAP2B, ANP32B, SRI, ARF1, ARF3, EPN1, UBE2NL, PSMB2, FBL, ALDOA, FLNB, RPS10, EIF3B, EIF3I, HNRNPF, ARPC4, UBE2M, AGFG1, LGALS1, YWHAG, IPO5, PAFAH1B3, SEC31A, BOLA2B, BOLA2, MAPRE1, PKM, MRPL43, UBL5, PFKL, ARPC3, RPL8, VASP, MATR3, ABCE1, HMGB1, LYPLA2, AARS, GMPS, SEC61B, SF3B6, LGALS9, BTNL8, PTCH1, PTPRK, NAAA, CST9, PON2, PRSS2, ST8SIA4, CPA2, FAM19A4, SCGB2A2, ITGAV, ITGB3 | UBE2E3 | RNF14, RNF8, SIAH1, UFM1, MUL1, CADPS2, CNOT4, RNF181, RMND5B, RNF111, RNF13, RNF130, RNF150, RNF165, RNF167, RNF25, RNF43, RNF115, ZNRF4, RNF5, ZNRF1, RNF114, RNF11, DTX3L, DZIP3, TRIM39, RNF10, RNF185, RNF2, RNF4, RING1, DTX3, CHFR, ARIH2, MID1, MKRN3, RFWD3, RNF166, TRIM2, TBL1XR1, TBL1X, STUB1, BRCA1, MID2, TRIM27, TRIM32, TRIM50, TRIM37, TRIM38, TRIM45, DDA1, DET1, DDB1, UBA1, IPO11, NFE2L2, UBE2E3, UBC, ARID3A, CUL3, RCBTB1, RCBTB2, KLHL42, SPOP, CUL1, CUL4A, ATXN1, HERC4, NEDD4L, WWP2, ITCH, BARD1, MDM2, HTT, TARDBP, MARCH5, RBX1, RANGAP1, FBXO25, CCDC121, FSD1, NKD2, RDH12, SPRY2, ETV5, RC3H2, OTUB1, DTL, PECR, USP15, UBB, RNF220, TOPORS, PCGF3, USP7, CSNK2A2, FBRS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ITGA4_UBE2E3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ITGA4 | P13612 | DB06822 | Tinzaparin | Integrin alpha-4 | small molecule | approved |
| Hgene | ITGA4 | P13612 | DB09033 | Vedolizumab | Integrin alpha-4 | biotech | approved |
| Hgene | ITGA4 | P13612 | DB00108 | Natalizumab | Integrin alpha-4 | biotech | approved|investigational |
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RelatedDiseases for ITGA4_UBE2E3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ITGA4 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Hgene | ITGA4 | C0017639 | Gliosis | 1 | CTD_human |
| Hgene | ITGA4 | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
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