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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17808

FusionGeneSummary for ITGA1_PKIB

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGA1_PKIB
Fusion gene ID: 17808
HgeneTgene
Gene symbol

ITGA1

PKIB

Gene ID

3672

5570

Gene nameintegrin subunit alpha 1cAMP-dependent protein kinase inhibitor beta
SynonymsCD49a|VLA1PRKACN2
Cytomap

5q11.2

6q22.31

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-1CD49 antigen-like family member AVLA-1laminin and collagen receptorvery late activation protein 1cAMP-dependent protein kinase inhibitor betaPKI-betacAMP-dependent protein kinase inhibitor 2protein kinase (cAMP-dependent, catalytic) inhibitor beta
Modification date2018052220180523
UniProtAcc

P56199

Q9C010

Ensembl transtripts involved in fusion geneENST00000282588, ENST00000504086, 
ENST00000392491, ENST00000607474, 
ENST00000368452, ENST00000368448, 
ENST00000392490, ENST00000258014, 
ENST00000354275, ENST00000368446, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 4 X 5=120
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGA1 [Title/Abstract] AND PKIB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGA1

GO:0032516

positive regulation of phosphoprotein phosphatase activity

15592458


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV416658ITGA1chr5

52153457

-PKIBchr6

123029346

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000282588ENST00000392491ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000282588ENST00000607474ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000282588ENST00000368452ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000282588ENST00000368448ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000282588ENST00000392490ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000282588ENST00000258014ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000282588ENST00000354275ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000282588ENST00000368446ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000504086ENST00000392491ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000504086ENST00000607474ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000504086ENST00000368452ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000504086ENST00000368448ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000504086ENST00000392490ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000504086ENST00000258014ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000504086ENST00000354275ITGA1chr5

52153457

-PKIBchr6

123029346

+
intron-intronENST00000504086ENST00000368446ITGA1chr5

52153457

-PKIBchr6

123029346

+

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FusionProtFeatures for ITGA1_PKIB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGA1

P56199

PKIB

Q9C010

Integrin alpha-1/beta-1 is a receptor for laminin andcollagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negativeregulation of EGF-stimulated cell growth.{ECO:0000269|PubMed:15592458}. Extremely potent competitive inhibitor of cAMP-dependentprotein kinase activity, this protein interacts with the catalyticsubunit of the enzyme after the cAMP-induced dissociation of itsregulatory chains. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ITGA1_PKIB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ITGA1_PKIB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ITGA1_PKIB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ITGA1_PKIB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGA1C0017639Gliosis1CTD_human