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Fusion gene ID: 17777 |
FusionGeneSummary for ISYNA1_PABPC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ISYNA1_PABPC1 | Fusion gene ID: 17777 | Hgene | Tgene | Gene symbol | ISYNA1 | PABPC1 | Gene ID | 51477 | 26986 |
| Gene name | inositol-3-phosphate synthase 1 | poly(A) binding protein cytoplasmic 1 | |
| Synonyms | INO1|INOS|IPS|IPS 1|IPS-1 | PAB1|PABP|PABP1|PABPC2|PABPL1 | |
| Cytomap | 19p13.11 | 8q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inositol-3-phosphate synthase 1MI-1-P synthaseMIP synthasemyo-inositol 1-phosphate synthase A1testis secretory sperm-binding protein Li 200a | polyadenylate-binding protein 1poly(A) binding protein, cytoplasmic 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NPH2 | P11940 | |
| Ensembl transtripts involved in fusion gene | ENST00000545187, ENST00000338128, ENST00000457269, ENST00000578963, ENST00000317018, | ENST00000318607, ENST00000519004, ENST00000522387, ENST00000519596, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 7 X 8 X 3=168 |
| # samples | 5 | 8 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ISYNA1 [Title/Abstract] AND PABPC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PABPC1 | GO:2000623 | negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 18447585 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-DK-A1A6-01A | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000545187 | ENST00000318607 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| intron-3CDS | ENST00000545187 | ENST00000519004 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| intron-3CDS | ENST00000545187 | ENST00000522387 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| intron-intron | ENST00000545187 | ENST00000519596 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-3CDS | ENST00000338128 | ENST00000318607 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-3CDS | ENST00000338128 | ENST00000519004 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-3CDS | ENST00000338128 | ENST00000522387 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-intron | ENST00000338128 | ENST00000519596 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-3CDS | ENST00000457269 | ENST00000318607 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-3CDS | ENST00000457269 | ENST00000519004 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-3CDS | ENST00000457269 | ENST00000522387 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-intron | ENST00000457269 | ENST00000519596 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| intron-3CDS | ENST00000578963 | ENST00000318607 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| intron-3CDS | ENST00000578963 | ENST00000519004 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| intron-3CDS | ENST00000578963 | ENST00000522387 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| intron-intron | ENST00000578963 | ENST00000519596 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-3CDS | ENST00000317018 | ENST00000318607 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-3CDS | ENST00000317018 | ENST00000519004 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-3CDS | ENST00000317018 | ENST00000522387 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
| 5UTR-intron | ENST00000317018 | ENST00000519596 | ISYNA1 | chr19 | 18548903 | - | PABPC1 | chr8 | 101721451 | - |
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FusionProtFeatures for ISYNA1_PABPC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ISYNA1 | PABPC1 |
| Binds the poly(A) tail of mRNA, including that of itsown transcript. May be involved in cytoplasmic regulatoryprocesses of mRNA metabolism such as pre-mRNA splicing. Itsfunction in translational initiation regulation can either beenhanced by PAIP1 or repressed by PAIP2. Can probably bind tocytoplasmic RNA sequences other than poly(A) in vivo. Involved intranslationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translationaland decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved inregulation of nonsense-mediated decay (NMD) of mRNAs containingpremature stop codons; for the recognition of prematuretermination codons (PTC) and initiation of NMD a competitiveinteraction between UPF1 and PABPC1 with the ribosome-boundrelease factors is proposed. By binding to long poly(A) tails, mayprotect them from uridylation by ZCCHC6/ZCCHC11 and hencecontribute to mRNA stability (PubMed:25480299). Positivelyregulates the replication of dengue virus (DENV)(PubMed:26735137). {ECO:0000269|PubMed:11051545,ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585,ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299,ECO:0000269|PubMed:26735137}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ISYNA1_PABPC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ISYNA1_PABPC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ISYNA1 | PPP2CA, POT1, DUSP14, TRAF4, ABCE1, FBXW11, ACAA2, ALDOA, ARHGDIA, ECHS1, ERN2, HNRNPH2, ACE2, ALDOC, CYB5A, CYB5B, DLD, EEF2, EZR, GLRX3, HSD17B10, MSN, RDX, SUMO3, TPD52L1, VCP, NACA2, PGD, PLS1, PPIB, PREP, PSMD9, UCHL3, NTRK1, CDH1, TRIM25 | PABPC1 | ANAPC5, EIF4A2, IKBKE, PINX1, DYNLL1, PUF60, BCAR3, PAN2, UPF1, ETF1, PAN3, CNOT7, TOB1, EIF4B, PXN, PAIP1, GNB2L1, PAIP2, EIF4A1, GSPT2, GSPT1, EIF4G1, EIF4G3, HNRNPA1, AIRE, GIGYF2, H2AFX, PRMT6, HNRNPD, HDAC5, STAU1, HNRNPK, YWHAG, PCBP1, PCBP2, SREK1, NDRG1, ELAVL1, ARRB2, SIRT7, ZFP36, NCL, SH3KBP1, TSG101, TNRC6A, TNRC6B, TNRC6C, ATXN2, IGBP1, PPP2CA, NFX1, PABPC1, UBR5, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, CHAF1A, CNOT6, TOB2, MEX3B, MEX3A, MEX3C, BRCA1, SMAD3, PAIP2B, FBXO6, SYNCRIP, HNRNPU, HNRNPR, SNRNP200, DHX15, SNW1, ILF3, EEF1A1, RPS21, RPS4X, RPSA, RPS28, RPL4, RPL7, RPL7A, RPL13, RALY, SNRPD3, SART1, PRPF3, SNRPA, RPL5, EEF2, ATP6V1B2, ATP5A1, ESR1, HBB, USP10, G3BP1, FN1, VCAM1, U2AF1, RBM4, IFIT1, IFIT2, IFIT3, AGO1, AGO2, IL7R, UBL4A, ITGA4, MAPKAPK2, SMG1, RBM8A, CD81, IGSF8, ICAM1, RUVBL1, TERT, BAG3, CSF2, TARDBP, CLK3, SRPK2, SRPK1, CLK2, ITCH, WBP4, APBB1, PIN1, WWOX, APEX1, P4HB, GNPDA1, SGTA, UBA1, PSMD9, TMOD3, RPA1, RPA2, RPA3, HAUS1, CEP250, TP53, WWP2, SMG6, R3HCC1L, TDRD3, CUL7, OBSL1, CCDC8, ZMYND11, FBXW11, MAEL, ACAT2, CSTF2, DDX19A, EEF1G, FDPS, G3BP2, HSPA8, KIN, LUC7L2, MIF, MSI2, NHP2L1, ORC4, ALYREF, ATXN2L, BRIX1, CSTF3, DDX39A, DDX39B, EEF1A2, EIF4E, PFAS, PHGDH, POLE, RAE1, RPL13A, RPL18, RPL35, SFN, SKIV2L2, UAP1, PAPOLA, PAPOLB, PDCD6, PLRG1, PREP, PRPF8, RPL10A, RPL11, RPL14, RPL15, RPL17, RPL18A, RPL27, RPL27A, RPL3, RPL37A, RPL39, RPL6, RPLP0, RPLP2, RPS16, RPS3A, RPS6, RPS8, SERBP1, SF3A1, SUMO1, NTRK1, XPO1, HIST1H3E, RPL10, GAN, SKI, CRY1, MKRN1, MCM2, U2AF2, ELAVL2, TRA2A, SNRNP70, CYLD, COX15, DLD, DLST, DNM1L, HSD17B10, PARK7, PDHA1, VDAC1, TRIM25, PRNP, DCAF4L2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ISYNA1_PABPC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ISYNA1 | Q9NPH2 | DB09462 | Glycerin | Inositol-3-phosphate synthase 1 | small molecule | approved|investigational |
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RelatedDiseases for ISYNA1_PABPC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ISYNA1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | ISYNA1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | ISYNA1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| Hgene | ISYNA1 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
| Tgene | PABPC1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | PABPC1 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Tgene | PABPC1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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