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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17775

FusionGeneSummary for ISYNA1_CSH2

check button Fusion gene summary
Fusion gene informationFusion gene name: ISYNA1_CSH2
Fusion gene ID: 17775
HgeneTgene
Gene symbol

ISYNA1

CSH2

Gene ID

51477

1443

Gene nameinositol-3-phosphate synthase 1chorionic somatomammotropin hormone 2
SynonymsINO1|INOS|IPS|IPS 1|IPS-1CS-2|CSB|GHB1|PL|hCS-B
Cytomap

19p13.11

17q23.3

Type of geneprotein-codingprotein-coding
Descriptioninositol-3-phosphate synthase 1MI-1-P synthaseMIP synthasemyo-inositol 1-phosphate synthase A1testis secretory sperm-binding protein Li 200achorionic somatomammotropin hormone 2choriomammotropinchorionic somatomammotropin Bgrowth hormone B1lactogenplacental lactogen
Modification date2018052320180523
UniProtAcc

Q9NPH2

Ensembl transtripts involved in fusion geneENST00000545187, ENST00000338128, 
ENST00000457269, ENST00000578963, 
ENST00000317018, 
ENST00000345366, 
ENST00000336844, ENST00000392886, 
ENST00000560142, 
Fusion gene scores* DoF score5 X 4 X 3=605 X 5 X 2=50
# samples 55
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: ISYNA1 [Title/Abstract] AND CSH2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA368753ISYNA1chr19

18547190

-CSH2chr17

61951036

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000545187ENST00000345366ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000545187ENST00000336844ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000545187ENST00000392886ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000545187ENST00000560142ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000338128ENST00000345366ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000338128ENST00000336844ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000338128ENST00000392886ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000338128ENST00000560142ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000457269ENST00000345366ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000457269ENST00000336844ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000457269ENST00000392886ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000457269ENST00000560142ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000578963ENST00000345366ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000578963ENST00000336844ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000578963ENST00000392886ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000578963ENST00000560142ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000317018ENST00000345366ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000317018ENST00000336844ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000317018ENST00000392886ISYNA1chr19

18547190

-CSH2chr17

61951036

-
intron-5UTRENST00000317018ENST00000560142ISYNA1chr19

18547190

-CSH2chr17

61951036

-

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FusionProtFeatures for ISYNA1_CSH2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ISYNA1

Q9NPH2

CSH2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ISYNA1_CSH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ISYNA1_CSH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ISYNA1_CSH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneISYNA1Q9NPH2DB09462GlycerinInositol-3-phosphate synthase 1small moleculeapproved|investigational

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RelatedDiseases for ISYNA1_CSH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneISYNA1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneISYNA1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneISYNA1C0032460Polycystic Ovary Syndrome1CTD_human
HgeneISYNA1C0036095Salivary Gland Neoplasms1CTD_human