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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17758

FusionGeneSummary for ISG20_TBCC

check button Fusion gene summary
Fusion gene informationFusion gene name: ISG20_TBCC
Fusion gene ID: 17758
HgeneTgene
Gene symbol

ISG20

TBCC

Gene ID

3669

6903

Gene nameinterferon stimulated exonuclease gene 20tubulin folding cofactor C
SynonymsCD25|HEM45CFC
Cytomap

15q26.1

6p21.1

Type of geneprotein-codingprotein-coding
Descriptioninterferon-stimulated gene 20 kDa proteinestrogen-regulated transcript 45 proteininterferon stimulated exonuclease gene 20kDapromyelocytic leukemia nuclear body-associated protein ISG20tubulin-specific chaperone C
Modification date2018051920180523
UniProtAcc

Q96AZ6

Q15814

Ensembl transtripts involved in fusion geneENST00000560741, ENST00000306072, 
ENST00000379224, ENST00000560746, 
ENST00000372876, ENST00000244625, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ISG20 [Title/Abstract] AND TBCC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneISG20

GO:0000738

DNA catabolic process, exonucleolytic

11401564

HgeneISG20

GO:0006401

RNA catabolic process

11401564

HgeneISG20

GO:0009615

response to virus

12594219

TgeneTBCC

GO:0007023

post-chaperonin tubulin folding pathway

11847227


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ052721ISG20chr15

89182642

+TBCCchr6

42713713

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000560741ENST00000372876ISG20chr15

89182642

+TBCCchr6

42713713

-
In-frameENST00000560741ENST00000244625ISG20chr15

89182642

+TBCCchr6

42713713

-
Frame-shiftENST00000306072ENST00000372876ISG20chr15

89182642

+TBCCchr6

42713713

-
In-frameENST00000306072ENST00000244625ISG20chr15

89182642

+TBCCchr6

42713713

-
Frame-shiftENST00000379224ENST00000372876ISG20chr15

89182642

+TBCCchr6

42713713

-
In-frameENST00000379224ENST00000244625ISG20chr15

89182642

+TBCCchr6

42713713

-
intron-3CDSENST00000560746ENST00000372876ISG20chr15

89182642

+TBCCchr6

42713713

-
intron-3CDSENST00000560746ENST00000244625ISG20chr15

89182642

+TBCCchr6

42713713

-

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FusionProtFeatures for ISG20_TBCC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ISG20

Q96AZ6

TBCC

Q15814

Interferon-induced antiviral exoribonuclease that actson single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA virusesincluding hepatitis C virus (HCV), hepatitis A virus (HAV) andyellow fever virus (YFV) in an exonuclease-dependent manner. Mayalso play additional roles in the maturation of snRNAs and rRNAs,and in ribosome biogenesis. {ECO:0000269|PubMed:11401564,ECO:0000269|PubMed:12594219, ECO:0000269|PubMed:16033969,ECO:0000269|PubMed:21036379}. Tubulin-folding protein; involved in the final step ofthe tubulin folding pathway. {ECO:0000269|PubMed:11847227}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ISG20_TBCC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ISG20_ENST00000560741_chr15_89182642_+_TBCC_ENST00000244625_chr6_42713713_-_0aa

>In-frame_ISG20_ENST00000306072_chr15_89182642_+_TBCC_ENST00000244625_chr6_42713713_-_0aa

>In-frame_ISG20_ENST00000379224_chr15_89182642_+_TBCC_ENST00000244625_chr6_42713713_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ISG20_ENST00000560741_chr15_89182642_+_TBCC_ENST00000244625_chr6_42713713_-_0nt

>In-frame_ISG20_ENST00000306072_chr15_89182642_+_TBCC_ENST00000244625_chr6_42713713_-_0nt

>In-frame_ISG20_ENST00000379224_chr15_89182642_+_TBCC_ENST00000244625_chr6_42713713_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_ISG20_ENST00000560741_chr15_89182642_+_TBCC_ENST00000244625_chr6_42713713_-_0nt

>In-frame_ISG20_ENST00000306072_chr15_89182642_+_TBCC_ENST00000244625_chr6_42713713_-_0nt

>In-frame_ISG20_ENST00000379224_chr15_89182642_+_TBCC_ENST00000244625_chr6_42713713_-_0nt


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FusionGenePPI for ISG20_TBCC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ISG20_TBCC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ISG20_TBCC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneISG20C0023893Liver Cirrhosis, Experimental1CTD_human