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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17740

FusionGeneSummary for IRF9_RNF31

check button Fusion gene summary
Fusion gene informationFusion gene name: IRF9_RNF31
Fusion gene ID: 17740
HgeneTgene
Gene symbol

IRF9

RNF31

Gene ID

10379

55072

Gene nameinterferon regulatory factor 9ring finger protein 31
SynonymsIRF-9|ISGF3|ISGF3G|p48HOIP|Paul|ZIBRA
Cytomap

14q12

14q12

Type of geneprotein-codingprotein-coding
Descriptioninterferon regulatory factor 9IFN-alpha-responsive transcription factor subunitISGF-3 gammaISGF3 p48 subunitinterferon-stimulated gene factor 3 gammainterferon-stimulated transcription factor 3, gamma (48kD)interferon-stimulated transcription factorE3 ubiquitin-protein ligase RNF31HOIL-1-interacting proteinRING-type E3 ubiquitin transferase RNF31zinc in-between-RING-finger ubiquitin-associated domain protein
Modification date2018051920180527
UniProtAcc

Q00978

Q96EP0

Ensembl transtripts involved in fusion geneENST00000396864, ENST00000557894, 
ENST00000557878, ENST00000559275, 
ENST00000324103, ENST00000382687, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 4=100
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IRF9 [Title/Abstract] AND RNF31 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRNF31

GO:0000209

protein polyubiquitination

12629548|17006537

TgeneRNF31

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19136968|21455173

TgeneRNF31

GO:0050852

T cell receptor signaling pathway

20005846

TgeneRNF31

GO:0051092

positive regulation of NF-kappaB transcription factor activity

19136968

TgeneRNF31

GO:0097039

protein linear polyubiquitination

21455173|21455180|21455181|23453807


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-BC-A8YO-01AIRF9chr14

24631533

+RNF31chr14

24629448

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000396864ENST00000557878IRF9chr14

24631533

+RNF31chr14

24629448

+
5CDS-intronENST00000396864ENST00000559275IRF9chr14

24631533

+RNF31chr14

24629448

+
5CDS-intronENST00000396864ENST00000324103IRF9chr14

24631533

+RNF31chr14

24629448

+
5CDS-intronENST00000396864ENST00000382687IRF9chr14

24631533

+RNF31chr14

24629448

+
intron-intronENST00000557894ENST00000557878IRF9chr14

24631533

+RNF31chr14

24629448

+
intron-intronENST00000557894ENST00000559275IRF9chr14

24631533

+RNF31chr14

24629448

+
intron-intronENST00000557894ENST00000324103IRF9chr14

24631533

+RNF31chr14

24629448

+
intron-intronENST00000557894ENST00000382687IRF9chr14

24631533

+RNF31chr14

24629448

+

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FusionProtFeatures for IRF9_RNF31


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IRF9

Q00978

RNF31

Q96EP0

Transcription factor that mediates signaling by type IIFNs (IFN-alpha and IFN-beta). Following type I IFN binding tocell surface receptors, Jak kinases (TYK2 and JAK1) are activated,leading to tyrosine phosphorylation of STAT1 and STAT2.IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimerto form a complex termed ISGF3 transcription factor, that entersthe nucleus. ISGF3 binds to the IFN stimulated response element(ISRE) to activate the transcription of interferon stimulatedgenes, which drive the cell in an antiviral state. E3 ubiquitin-protein ligase component of the LUBACcomplex which conjugates linear ('Met-1'-linked) polyubiquitinchains to substrates and plays a key role in NF-kappa-B activationand regulation of inflammation (PubMed:17006537, PubMed:19136968,PubMed:20005846, PubMed:21455173, PubMed:21455180,PubMed:21455181, PubMed:22863777). LUBAC conjugates linearpolyubiquitin to IKBKG and RIPK1 and is involved in activation ofthe canonical NF-kappa-B and the JNK signaling pathways(PubMed:17006537, PubMed:19136968, PubMed:20005846,PubMed:21455173, PubMed:21455180, PubMed:21455181,PubMed:22863777). Linear ubiquitination mediated by the LUBACcomplex interferes with TNF-induced cell death and therebyprevents inflammation (PubMed:21455173). LUBAC is proposed to berecruited to the TNF-R1 signaling complex (TNF-RSC) followingpolyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 andto conjugate linear polyubiquitin to IKBKG and possibly othercomponents contributing to the stability of the complex(PubMed:20005846). Together with otulin, the LUBAC complexregulates the canonical Wnt signaling during angiogenesis. Bindspolyubiquitin of different linkage types (PubMed:23708998).{ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968,ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173,ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181,ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IRF9_RNF31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IRF9_RNF31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IRF9STAT1, STAT2, NFKB1, RELA, TLX2, HOXC9, IRF1, POU2F1, NR2E3, ARID3B, VENTX, TLX3, DMRTC2, DACH2, IFNAR2, CREBBP, ELAVL1, DNMT3A, IRF2BP1, TOP1, MYO1F, S100A13, FOXL1, RAD18, ANKHD1-EIF4EBP3, UBE2R2, ARIH1, FBLN1, ANKHD1, ANKRD17RNF31TNF, RBCK1, ATXN7, AZI2, TRAF1, TRIM25, DDX58, NOD2, RIPK2, NR0B1, NR0B2, PRKCB, ATN1, ATXN1, GFI1B, TNFAIP3, IKBKG, SHARPIN, UBE2D1, UBE2D3, NOS3, BIRC2, BIRC3, UBC, OTULIN, SMAD3, SOCS3, VCP, NDUFA8, TRAF2, CCDC14, WRNIP1, AKAP8L, ESR1, RNF31, IRAK1, MALT1, KIF1A, PITX1, PRKCA, AES, SNRPC, TSSC4, KRTAP9-2, VASN, CCDC24, UBE2D2, UBE2L3, CD40, ENDOV, ARHGEF10, PPARD, LIPF, LTBR, LDLRAD4, NTRK1, CYLD, RIPK1, TNFRSF1A, PDLIM7, IRF7, CARD11, BCL10, TLR3, SPATA2, LMO2, RABGEF1, FKBPL, SNTG2, KIAA1683, PRIM2, GBP1, PRIM1, ZNF785, ACTBL2, SEPT2, HDAC6, VDAC1, TRAF6, PARK2, MAVS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IRF9_RNF31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IRF9_RNF31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource