	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 17726

FusionGeneSummary for IRF3_GNAS

Fusion gene summary

Fusion gene information	Fusion gene name: IRF3_GNAS
	Fusion gene ID: 17726
		Hgene	Tgene
	Gene symbol	IRF3	GNAS
	Gene ID	3661	2778
	Gene name	interferon regulatory factor 3	GNAS complex locus
	Synonyms	IIAE7	AHO\|C20orf45\|GNAS1\|GPSA\|GSA\|GSP\|NESP\|PITA3\|POH\|SCG6\|SgVI
	Cytomap	19q13.33	20q13.32
	Type of gene	protein-coding	protein-coding
	Description	interferon regulatory factor 3	protein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha
	Modification date	20180527	20180523
	UniProtAcc	Q14653	Q5JWF2
	Ensembl transtripts involved in fusion gene	ENST00000599680, ENST00000309877, ENST00000600911, ENST00000596822, ENST00000601291, ENST00000377139, ENST00000597198, ENST00000593922, ENST00000600022, ENST00000599223, ENST00000596765, ENST00000599144, ENST00000598808, ENST00000377135, ENST00000442265,	ENST00000313949, ENST00000371098, ENST00000371075, ENST00000371100, ENST00000371099, ENST00000371102, ENST00000464624, ENST00000306120, ENST00000371095, ENST00000371085, ENST00000354359, ENST00000265620, ENST00000306090, ENST00000371081,
Fusion gene scores	* DoF score	4 X 4 X 2=32	33 X 25 X 8=6600
	# samples	4	35
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(35/6600*10)=-4.23703919730085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IRF3 [Title/Abstract] AND GNAS [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IRF3	GO:0045944	positive regulation of transcription by RNA polymerase II	9660935

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CN315171	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000599680	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599680	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000309877	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600911	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596822	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000601291	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377139	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000597198	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000593922	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000600022	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599223	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000596765	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000599144	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000598808	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000377135	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000313949	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000371098	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000371075	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000371100	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000371099	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000371102	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000464624	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000306120	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000371095	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000371085	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000354359	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000265620	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000306090	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+
intron-intron	ENST00000442265	ENST00000371081	IRF3	chr19	50164305	-	GNAS	chr20	57478055	+

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FusionProtFeatures for IRF3_GNAS

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IRF3 Q14653	GNAS Q5JWF2
Key transcriptional regulator of type I interferon(IFN)-dependent immune responses which plays a critical role inthe innate immune response against DNA and RNA viruses. Regulatesthe transcription of type I IFN genes (IFN-alpha and IFN-beta) andIFN-stimulated genes (ISG) by binding to an interferon-stimulatedresponse element (ISRE) in their promoters. Acts as a more potentactivator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA)gene and plays a critical role in both the early and late phasesof the IFNA/B gene induction. Found in an inactive form in thecytoplasm of uninfected cells and following viral infection,double-stranded RNA (dsRNA), or toll-like receptor (TLR)signaling, is phosphorylated by IKBKE and TBK1 kinases. Thisinduces a conformational change, leading to its dimerization andnuclear localization and association with CREB binding protein(CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex whichactivates the transcription of the type I IFN and ISG genes. Canactivate distinct gene expression programs in macrophages and caninduce significant apoptosis in primary macrophages.	Guanine nucleotide-binding proteins (G proteins)function as transducers in numerous signaling pathways controlledby G protein-coupled receptors (GPCRs). Signaling involves theactivation of adenylyl cyclases, resulting in increased levels ofthe signaling molecule cAMP. GNAS functions downstream of severalGPCRs, including beta-adrenergic receptors. XLas isoforms interactwith the same set of receptors as GNAS isoforms (By similarity).{ECO:0000250\|UniProtKB:Q6R0H7}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for IRF3_GNAS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IRF3_GNAS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for IRF3_GNAS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for IRF3_GNAS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	IRF3	C4225294	HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 7	1	UNIPROT
Tgene	GNAS	C3494506	Pseudohypoparathyroidism, Type Ia	13	CTD_human;ORPHANET;UNIPROT
Tgene	GNAS	C0242292	McCune-Albright Syndrome	5	ORPHANET;UNIPROT
Tgene	GNAS	C2931404	Albright's hereditary osteodystrophy	4	CTD_human
Tgene	GNAS	C0016065	Polyostotic fibrous dysplasia	3	CTD_human;HPO;ORPHANET
Tgene	GNAS	C0033806	Pseudohypoparathyroidism	3	CTD_human;HPO
Tgene	GNAS	C1857451	Acth-Independent Macronodular Adrenal Hyperplasia	3	ORPHANET;UNIPROT
Tgene	GNAS	C0014130	Endocrine System Diseases	2	CTD_human
Tgene	GNAS	C0034013	Precocious Puberty	2	CTD_human;HPO
Tgene	GNAS	C0221263	Cafe-au-Lait Spots	2	CTD_human
Tgene	GNAS	C0001206	Acromegaly	1	CTD_human;HPO
Tgene	GNAS	C0001624	Adrenal Gland Neoplasms	1	CTD_human
Tgene	GNAS	C0011573	Endogenous depression	1	PSYGENET
Tgene	GNAS	C0019087	Hemorrhagic Disorders	1	CTD_human
Tgene	GNAS	C0020538	Hypertensive disease	1	CTD_human;HPO
Tgene	GNAS	C0021655	Insulin Resistance	1	CTD_human
Tgene	GNAS	C0023897	Liver Diseases, Parasitic	1	CTD_human
Tgene	GNAS	C0027819	Neuroblastoma	1	CTD_human
Tgene	GNAS	C0028754	Obesity	1	CTD_human;HPO
Tgene	GNAS	C0029396	Heterotopic Ossification	1	CTD_human;HPO
Tgene	GNAS	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Tgene	GNAS	C0033835	Pseudopseudohypoparathyroidism	1	CTD_human;ORPHANET
Tgene	GNAS	C0035204	Respiration Disorders	1	CTD_human
Tgene	GNAS	C0036341	Schizophrenia	1	PSYGENET
Tgene	GNAS	C0038587	Substance Withdrawal Syndrome	1	CTD_human
Tgene	GNAS	C0039231	Tachycardia	1	CTD_human
Tgene	GNAS	C0206698	Cholangiocarcinoma	1	CTD_human
Tgene	GNAS	C0221357	Brachydactyly	1	CTD_human;HPO
Tgene	GNAS	C0242184	Hypoxia	1	CTD_human
Tgene	GNAS	C0242216	Biliary calculi	1	CTD_human
Tgene	GNAS	C0334041	Osteoma cutis	1	CTD_human;ORPHANET;UNIPROT
Tgene	GNAS	C0346302	Growth Hormone-Secreting Pituitary Adenoma	1	CTD_human
Tgene	GNAS	C2932715	Pseudohypoparathyroidism Type 1B	1	CTD_human;ORPHANET
Tgene	GNAS	C2932716	Pseudohypoparathyroidism Type 1C	1	ORPHANET;UNIPROT
Tgene	GNAS	C3714756	Intellectual Disability	1	CTD_human;HPO

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Fusion gene ID: 17726

FusionGeneSummary for IRF3_GNAS

FusionProtFeatures for IRF3_GNAS

FusionGeneSequence for IRF3_GNAS

FusionGenePPI for IRF3_GNAS

RelatedDrugs for IRF3_GNAS

RelatedDiseases for IRF3_GNAS