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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17691

FusionGeneSummary for IQGAP2_ACOT12

check button Fusion gene summary
Fusion gene informationFusion gene name: IQGAP2_ACOT12
Fusion gene ID: 17691
HgeneTgene
Gene symbol

IQGAP2

ACOT12

Gene ID

10788

134526

Gene nameIQ motif containing GTPase activating protein 2acyl-CoA thioesterase 12
Synonyms-CACH-1|Cach|STARD15|THEAL
Cytomap

5q13.3

5q14.1

Type of geneprotein-codingprotein-coding
Descriptionras GTPase-activating-like protein IQGAP2acyl-coenzyme A thioesterase 12START domain-containing protein 15StAR-related lipid transfer (START) domain containing 15acyl-CoA thioester hydrolase 12cytoplasmic acetyl-CoA hydrolase 1cytosolic acetyl-CoA hydrolasehCACH-1
Modification date2018052220180523
UniProtAcc

Q13576

Q8WYK0

Ensembl transtripts involved in fusion geneENST00000274364, ENST00000379730, 
ENST00000396234, ENST00000502745, 
ENST00000508410, 
ENST00000307624, 
ENST00000508234, ENST00000513751, 
Fusion gene scores* DoF score4 X 3 X 3=362 X 2 X 2=8
# samples 42
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: IQGAP2 [Title/Abstract] AND ACOT12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIQGAP2

GO:0034314

Arp2/3 complex-mediated actin nucleation

12515716

HgeneIQGAP2

GO:0070493

thrombin-activated receptor signaling pathway

12515716


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A24Z-01AIQGAP2chr5

75866482

+ACOT12chr5

80626759

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000274364ENST00000307624IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
5CDS-5UTRENST00000274364ENST00000508234IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
5CDS-intronENST00000274364ENST00000513751IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
5UTR-3CDSENST00000379730ENST00000307624IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
5UTR-5UTRENST00000379730ENST00000508234IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
5UTR-intronENST00000379730ENST00000513751IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
intron-3CDSENST00000396234ENST00000307624IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
intron-5UTRENST00000396234ENST00000508234IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
intron-intronENST00000396234ENST00000513751IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
intron-3CDSENST00000502745ENST00000307624IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
intron-5UTRENST00000502745ENST00000508234IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
intron-intronENST00000502745ENST00000513751IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
intron-3CDSENST00000508410ENST00000307624IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
intron-5UTRENST00000508410ENST00000508234IQGAP2chr5

75866482

+ACOT12chr5

80626759

-
intron-intronENST00000508410ENST00000513751IQGAP2chr5

75866482

+ACOT12chr5

80626759

-

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FusionProtFeatures for IQGAP2_ACOT12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IQGAP2

Q13576

ACOT12

Q8WYK0

Binds to activated CDC42 and RAC1 but does not seem tostimulate their GTPase activity. Associates with calmodulin. Hydrolyzes acetyl-CoA to acetate and CoA.{ECO:0000269|PubMed:16951743}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IQGAP2_ACOT12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IQGAP2_ACOT12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IQGAP2UBAC1, RELA, RAC1, CDC42, RHOG, CAMKK2, MYC, PEX14, TSHR, MAGEA1, GNAI2, SDF4, DTNBP1, TXNDC12, FOXB1, SUCLA2, CALM1, VCPACOT12ZBTB8A, ACOT11, INPPL1, TLR5, SPAG9, ZMYM6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IQGAP2_ACOT12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IQGAP2_ACOT12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIQGAP2C2239176Liver carcinoma1CTD_human