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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1769

FusionGeneSummary for ANKRD11_FAU

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD11_FAU
Fusion gene ID: 1769
HgeneTgene
Gene symbol

ANKRD11

FAU

Gene ID

29123

2197

Gene nameankyrin repeat domain 11FAU, ubiquitin like and ribosomal protein S30 fusion
SynonymsANCO-1|ANCO1|LZ16|T13FAU1|Fub1|Fubi|MNSFbeta|RPS30|S30|asr1
Cytomap

16q24.3

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 11ankyrin repeat-containing cofactor 1nasopharyngeal carcinoma susceptibility proteintruncated ankyrin repeat domain 11 aberrant transcript 1truncated ankyrin repeat domain 11 aberrant transcript 2ubiquitin-like protein fubi and ribosomal protein S3040S ribosomal protein S30FAU-encoded ubiquitin-like proteinFBR-MuSV-associated ubiquitously expressedFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)monoclo
Modification date2018052320180522
UniProtAcc

Q6UB99

P62861

Ensembl transtripts involved in fusion geneENST00000378330, ENST00000301030, 
ENST00000563291, ENST00000567736, 
ENST00000529639, ENST00000531743, 
ENST00000525297, ENST00000527548, 
ENST00000279259, ENST00000529259, 
ENST00000434372, 
Fusion gene scores* DoF score29 X 15 X 15=65257 X 6 X 2=84
# samples 377
** MAII scorelog2(37/6525*10)=-4.1403807258283
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD11 [Title/Abstract] AND FAU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN275873ANKRD11chr16

89348352

-FAUchr11

64888275

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000378330ENST00000529639ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000378330ENST00000531743ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000378330ENST00000525297ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000378330ENST00000527548ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000378330ENST00000279259ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3UTRENST00000378330ENST00000529259ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-intronENST00000378330ENST00000434372ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000301030ENST00000529639ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000301030ENST00000531743ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000301030ENST00000525297ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000301030ENST00000527548ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000301030ENST00000279259ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3UTRENST00000301030ENST00000529259ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-intronENST00000301030ENST00000434372ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000563291ENST00000529639ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000563291ENST00000531743ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000563291ENST00000525297ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000563291ENST00000527548ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000563291ENST00000279259ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3UTRENST00000563291ENST00000529259ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-intronENST00000563291ENST00000434372ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000567736ENST00000529639ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000567736ENST00000531743ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000567736ENST00000525297ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000567736ENST00000527548ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3CDSENST00000567736ENST00000279259ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-3UTRENST00000567736ENST00000529259ANKRD11chr16

89348352

-FAUchr11

64888275

-
intron-intronENST00000567736ENST00000434372ANKRD11chr16

89348352

-FAUchr11

64888275

-

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FusionProtFeatures for ANKRD11_FAU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD11

Q6UB99

FAU

P62861

Chromatin regulator which modulates histone acetylationand gene expression in neural precursor cells (By similarity). Mayrecruit histone deacetylases (HDACs) to the p160coactivators/nuclear receptor complex to inhibit ligand-dependenttransactivation (PubMed:15184363). Has a role in proliferation anddevelopment of cortical neural precursors (PubMed:25556659). Mayalso regulate bone homeostasis (By similarity).{ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363,ECO:0000269|PubMed:25556659}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKRD11_FAU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKRD11_FAU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKRD11_FAU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKRD11_FAU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANKRD11C0005944Metabolic Bone Disorder1CTD_human
HgeneANKRD11C1510586Autism Spectrum Disorders1CTD_human