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Fusion gene ID: 17644 |
FusionGeneSummary for IPO8_TMTC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IPO8_TMTC1 | Fusion gene ID: 17644 | Hgene | Tgene | Gene symbol | IPO8 | TMTC1 | Gene ID | 10526 | 83857 |
| Gene name | importin 8 | transmembrane and tetratricopeptide repeat containing 1 | |
| Synonyms | RANBP8 | ARG99|OLF|TMTC1A | |
| Cytomap | 12p11.21 | 12p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | importin-8RAN binding protein 8imp8ran-binding protein 8 | transmembrane and TPR repeat-containing protein 1transmembrane and tetratricopeptide repeat containing 1A | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O15397 | Q8IUR5 | |
| Ensembl transtripts involved in fusion gene | ENST00000256079, ENST00000544829, ENST00000538338, | ENST00000256062, ENST00000551659, ENST00000552618, ENST00000319685, ENST00000539277, ENST00000381224, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/8*10)=1.90689059560852 | |
| Context | PubMed: IPO8 [Title/Abstract] AND TMTC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-D5-6533-01A | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000256079 | ENST00000256062 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| Frame-shift | ENST00000256079 | ENST00000551659 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| Frame-shift | ENST00000256079 | ENST00000552618 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| 5CDS-5UTR | ENST00000256079 | ENST00000319685 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| 5CDS-5UTR | ENST00000256079 | ENST00000539277 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| 5CDS-5UTR | ENST00000256079 | ENST00000381224 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-3CDS | ENST00000544829 | ENST00000256062 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-3CDS | ENST00000544829 | ENST00000551659 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-3CDS | ENST00000544829 | ENST00000552618 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-5UTR | ENST00000544829 | ENST00000319685 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-5UTR | ENST00000544829 | ENST00000539277 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-5UTR | ENST00000544829 | ENST00000381224 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-3CDS | ENST00000538338 | ENST00000256062 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-3CDS | ENST00000538338 | ENST00000551659 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-3CDS | ENST00000538338 | ENST00000552618 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-5UTR | ENST00000538338 | ENST00000319685 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-5UTR | ENST00000538338 | ENST00000539277 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
| intron-5UTR | ENST00000538338 | ENST00000381224 | IPO8 | chr12 | 30848498 | - | TMTC1 | chr12 | 29689250 | - |
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FusionProtFeatures for IPO8_TMTC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IPO8 | TMTC1 |
| Seems to function in nuclear protein import, either byacting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1.Acting autonomously, is thought to serve itself as receptor fornuclear localization signals (NLS) and to promote translocation ofimport substrates through the nuclear pore complex (NPC) by anenergy requiring, Ran-dependent mechanism. At the nucleoplasmicside of the NPC, Ran binds to importin, the importin/substratecomplex dissociates and importin is re-exported from the nucleusto the cytoplasm where GTP hydrolysis releases Ran. Thedirectionality of nuclear import is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. In vitro mediates the nuclearimport of SRP19. {ECO:0000269|PubMed:11682607,ECO:0000269|PubMed:9214382}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IPO8_TMTC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IPO8_TMTC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IPO8 | SRP19, RPL23A, KPNB1, AGO3, AGO4, AGO1, AGO2, CUL3, ATXN1, CBX5, YWHAE, EGFR, NXF1, BSG, TNFSF13B, AKR1C2, PNKD, PTGER3, HTR6, KPNA3, RPLP0, TNPO1, IPO9, PPM1G, NTRK1, SSX2IP, SPICE1, CEP128, RPGRIP1L, POC5, LCA5, RPGRIP1, BIN1, CBLB, RAD51D, ZNF7, TRIM28, ZSCAN5A, ZNF629, ACAD8, REPIN1, BCOR, ZNF331, ZBTB10, ZNF696, OSBPL5, ZFP1, ZSCAN25, NANOG, POU5F1, SIGLECL1, GALNT16, HP1BP3, ZNF354C, STOM, CYLD | TMTC1 | ZDHHC17, DPPA4, BCOR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IPO8_TMTC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IPO8_TMTC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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