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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17640

FusionGeneSummary for IPO7_TMEM41B

check button Fusion gene summary
Fusion gene informationFusion gene name: IPO7_TMEM41B
Fusion gene ID: 17640
HgeneTgene
Gene symbol

IPO7

TMEM41B

Gene ID

10527

440026

Gene nameimportin 7transmembrane protein 41B
SynonymsImp7|RANBP7-
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionimportin-7RAN-binding protein 7transmembrane protein 41B
Modification date2018052320180519
UniProtAcc

O95373

Q5BJD5

Ensembl transtripts involved in fusion geneENST00000379719, ENST00000533680, 
ENST00000528080, ENST00000527813, 
ENST00000533723, 
Fusion gene scores* DoF score8 X 5 X 5=2004 X 4 X 3=48
# samples 95
** MAII scorelog2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IPO7 [Title/Abstract] AND TMEM41B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-69-7974-01AIPO7chr11

9406394

+TMEM41Bchr11

9321248

-
TCGARVSKCMTCGA-DA-A95X-06AIPO7chr11

9406394

+TMEM41Bchr11

9321248

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000379719ENST00000528080IPO7chr11

9406394

+TMEM41Bchr11

9321248

-
Frame-shiftENST00000379719ENST00000527813IPO7chr11

9406394

+TMEM41Bchr11

9321248

-
Frame-shiftENST00000379719ENST00000533723IPO7chr11

9406394

+TMEM41Bchr11

9321248

-
intron-3CDSENST00000533680ENST00000528080IPO7chr11

9406394

+TMEM41Bchr11

9321248

-
intron-3CDSENST00000533680ENST00000527813IPO7chr11

9406394

+TMEM41Bchr11

9321248

-
intron-3CDSENST00000533680ENST00000533723IPO7chr11

9406394

+TMEM41Bchr11

9321248

-

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FusionProtFeatures for IPO7_TMEM41B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IPO7

O95373

TMEM41B

Q5BJD5

Functions in nuclear protein import, either by acting asautonomous nuclear transport receptor or as an adapter-likeprotein in association with the importin-beta subunit KPNB1.Acting autonomously, is thought to serve itself as receptor fornuclear localization signals (NLS) and to promote translocation ofimport substrates through the nuclear pore complex (NPC) by anenergy requiring, Ran-dependent mechanism. At the nucleoplasmicside of the NPC, Ran binds to importin, the importin/substratecomplex dissociates and importin is re-exported from the nucleusto the cytoplasm where GTP hydrolysis releases Ran. Thedirectionality of nuclear import is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. Mediates autonomously thenuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Bindsto a beta-like import receptor binding (BIB) domain of RPL23A. Inassociation with KPNB1 mediates the nuclear import of H1 histoneand the Ran-binding site of IPO7 is not required but synergizeswith that of KPNB1 in importin/substrate complex dissociation. Invitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.{ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:9687515}. (Microbial infection) Mediates the nuclear import ofHIV-1 reverse transcription complex (RTC) integrase. Binds andmediates the nuclear import of HIV-1 Rev.{ECO:0000269|PubMed:12853482, ECO:0000269|PubMed:16704975}. Required for normal motor neuron development.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IPO7_TMEM41B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IPO7_TMEM41B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IPO7SRP19, RPL23A, KPNB1, USP49, AIRE, UBC, MYC, RNF146, RAN, SIRT7, FBXO25, CDK2, IGBP1, CA9, METTL18, CFTR, SOX2, EGFR, FBXO6, APEH, CAND1, ELAC2, HARS, HSPA1L, HSPA4L, KARS, NFRKB, PFDN5, RNASEH2A, TNPO1, TRMT112, STAU1, MDM2, CCDC8, RNF2, ILK, RIC3, NUSAP1, VTI1B, COMTD1, CD274, TNFSF13B, ZBTB38, VSIG2, PNKD, RP2, EDA, PTGER3, RPS6KB2, UNK, HSP90AB1, HSPA8, HSPB1, IPO5, IPO9, SLC25A3, MPHOSPH10, PPM1G, NTRK1, IFI16, CEP162, LCA5, RPGRIP1L, SSX2IP, SPICE1, DCTN1, CEP19, RPGRIP1, CAPZA2, MAD2L1, NUP153, HDAC6, LIMA1, NUP107, VPS16, ASPM, MCM2, CDC5L, DUSP5, SIGLECL1, HP1BP3, AURKAIP1, FZD10, TMEM206, HTR2C, UXS1, CHRM3, PTPRE, TRIM25, G3BP1, BRCA1, TESTMEM41BELAVL1, BMI1, DPYS, APOB, TCTN3, PPP2CB, TTC30B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IPO7_TMEM41B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IPO7_TMEM41B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIPO7C0019693HIV Infections1CTD_human