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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17633

FusionGeneSummary for IPO5_IPO5

check button Fusion gene summary
Fusion gene informationFusion gene name: IPO5_IPO5
Fusion gene ID: 17633
HgeneTgene
Gene symbol

IPO5

IPO5

Gene ID

3843

3843

Gene nameimportin 5importin 5
SynonymsIMB3|KPNB3|Pse1|RANBP5|imp5IMB3|KPNB3|Pse1|RANBP5|imp5
Cytomap

13q32.2

13q32.2

Type of geneprotein-codingprotein-coding
Descriptionimportin-5RAN binding protein 5Ran_GTP binding protein 5importin beta-3 subunitimportin subunit beta-3karyopherin (importin) beta 3karyopherin beta-3ran-binding protein 5importin-5RAN binding protein 5Ran_GTP binding protein 5importin beta-3 subunitimportin subunit beta-3karyopherin (importin) beta 3karyopherin beta-3ran-binding protein 5
Modification date2018052320180523
UniProtAcc

O00410

O00410

Ensembl transtripts involved in fusion geneENST00000261574, ENST00000490680, 
ENST00000539640, ENST00000493492, 
ENST00000261574, ENST00000490680, 
ENST00000539640, ENST00000493492, 
Fusion gene scores* DoF score1 X 4 X 1=45 X 8 X 3=120
# samples 510
** MAII scorelog2(5/4*10)=3.64385618977473log2(10/120*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IPO5 [Title/Abstract] AND IPO5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIPO5

GO:0006610

ribosomal protein import into nucleus

9687515

TgeneIPO5

GO:0006610

ribosomal protein import into nucleus

9687515


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA249390IPO5chr13

98658596

+IPO5chr13

98658460

+
ChiTaRS3.1BF435791IPO5chr13

98628910

-IPO5chr13

98666336

-
ChiTaRS3.1CN352531IPO5chr13

98662153

-IPO5chr13

98655171

+
ChiTaRS3.1AW606649IPO5chr13

98670890

-IPO5chr13

98669075

+
ChiTaRS3.1BE856566IPO5chr13

98628910

-IPO5chr13

98666336

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261574ENST00000261574IPO5chr13

98658596

+IPO5chr13

98658460

+
In-frameENST00000261574ENST00000490680IPO5chr13

98658596

+IPO5chr13

98658460

+
In-frameENST00000261574ENST00000539640IPO5chr13

98658596

+IPO5chr13

98658460

+
5CDS-3UTRENST00000261574ENST00000493492IPO5chr13

98658596

+IPO5chr13

98658460

+
In-frameENST00000490680ENST00000261574IPO5chr13

98658596

+IPO5chr13

98658460

+
In-frameENST00000490680ENST00000490680IPO5chr13

98658596

+IPO5chr13

98658460

+
In-frameENST00000490680ENST00000539640IPO5chr13

98658596

+IPO5chr13

98658460

+
5CDS-3UTRENST00000490680ENST00000493492IPO5chr13

98658596

+IPO5chr13

98658460

+
In-frameENST00000539640ENST00000261574IPO5chr13

98658596

+IPO5chr13

98658460

+
In-frameENST00000539640ENST00000490680IPO5chr13

98658596

+IPO5chr13

98658460

+
In-frameENST00000539640ENST00000539640IPO5chr13

98658596

+IPO5chr13

98658460

+
5CDS-3UTRENST00000539640ENST00000493492IPO5chr13

98658596

+IPO5chr13

98658460

+
3UTR-3CDSENST00000493492ENST00000261574IPO5chr13

98658596

+IPO5chr13

98658460

+
3UTR-3CDSENST00000493492ENST00000490680IPO5chr13

98658596

+IPO5chr13

98658460

+
3UTR-3CDSENST00000493492ENST00000539640IPO5chr13

98658596

+IPO5chr13

98658460

+
3UTR-3UTRENST00000493492ENST00000493492IPO5chr13

98658596

+IPO5chr13

98658460

+
intron-3CDSENST00000261574ENST00000261574IPO5chr13

98628910

-IPO5chr13

98666336

-
intron-3CDSENST00000261574ENST00000490680IPO5chr13

98628910

-IPO5chr13

98666336

-
intron-3CDSENST00000261574ENST00000539640IPO5chr13

98628910

-IPO5chr13

98666336

-
intron-intronENST00000261574ENST00000493492IPO5chr13

98628910

-IPO5chr13

98666336

-
5UTR-3CDSENST00000490680ENST00000261574IPO5chr13

98628910

-IPO5chr13

98666336

-
5UTR-3CDSENST00000490680ENST00000490680IPO5chr13

98628910

-IPO5chr13

98666336

-
5UTR-3CDSENST00000490680ENST00000539640IPO5chr13

98628910

-IPO5chr13

98666336

-
5UTR-intronENST00000490680ENST00000493492IPO5chr13

98628910

-IPO5chr13

98666336

-
intron-3CDSENST00000539640ENST00000261574IPO5chr13

98628910

-IPO5chr13

98666336

-
intron-3CDSENST00000539640ENST00000490680IPO5chr13

98628910

-IPO5chr13

98666336

-
intron-3CDSENST00000539640ENST00000539640IPO5chr13

98628910

-IPO5chr13

98666336

-
intron-intronENST00000539640ENST00000493492IPO5chr13

98628910

-IPO5chr13

98666336

-
intron-3CDSENST00000493492ENST00000261574IPO5chr13

98628910

-IPO5chr13

98666336

-
intron-3CDSENST00000493492ENST00000490680IPO5chr13

98628910

-IPO5chr13

98666336

-
intron-3CDSENST00000493492ENST00000539640IPO5chr13

98628910

-IPO5chr13

98666336

-
intron-intronENST00000493492ENST00000493492IPO5chr13

98628910

-IPO5chr13

98666336

-
Frame-shiftENST00000261574ENST00000261574IPO5chr13

98662153

-IPO5chr13

98655171

+
Frame-shiftENST00000261574ENST00000490680IPO5chr13

98662153

-IPO5chr13

98655171

+
Frame-shiftENST00000261574ENST00000539640IPO5chr13

98662153

-IPO5chr13

98655171

+
5CDS-intronENST00000261574ENST00000493492IPO5chr13

98662153

-IPO5chr13

98655171

+
Frame-shiftENST00000490680ENST00000261574IPO5chr13

98662153

-IPO5chr13

98655171

+
Frame-shiftENST00000490680ENST00000490680IPO5chr13

98662153

-IPO5chr13

98655171

+
Frame-shiftENST00000490680ENST00000539640IPO5chr13

98662153

-IPO5chr13

98655171

+
5CDS-intronENST00000490680ENST00000493492IPO5chr13

98662153

-IPO5chr13

98655171

+
Frame-shiftENST00000539640ENST00000261574IPO5chr13

98662153

-IPO5chr13

98655171

+
Frame-shiftENST00000539640ENST00000490680IPO5chr13

98662153

-IPO5chr13

98655171

+
Frame-shiftENST00000539640ENST00000539640IPO5chr13

98662153

-IPO5chr13

98655171

+
5CDS-intronENST00000539640ENST00000493492IPO5chr13

98662153

-IPO5chr13

98655171

+
intron-3CDSENST00000493492ENST00000261574IPO5chr13

98662153

-IPO5chr13

98655171

+
intron-3CDSENST00000493492ENST00000490680IPO5chr13

98662153

-IPO5chr13

98655171

+
intron-3CDSENST00000493492ENST00000539640IPO5chr13

98662153

-IPO5chr13

98655171

+
intron-intronENST00000493492ENST00000493492IPO5chr13

98662153

-IPO5chr13

98655171

+
Frame-shiftENST00000261574ENST00000261574IPO5chr13

98670890

-IPO5chr13

98669075

+
Frame-shiftENST00000261574ENST00000490680IPO5chr13

98670890

-IPO5chr13

98669075

+
Frame-shiftENST00000261574ENST00000539640IPO5chr13

98670890

-IPO5chr13

98669075

+
5CDS-intronENST00000261574ENST00000493492IPO5chr13

98670890

-IPO5chr13

98669075

+
Frame-shiftENST00000490680ENST00000261574IPO5chr13

98670890

-IPO5chr13

98669075

+
Frame-shiftENST00000490680ENST00000490680IPO5chr13

98670890

-IPO5chr13

98669075

+
Frame-shiftENST00000490680ENST00000539640IPO5chr13

98670890

-IPO5chr13

98669075

+
5CDS-intronENST00000490680ENST00000493492IPO5chr13

98670890

-IPO5chr13

98669075

+
Frame-shiftENST00000539640ENST00000261574IPO5chr13

98670890

-IPO5chr13

98669075

+
Frame-shiftENST00000539640ENST00000490680IPO5chr13

98670890

-IPO5chr13

98669075

+
Frame-shiftENST00000539640ENST00000539640IPO5chr13

98670890

-IPO5chr13

98669075

+
5CDS-intronENST00000539640ENST00000493492IPO5chr13

98670890

-IPO5chr13

98669075

+
intron-3CDSENST00000493492ENST00000261574IPO5chr13

98670890

-IPO5chr13

98669075

+
intron-3CDSENST00000493492ENST00000490680IPO5chr13

98670890

-IPO5chr13

98669075

+
intron-3CDSENST00000493492ENST00000539640IPO5chr13

98670890

-IPO5chr13

98669075

+
intron-intronENST00000493492ENST00000493492IPO5chr13

98670890

-IPO5chr13

98669075

+

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FusionProtFeatures for IPO5_IPO5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IPO5

O00410

IPO5

O00410

Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of ribosomalproteins RPL23A, RPS7 and RPL5. Binds to a beta-like importreceptor binding (BIB) domain of RPL23A. In vitro, mediatesnuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 andmediates its nuclear import following neuronal stimulation (Bysimilarity). In case of HIV-1 infection, binds and mediates thenuclear import of HIV-1 Rev. {ECO:0000250|UniProtKB:Q8BKC5,ECO:0000269|PubMed:9687515}. Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of ribosomalproteins RPL23A, RPS7 and RPL5. Binds to a beta-like importreceptor binding (BIB) domain of RPL23A. In vitro, mediatesnuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 andmediates its nuclear import following neuronal stimulation (Bysimilarity). In case of HIV-1 infection, binds and mediates thenuclear import of HIV-1 Rev. {ECO:0000250|UniProtKB:Q8BKC5,ECO:0000269|PubMed:9687515}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IPO5_IPO5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IPO5_IPO5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IPO5_IPO5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IPO5_IPO5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIPO5C0036341Schizophrenia4PSYGENET
TgeneIPO5C0036341Schizophrenia4PSYGENET