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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17619

FusionGeneSummary for IP6K1_TRAIP

check button Fusion gene summary
Fusion gene informationFusion gene name: IP6K1_TRAIP
Fusion gene ID: 17619
HgeneTgene
Gene symbol

IP6K1

TRAIP

Gene ID

9807

10293

Gene nameinositol hexakisphosphate kinase 1TRAF interacting protein
SynonymsIHPK1|PiUSRNF206|SCKL9|TRIP
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptioninositol hexakisphosphate kinase 1ATP:1D-myo-inositol-hexakisphosphate phosphotransferasePi uptake stimulatorinositol hexaphosphate kinase 1insP6 kinase 1E3 ubiquitin-protein ligase TRAIPRING-type E3 ubiquitin transferase TRAIPring finger protein 206
Modification date2018051920180519
UniProtAcc

Q92551

Q9BWF2

Ensembl transtripts involved in fusion geneENST00000321599, ENST00000395238, 
ENST00000468463, ENST00000460540, 
ENST00000498149, 		ENST00000331456, 
ENST00000469027, ENST00000473863, 
Fusion gene scores* DoF score5 X 3 X 7=1054 X 4 X 5=80
# samples 85
** MAII scorelog2(8/105*10)=-0.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IP6K1 [Title/Abstract] AND TRAIP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIP6K1

GO:0046854

phosphatidylinositol phosphorylation

10574768

TgeneTRAIP

GO:0010804

negative regulation of tumor necrosis factor-mediated signaling pathway

19151749


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CR-6488-01AIP6K1chr3

49823787

-TRAIPchr3

49877806

-
TCGARVSTADTCGA-BR-8678-01AIP6K1chr3

49823787

-TRAIPchr3

49885633

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000321599ENST00000331456IP6K1chr3

49823787

-TRAIPchr3

49877806

-
5UTR-3CDSENST00000321599ENST00000469027IP6K1chr3

49823787

-TRAIPchr3

49877806

-
5UTR-intronENST00000321599ENST00000473863IP6K1chr3

49823787

-TRAIPchr3

49877806

-
5UTR-3CDSENST00000395238ENST00000331456IP6K1chr3

49823787

-TRAIPchr3

49877806

-
5UTR-3CDSENST00000395238ENST00000469027IP6K1chr3

49823787

-TRAIPchr3

49877806

-
5UTR-intronENST00000395238ENST00000473863IP6K1chr3

49823787

-TRAIPchr3

49877806

-
5UTR-3CDSENST00000468463ENST00000331456IP6K1chr3

49823787

-TRAIPchr3

49877806

-
5UTR-3CDSENST00000468463ENST00000469027IP6K1chr3

49823787

-TRAIPchr3

49877806

-
5UTR-intronENST00000468463ENST00000473863IP6K1chr3

49823787

-TRAIPchr3

49877806

-
intron-3CDSENST00000460540ENST00000331456IP6K1chr3

49823787

-TRAIPchr3

49877806

-
intron-3CDSENST00000460540ENST00000469027IP6K1chr3

49823787

-TRAIPchr3

49877806

-
intron-intronENST00000460540ENST00000473863IP6K1chr3

49823787

-TRAIPchr3

49877806

-
intron-3CDSENST00000498149ENST00000331456IP6K1chr3

49823787

-TRAIPchr3

49877806

-
intron-3CDSENST00000498149ENST00000469027IP6K1chr3

49823787

-TRAIPchr3

49877806

-
intron-intronENST00000498149ENST00000473863IP6K1chr3

49823787

-TRAIPchr3

49877806

-
5UTR-3CDSENST00000321599ENST00000331456IP6K1chr3

49823787

-TRAIPchr3

49885633

-
5UTR-3CDSENST00000321599ENST00000469027IP6K1chr3

49823787

-TRAIPchr3

49885633

-
5UTR-5UTRENST00000321599ENST00000473863IP6K1chr3

49823787

-TRAIPchr3

49885633

-
5UTR-3CDSENST00000395238ENST00000331456IP6K1chr3

49823787

-TRAIPchr3

49885633

-
5UTR-3CDSENST00000395238ENST00000469027IP6K1chr3

49823787

-TRAIPchr3

49885633

-
5UTR-5UTRENST00000395238ENST00000473863IP6K1chr3

49823787

-TRAIPchr3

49885633

-
5UTR-3CDSENST00000468463ENST00000331456IP6K1chr3

49823787

-TRAIPchr3

49885633

-
5UTR-3CDSENST00000468463ENST00000469027IP6K1chr3

49823787

-TRAIPchr3

49885633

-
5UTR-5UTRENST00000468463ENST00000473863IP6K1chr3

49823787

-TRAIPchr3

49885633

-
intron-3CDSENST00000460540ENST00000331456IP6K1chr3

49823787

-TRAIPchr3

49885633

-
intron-3CDSENST00000460540ENST00000469027IP6K1chr3

49823787

-TRAIPchr3

49885633

-
intron-5UTRENST00000460540ENST00000473863IP6K1chr3

49823787

-TRAIPchr3

49885633

-
intron-3CDSENST00000498149ENST00000331456IP6K1chr3

49823787

-TRAIPchr3

49885633

-
intron-3CDSENST00000498149ENST00000469027IP6K1chr3

49823787

-TRAIPchr3

49885633

-
intron-5UTRENST00000498149ENST00000473863IP6K1chr3

49823787

-TRAIPchr3

49885633

-

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FusionProtFeatures for IP6K1_TRAIP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IP6K1

Q92551

TRAIP

Q9BWF2

Converts inositol hexakisphosphate (InsP6) todiphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. E3 ubiquitin ligase acting as a negative regulator ofinnate immune signaling. Inhibits activation of NF-kappa-Bmediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediatedIRF3 activation and subsequent IFNB1 production and cellularantiviral response by promoting 'Lys-48'-linked polyubiquitinationof TNK1 leading to its proteasomal degradation (By similarity)(PubMed:22945920). Involved in response to genotoxic lesionsduring genome replication. Promotes H2AX and RPA2 phosphorylationafter replication-associated DNA damage and assists forkprogression at UV-induced replication-blocking lesions during Sphase (PubMed:26595769). Has also been proposed to play a role inpromoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLNin order to facilitate bypass of DNA lesions and preserve genomicintegrity (PubMed:24553286). The function in translesion synthesisis controversial (PubMed:26595769). {ECO:0000250|UniProtKB:Q8VIG6,ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:24553286,ECO:0000269|PubMed:26595769, ECO:0000303|PubMed:26595769}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IP6K1_TRAIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IP6K1_TRAIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IP6K1EXOSC7, RAB3IL1, CACNA1A, DDB1, CUL4A, RBX1, GPS1, COPS2, UBXN4, CLK1, VSIG1, FGFR2, TFCP2, DEFA5, DEFA6, CLMP, GYPB, TRIM25TRAIPFLII, TRAF1, TRAF2, TNFRSF1B, TNFRSF8, UBE2U, TSG101, UBE2H, UBE2K, UBE2Z, CYLD, TRAIP, TRAF3, TRAF5, TRAF6, RAD21, TBK1, SYK, UBE2D1, UBE2D2, UBE2D3, APP, USP2, RNF4, TRIM23, RNF114, TRIM41, UBOX5, POLH, POLK, MAPRE2, PCNA, MAGEF1, MAP3K7, UIMC1, RNF20, RNF40


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IP6K1_TRAIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IP6K1_TRAIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTRAIPC0013336Dwarfism1CTD_human
TgeneTRAIPC0025958Microcephaly1CTD_human
TgeneTRAIPC4225212SECKEL SYNDROME 91UNIPROT