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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17604

FusionGeneSummary for INTS7_DTL

check button Fusion gene summary
Fusion gene informationFusion gene name: INTS7_DTL
Fusion gene ID: 17604
HgeneTgene
Gene symbol

INTS7

DTL

Gene ID

25896

51514

Gene nameintegrator complex subunit 7denticleless E3 ubiquitin protein ligase homolog
SynonymsC1orf73|INT7CDT2|DCAF2|L2DTL|RAMP
Cytomap

1q32.3

1q32.3

Type of geneprotein-codingprotein-coding
Descriptionintegrator complex subunit 7denticleless protein homologDDB1- and CUL4-associated factor 2RA-regulated nuclear matrix-associated proteinlethal(2) denticleless protein homologretinoic acid-regulated nuclear matrix-associated protein
Modification date2018052320180519
UniProtAcc

Q9NVH2

Q9NZJ0

Ensembl transtripts involved in fusion geneENST00000469606, ENST00000366994, 
ENST00000366993, ENST00000366992, 
ENST00000440600, 
ENST00000366991, 
ENST00000542077, ENST00000475419, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: INTS7 [Title/Abstract] AND DTL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneINTS7

GO:0016180

snRNA processing

16239144

HgeneINTS7

GO:0071479

cellular response to ionizing radiation

21659603

TgeneDTL

GO:0000209

protein polyubiquitination

18794347

TgeneDTL

GO:0006511

ubiquitin-dependent protein catabolic process

18794347

TgeneDTL

GO:0006513

protein monoubiquitination

20129063

TgeneDTL

GO:0006974

cellular response to DNA damage stimulus

20129063

TgeneDTL

GO:0009411

response to UV

18794347

TgeneDTL

GO:0019985

translesion synthesis

20129063


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-CH-5752-01AINTS7chr1

212208686

-DTLchr1

212236226

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000469606ENST00000366991INTS7chr1

212208686

-DTLchr1

212236226

+
5UTR-3CDSENST00000469606ENST00000542077INTS7chr1

212208686

-DTLchr1

212236226

+
5UTR-3UTRENST00000469606ENST00000475419INTS7chr1

212208686

-DTLchr1

212236226

+
Frame-shiftENST00000366994ENST00000366991INTS7chr1

212208686

-DTLchr1

212236226

+
Frame-shiftENST00000366994ENST00000542077INTS7chr1

212208686

-DTLchr1

212236226

+
5CDS-3UTRENST00000366994ENST00000475419INTS7chr1

212208686

-DTLchr1

212236226

+
Frame-shiftENST00000366993ENST00000366991INTS7chr1

212208686

-DTLchr1

212236226

+
Frame-shiftENST00000366993ENST00000542077INTS7chr1

212208686

-DTLchr1

212236226

+
5CDS-3UTRENST00000366993ENST00000475419INTS7chr1

212208686

-DTLchr1

212236226

+
Frame-shiftENST00000366992ENST00000366991INTS7chr1

212208686

-DTLchr1

212236226

+
Frame-shiftENST00000366992ENST00000542077INTS7chr1

212208686

-DTLchr1

212236226

+
5CDS-3UTRENST00000366992ENST00000475419INTS7chr1

212208686

-DTLchr1

212236226

+
Frame-shiftENST00000440600ENST00000366991INTS7chr1

212208686

-DTLchr1

212236226

+
Frame-shiftENST00000440600ENST00000542077INTS7chr1

212208686

-DTLchr1

212236226

+
5CDS-3UTRENST00000440600ENST00000475419INTS7chr1

212208686

-DTLchr1

212236226

+

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FusionProtFeatures for INTS7_DTL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INTS7

Q9NVH2

DTL

Q9NZJ0

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3ubiquitin-protein ligase complex required for cell cycle control,DNA damage response and translesion DNA synthesis. The DCX(DTL)complex, also named CRL4(CDT2) complex, mediates thepolyubiquitination and subsequent degradation of CDT1,CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906,PubMed:16949367, PubMed:16964240, PubMed:17085480,PubMed:18703516, PubMed:18794347, PubMed:18794348,PubMed:19332548, PubMed:20129063, PubMed:23478441,PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1degradation in response to DNA damage is necessary to ensureproper cell cycle regulation of DNA replication (PubMed:16861906,PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradationduring S phase or following UV irradiation is essential to controlreplication licensing (PubMed:18794348, PubMed:19332548). KMT5Adegradation is also important for a proper regulation ofmechanisms such as TGF-beta signaling, cell cycle progression, DNArepair and cell migration (PubMed:23478445). Most substratesrequire their interaction with PCNA for their polyubiquitination:substrates interact with PCNA via their PIP-box, and thosecontaining the 'K+4' motif in the PIP box, recruit the DCX(DTL)complex, leading to their degradation. In undamaged proliferatingcells, the DCX(DTL) complex also promotes the 'Lys-164'monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063,PubMed:23478441, PubMed:23478445, PubMed:23677613).{ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367,ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480,ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347,ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548,ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441,ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613,ECO:0000269|PubMed:27906959}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for INTS7_DTL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INTS7_DTL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INTS7RPAP2, INTS1, INTS3, INTS5, INTS6, SHFM1, INTS10, CTDP1, INTS2, INTS8, PAXIP1, SOX2, DCP2, SSBP1, HLA-DPA1, SPACA1, NRG1, SLAMF1, DLK1, TMEFF1, PRKCSH, VSIG4, FNDC4, FAF2, C7orf26, CPSF3L, ASUN, FGD1, HNRNPD, PML, RALA, BUB3, VPS26A, CKAP5, SYNCRIP, KIF1C, GOLT1B, ANLN, ACTR5, SCN3B, VSIG1, CD79B, PDCD1, TOR1AIP2, CLEC14A, PMEL, NTRK3, MGRN1, TNFRSF17, IL13RA2, TRIM25DTLCDKN1A, COPS6, DDB1, CUL4B, CUL4A, WDR5, SETD8, KAT2A, PCNA, MSH6, MSH2, TP53, MDM2, COPS5, AURKB, TOB1, ATR, TUBG1, DDA1, COPS3, COPS4, CHEK1, CFTR, SHPRH, HLTF, RAD18, FBXO11, LYN, CDT1, FBXO18, TDG, YWHAE, YWHAQ, YWHAZ, YWHAB, YWHAG, YWHAH, SFN, UBE2D1, UBE2N, TCEAL1, C9orf41, ERCC5, UBE2I, COPS7A, WHSC1, RBX1, UBE2E2, UBE2E3, UBE2E1, POLD4, CCT3, PFDN2, CCT7, SSSCA1, COPS8, GLMN, PDDC1, CAMK2D, DEF8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INTS7_DTL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for INTS7_DTL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDTLC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneDTLC0036095Salivary Gland Neoplasms1CTD_human