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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17602

FusionGeneSummary for INTS6_DCBLD2

check button Fusion gene summary
Fusion gene informationFusion gene name: INTS6_DCBLD2
Fusion gene ID: 17602
HgeneTgene
Gene symbol

INTS6

DCBLD2

Gene ID

26512

131566

Gene nameintegrator complex subunit 6discoidin, CUB and LCCL domain containing 2
SynonymsDBI-1|DDX26|DDX26A|DICE1|HDB|INT6|Notchl2CLCP1|ESDN
Cytomap

13q14.3

3q12.1|3

Type of geneprotein-codingprotein-coding
Descriptionintegrator complex subunit 6DEAD box proteinDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26RNA helicase HDBprotein deleted in cancer 1discoidin, CUB and LCCL domain-containing protein 21700055P21RikCUB, LCCL and coagulation factor V/VIII-homology domains protein 1coagulation factor V/VIII-homology domains protein 1endothelial and smooth muscle cell-derived neuropilin-like protein
Modification date2018052320180519
UniProtAcc

Q9UL03

Q96PD2

Ensembl transtripts involved in fusion geneENST00000311234, ENST00000398119, 
ENST00000497989, ENST00000425000, 
ENST00000490542, ENST00000463928, 
ENST00000420668, ENST00000491723, 
ENST00000442263, 
ENST00000326840, 
ENST00000326857, ENST00000469648, 
Fusion gene scores* DoF score4 X 2 X 4=322 X 2 X 2=8
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: INTS6 [Title/Abstract] AND DCBLD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneINTS6

GO:0016180

snRNA processing

16239144

TgeneDCBLD2

GO:0030308

negative regulation of cell growth

11447234

TgeneDCBLD2

GO:0042060

wound healing

11447234


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-23-1114-01BINTS6chr13

52025161

-DCBLD2chr3

98600611

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000311234ENST00000326840INTS6chr13

52025161

-DCBLD2chr3

98600611

-
Frame-shiftENST00000311234ENST00000326857INTS6chr13

52025161

-DCBLD2chr3

98600611

-
5CDS-intronENST00000311234ENST00000469648INTS6chr13

52025161

-DCBLD2chr3

98600611

-
Frame-shiftENST00000398119ENST00000326840INTS6chr13

52025161

-DCBLD2chr3

98600611

-
Frame-shiftENST00000398119ENST00000326857INTS6chr13

52025161

-DCBLD2chr3

98600611

-
5CDS-intronENST00000398119ENST00000469648INTS6chr13

52025161

-DCBLD2chr3

98600611

-
intron-3CDSENST00000497989ENST00000326840INTS6chr13

52025161

-DCBLD2chr3

98600611

-
intron-3CDSENST00000497989ENST00000326857INTS6chr13

52025161

-DCBLD2chr3

98600611

-
intron-intronENST00000497989ENST00000469648INTS6chr13

52025161

-DCBLD2chr3

98600611

-
5UTR-3CDSENST00000425000ENST00000326840INTS6chr13

52025161

-DCBLD2chr3

98600611

-
5UTR-3CDSENST00000425000ENST00000326857INTS6chr13

52025161

-DCBLD2chr3

98600611

-
5UTR-intronENST00000425000ENST00000469648INTS6chr13

52025161

-DCBLD2chr3

98600611

-
intron-3CDSENST00000490542ENST00000326840INTS6chr13

52025161

-DCBLD2chr3

98600611

-
intron-3CDSENST00000490542ENST00000326857INTS6chr13

52025161

-DCBLD2chr3

98600611

-
intron-intronENST00000490542ENST00000469648INTS6chr13

52025161

-DCBLD2chr3

98600611

-
Frame-shiftENST00000463928ENST00000326840INTS6chr13

52025161

-DCBLD2chr3

98600611

-
Frame-shiftENST00000463928ENST00000326857INTS6chr13

52025161

-DCBLD2chr3

98600611

-
5CDS-intronENST00000463928ENST00000469648INTS6chr13

52025161

-DCBLD2chr3

98600611

-
Frame-shiftENST00000420668ENST00000326840INTS6chr13

52025161

-DCBLD2chr3

98600611

-
Frame-shiftENST00000420668ENST00000326857INTS6chr13

52025161

-DCBLD2chr3

98600611

-
5CDS-intronENST00000420668ENST00000469648INTS6chr13

52025161

-DCBLD2chr3

98600611

-
5UTR-3CDSENST00000491723ENST00000326840INTS6chr13

52025161

-DCBLD2chr3

98600611

-
5UTR-3CDSENST00000491723ENST00000326857INTS6chr13

52025161

-DCBLD2chr3

98600611

-
5UTR-intronENST00000491723ENST00000469648INTS6chr13

52025161

-DCBLD2chr3

98600611

-
intron-3CDSENST00000442263ENST00000326840INTS6chr13

52025161

-DCBLD2chr3

98600611

-
intron-3CDSENST00000442263ENST00000326857INTS6chr13

52025161

-DCBLD2chr3

98600611

-
intron-intronENST00000442263ENST00000469648INTS6chr13

52025161

-DCBLD2chr3

98600611

-

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FusionProtFeatures for INTS6_DCBLD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INTS6

Q9UL03

DCBLD2

Q96PD2

Component of the Integrator (INT) complex, a complexinvolved in the small nuclear RNAs (snRNA) U1 and U2 transcriptionand in their 3'-box-dependent processing. The Integrator complexis associated with the C-terminal domain (CTD) of RNA polymeraseII largest subunit (POLR2A) and is recruited to the U1 and U2snRNAs genes (Probable). Mediates recruitment of cytoplasmicdynein to the nuclear envelope, probably as component of the INTcomplex (PubMed:23904267). May have a tumor suppressor role; anectopic expression suppressing tumor cell growth (PubMed:15254679,PubMed:16239144). {ECO:0000269|PubMed:15254679,ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267,ECO:0000305|PubMed:16239144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for INTS6_DCBLD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INTS6_DCBLD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INTS6INTS1, INTS3, INTS5, INTS2, INTS4, DDX26B, INTS7, INTS8, INTS9, INTS10, CPSF3L, INTS12, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2G, POLR2H, POLR2J, POLR2L, PPP2R1A, PPP2R1B, PPP1CB, PPP2CA, PPP2CB, ASUN, VWA9, C7orf26, NAIF1, NABP2, ZMYND8, ZNF592, ZNF687, SHFM1, CTDP1, MCM7, RPA3, RPA2, RPA1, SHMT2, MOV10, NXF1, BMI1, CTDSP2, SCARA3, OLFM4, NTRK1, DDX24, NABP1, CDC5L, PROZ, LRP1, TBL1Y, BBS7, TRIM25DCBLD2SEMA4B, ELAVL1, EGFR, TRAF6, HLA-DRA, ITM2B, PTPRK, SIAE, NAAA, PCDHB11, TCTN2, TMPRSS11B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INTS6_DCBLD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for INTS6_DCBLD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDCBLD2C0032460Polycystic Ovary Syndrome1CTD_human
TgeneDCBLD2C0038356Stomach Neoplasms1CTD_human