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Fusion gene ID: 17595 |
FusionGeneSummary for INTS4_TXLNG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: INTS4_TXLNG | Fusion gene ID: 17595 | Hgene | Tgene | Gene symbol | INTS4 | TXLNG | Gene ID | 92105 | 55787 |
| Gene name | integrator complex subunit 4 | taxilin gamma | |
| Synonyms | INT4|MST093 | CXorf15|ELRG|FIAT|LSR5|TXLNGX | |
| Cytomap | 11q14.1 | Xp22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | integrator complex subunit 4MSTP093 | gamma-taxilinenvironmental LPS-respondingenvironmental lipopolysaccharide-responding gene proteinfactor inhibiting ATF4-mediated transcriptionfactor inhibiting activating transcription factor 4 (ATF4)-mediated transcriptionlipopolysaccharide specific | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96HW7 | Q9NUQ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000534064, ENST00000535943, ENST00000525931, ENST00000529807, ENST00000527522, | ENST00000380122, ENST00000398155, ENST00000485153, | |
| Fusion gene scores | * DoF score | 17 X 9 X 9=1377 | 3 X 6 X 6=108 |
| # samples | 18 | 8 | |
| ** MAII score | log2(18/1377*10)=-2.93545974780529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/108*10)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: INTS4 [Title/Abstract] AND TXLNG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | INTS4 | GO:0016180 | snRNA processing | 16239144 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU732522 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000534064 | ENST00000380122 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000534064 | ENST00000398155 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000534064 | ENST00000485153 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000535943 | ENST00000380122 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000535943 | ENST00000398155 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000535943 | ENST00000485153 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000525931 | ENST00000380122 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000525931 | ENST00000398155 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000525931 | ENST00000485153 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000529807 | ENST00000380122 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000529807 | ENST00000398155 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000529807 | ENST00000485153 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000527522 | ENST00000380122 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000527522 | ENST00000398155 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
| intron-intron | ENST00000527522 | ENST00000485153 | INTS4 | chr11 | 77690489 | + | TXLNG | chrX | 16854126 | - |
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FusionProtFeatures for INTS4_TXLNG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| INTS4 | TXLNG |
| Component of the Integrator (INT) complex, a complexinvolved in the small nuclear RNAs (snRNA) U1 and U2 transcriptionand in their 3'-box-dependent processing. The Integrator complexis associated with the C-terminal domain (CTD) of RNA polymeraseII largest subunit (POLR2A) and is recruited to the U1 and U2snRNAs genes (Probable). Mediates recruitment of cytoplasmicdynein to the nuclear envelope, probably as component of the INTcomplex (PubMed:23904267). {ECO:0000269|PubMed:23904267,ECO:0000305|PubMed:16239144}. | May be involved in intracellular vesicle traffic.Inhibits ATF4-mediated transcription, possibly by dimerizing withATF4 to form inactive dimers that cannot bind DNA. May be involvedin regulating bone mass density through an ATF4-dependent pathway.May be involved in cell cycle progression.{ECO:0000269|PubMed:15911876, ECO:0000269|PubMed:18068885}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for INTS4_TXLNG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for INTS4_TXLNG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for INTS4_TXLNG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for INTS4_TXLNG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | INTS4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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