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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17587

FusionGeneSummary for INTS4_PGR

check button Fusion gene summary
Fusion gene informationFusion gene name: INTS4_PGR
Fusion gene ID: 17587
HgeneTgene
Gene symbol

INTS4

PGR

Gene ID

92105

5241

Gene nameintegrator complex subunit 4progesterone receptor
SynonymsINT4|MST093NR3C3|PR
Cytomap

11q14.1

11q22.1

Type of geneprotein-codingprotein-coding
Descriptionintegrator complex subunit 4MSTP093progesterone receptornuclear receptor subfamily 3 group C member 3
Modification date2018052320180520
UniProtAcc

Q96HW7

P06401

Ensembl transtripts involved in fusion geneENST00000534064, ENST00000535943, 
ENST00000525931, ENST00000529807, 
ENST00000527522, 		ENST00000325455, 
ENST00000534013, ENST00000263463, 
Fusion gene scores* DoF score17 X 9 X 9=13773 X 2 X 3=18
# samples 183
** MAII scorelog2(18/1377*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: INTS4 [Title/Abstract] AND PGR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneINTS4

GO:0016180

snRNA processing

16239144

TgenePGR

GO:0045944

positive regulation of transcription by RNA polymerase II

17785366


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-GN-A26D-06AINTS4chr11

77666988

-PGRchr11

100962607

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000534064ENST00000325455INTS4chr11

77666988

-PGRchr11

100962607

-
Frame-shiftENST00000534064ENST00000534013INTS4chr11

77666988

-PGRchr11

100962607

-
Frame-shiftENST00000534064ENST00000263463INTS4chr11

77666988

-PGRchr11

100962607

-
intron-3CDSENST00000535943ENST00000325455INTS4chr11

77666988

-PGRchr11

100962607

-
intron-3CDSENST00000535943ENST00000534013INTS4chr11

77666988

-PGRchr11

100962607

-
intron-3CDSENST00000535943ENST00000263463INTS4chr11

77666988

-PGRchr11

100962607

-
intron-3CDSENST00000525931ENST00000325455INTS4chr11

77666988

-PGRchr11

100962607

-
intron-3CDSENST00000525931ENST00000534013INTS4chr11

77666988

-PGRchr11

100962607

-
intron-3CDSENST00000525931ENST00000263463INTS4chr11

77666988

-PGRchr11

100962607

-
Frame-shiftENST00000529807ENST00000325455INTS4chr11

77666988

-PGRchr11

100962607

-
Frame-shiftENST00000529807ENST00000534013INTS4chr11

77666988

-PGRchr11

100962607

-
Frame-shiftENST00000529807ENST00000263463INTS4chr11

77666988

-PGRchr11

100962607

-
intron-3CDSENST00000527522ENST00000325455INTS4chr11

77666988

-PGRchr11

100962607

-
intron-3CDSENST00000527522ENST00000534013INTS4chr11

77666988

-PGRchr11

100962607

-
intron-3CDSENST00000527522ENST00000263463INTS4chr11

77666988

-PGRchr11

100962607

-

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FusionProtFeatures for INTS4_PGR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INTS4

Q96HW7

PGR

P06401

Component of the Integrator (INT) complex, a complexinvolved in the small nuclear RNAs (snRNA) U1 and U2 transcriptionand in their 3'-box-dependent processing. The Integrator complexis associated with the C-terminal domain (CTD) of RNA polymeraseII largest subunit (POLR2A) and is recruited to the U1 and U2snRNAs genes (Probable). Mediates recruitment of cytoplasmicdynein to the nuclear envelope, probably as component of the INTcomplex (PubMed:23904267). {ECO:0000269|PubMed:23904267,ECO:0000305|PubMed:16239144}. The steroid hormones and their receptors are involved inthe regulation of eukaryotic gene expression and affect cellularproliferation and differentiation in target tissues. Depending onthe isoform, progesterone receptor functions as transcriptionalactivator or repressor. {ECO:0000269|PubMed:10757795,ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:9407067,ECO:0000305}. Isoform A: Ligand-dependent transdominant repressor ofsteroid hormone receptor transcriptional activity includingrepression of its isoform B, MR and ER. Transrepressional activitymay involve recruitment of corepressor NCOR2.{ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103,ECO:0000269|PubMed:8264658, ECO:0000305,ECO:0000305|PubMed:10757795}. Isoform B: Transcriptional activator of severalprogesteron-dependent promoters in a variety of cell types.Involved in activation of SRC-dependent MAPK signaling on hormonestimulation. {ECO:0000269|PubMed:7969170}. Isoform 4: Increases mitochondrial membrane potentialand cellular respiration upon stimulation by progesterone.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for INTS4_PGR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INTS4_PGR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INTS4RPAP2, INTS1, INTS3, INTS5, INTS6, SHFM1, INTS10, INTS9, HECW2, HGS, ZMIZ2, USHBP1, HLA-B, SLAMF1, VSIG4, LOC554223, ISLR, INTS4P2, TGOLN2, FAF2, C7orf26, CPSF3L, FAM98A, ASUN, NTRK1, PPP2CA, PPP2CB, PPP2R1A, VWA9, SIGLECL1, BMP2K, VSIG1, PMEL, PDCD1, CD70, GORASP1, AP2A1, CD79B, SIGLEC5, ADAM32, PCDHA12, AP2A2, CLEC2DPGRUBE3A, SMARCD1, TDG, KLF9, CDC25B, POU2F1, POU2F2, DAP3, UBR5, RELA, FKBP5, NCOA1, DDX54, RNF4, PIAS2, HMGB1, HMGB2, NCOR2, NCOA3, CUEDC2, NCOR1, MAPK1, SMARCE1, ARID1A, SMARCA1, GNAI1, NR0B1, EP300, TAF1B, SP1, PRDM2, FGFR2, STAT5A, STAT5B, BRCA1, BATF3, JDP2, STAT3, NCOA2, KAT2B, CCNA1, CDK2, SRC, ESR1, COPS5, BPTF, STUB1, FKBP4, PPP5C, DNAJC7, MAGEA11, RBM23, RBM39, ANP32A, XRCC6, XRCC5, PRKDC, PARP1, PGR, BCAS2, SGTA, SPOP, DNAJA1, HSPA1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INTS4_PGR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePGRP06401DB00304DesogestrelProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB00421SpironolactoneProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB00648MitotaneProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB00717NorethisteroneProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB01395DrospirenoneProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB01406DanazolProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB01431AllylestrenolProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB08867UlipristalProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB09123DienogestProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB09124MedrogestoneProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB09389NorgestrelProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB11619GestrinoneProgesterone receptorsmall moleculeapproved
TgenePGRP06401DB00294EtonogestrelProgesterone receptorsmall moleculeapproved|investigational
TgenePGRP06401DB00367LevonorgestrelProgesterone receptorsmall moleculeapproved|investigational
TgenePGRP06401DB00603Medroxyprogesterone acetateProgesterone receptorsmall moleculeapproved|investigational
TgenePGRP06401DB00834MifepristoneProgesterone receptorsmall moleculeapproved|investigational
TgenePGRP06401DB00957NorgestimateProgesterone receptorsmall moleculeapproved|investigational
TgenePGRP06401DB06713NorelgestrominProgesterone receptorsmall moleculeapproved|investigational
TgenePGRP06401DB06789Hydroxyprogesterone caproateProgesterone receptorsmall moleculeapproved|investigational
TgenePGRP06401DB00351Megestrol acetateProgesterone receptorsmall moleculeapproved|investigational|vet_approved
TgenePGRP06401DB00378DydrogesteroneProgesterone receptorsmall moleculeapproved|investigational|withdrawn
TgenePGRP06401DB00396ProgesteroneProgesterone receptorsmall moleculeapproved|vet_approved
TgenePGRP06401DB00764MometasoneProgesterone receptorsmall moleculeapproved|vet_approved
TgenePGRP06401DB00431LindaneProgesterone receptorsmall moleculeapproved|withdrawn

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RelatedDiseases for INTS4_PGR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneINTS4C0033578Prostatic Neoplasms1CTD_human
TgenePGRC0025286Meningioma3CTD_human
TgenePGRC0014175Endometriosis2CTD_human
TgenePGRC1458155Mammary Neoplasms2CTD_human
TgenePGRC0001418Adenocarcinoma1CTD_human
TgenePGRC0014170Endometrial Neoplasms1CTD_human
TgenePGRC0024667Animal Mammary Neoplasms1CTD_human
TgenePGRC0024668Mammary Neoplasms, Experimental1CTD_human
TgenePGRC0025500Mesothelioma1CTD_human