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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17581

FusionGeneSummary for INTS4_GAB2

check button Fusion gene summary
Fusion gene informationFusion gene name: INTS4_GAB2
Fusion gene ID: 17581
HgeneTgene
Gene symbol

INTS4

GAB2

Gene ID

92105

9846

Gene nameintegrator complex subunit 4GRB2 associated binding protein 2
SynonymsINT4|MST093-
Cytomap

11q14.1

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionintegrator complex subunit 4MSTP093GRB2-associated-binding protein 2Grb2-associated binder 2growth factor receptor bound protein 2-associated protein 2pp100
Modification date2018052320180527
UniProtAcc

Q96HW7

Q9UQC2

Ensembl transtripts involved in fusion geneENST00000534064, ENST00000535943, 
ENST00000525931, ENST00000529807, 
ENST00000527522, 
ENST00000340149, 
ENST00000361507, ENST00000526030, 
Fusion gene scores* DoF score17 X 9 X 9=137711 X 6 X 3=198
# samples 1814
** MAII scorelog2(18/1377*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/198*10)=-0.500073603134643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: INTS4 [Title/Abstract] AND GAB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneINTS4

GO:0016180

snRNA processing

16239144

TgeneGAB2

GO:0008284

positive regulation of cell proliferation

19172738


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AC-A2BM-01AINTS4chr11

77690042

-GAB2chr11

77991947

-
TCGALDBRCATCGA-A2-A0CL-01AINTS4chr11

77594878

-GAB2chr11

77938097

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000534064ENST00000340149INTS4chr11

77690042

-GAB2chr11

77991947

-
5CDS-5UTRENST00000534064ENST00000361507INTS4chr11

77690042

-GAB2chr11

77991947

-
5CDS-5UTRENST00000534064ENST00000526030INTS4chr11

77690042

-GAB2chr11

77991947

-
intron-5UTRENST00000535943ENST00000340149INTS4chr11

77690042

-GAB2chr11

77991947

-
intron-5UTRENST00000535943ENST00000361507INTS4chr11

77690042

-GAB2chr11

77991947

-
intron-5UTRENST00000535943ENST00000526030INTS4chr11

77690042

-GAB2chr11

77991947

-
intron-5UTRENST00000525931ENST00000340149INTS4chr11

77690042

-GAB2chr11

77991947

-
intron-5UTRENST00000525931ENST00000361507INTS4chr11

77690042

-GAB2chr11

77991947

-
intron-5UTRENST00000525931ENST00000526030INTS4chr11

77690042

-GAB2chr11

77991947

-
5CDS-5UTRENST00000529807ENST00000340149INTS4chr11

77690042

-GAB2chr11

77991947

-
5CDS-5UTRENST00000529807ENST00000361507INTS4chr11

77690042

-GAB2chr11

77991947

-
5CDS-5UTRENST00000529807ENST00000526030INTS4chr11

77690042

-GAB2chr11

77991947

-
intron-5UTRENST00000527522ENST00000340149INTS4chr11

77690042

-GAB2chr11

77991947

-
intron-5UTRENST00000527522ENST00000361507INTS4chr11

77690042

-GAB2chr11

77991947

-
intron-5UTRENST00000527522ENST00000526030INTS4chr11

77690042

-GAB2chr11

77991947

-
Frame-shitENST00000534064ENST00000340149INTS4chr11

77594878

-GAB2chr11

77938097

-
Frame-shitENST00000534064ENST00000361507INTS4chr11

77594878

-GAB2chr11

77938097

-
5CDS-5UTRENST00000534064ENST00000526030INTS4chr11

77594878

-GAB2chr11

77938097

-
Frame-shitENST00000535943ENST00000340149INTS4chr11

77594878

-GAB2chr11

77938097

-
Frame-shitENST00000535943ENST00000361507INTS4chr11

77594878

-GAB2chr11

77938097

-
5CDS-5UTRENST00000535943ENST00000526030INTS4chr11

77594878

-GAB2chr11

77938097

-
intron-3CDSENST00000525931ENST00000340149INTS4chr11

77594878

-GAB2chr11

77938097

-
intron-3CDSENST00000525931ENST00000361507INTS4chr11

77594878

-GAB2chr11

77938097

-
intron-5UTRENST00000525931ENST00000526030INTS4chr11

77594878

-GAB2chr11

77938097

-
intron-3CDSENST00000529807ENST00000340149INTS4chr11

77594878

-GAB2chr11

77938097

-
intron-3CDSENST00000529807ENST00000361507INTS4chr11

77594878

-GAB2chr11

77938097

-
intron-5UTRENST00000529807ENST00000526030INTS4chr11

77594878

-GAB2chr11

77938097

-
intron-3CDSENST00000527522ENST00000340149INTS4chr11

77594878

-GAB2chr11

77938097

-
intron-3CDSENST00000527522ENST00000361507INTS4chr11

77594878

-GAB2chr11

77938097

-
intron-5UTRENST00000527522ENST00000526030INTS4chr11

77594878

-GAB2chr11

77938097

-

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FusionProtFeatures for INTS4_GAB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INTS4

Q96HW7

GAB2

Q9UQC2

Component of the Integrator (INT) complex, a complexinvolved in the small nuclear RNAs (snRNA) U1 and U2 transcriptionand in their 3'-box-dependent processing. The Integrator complexis associated with the C-terminal domain (CTD) of RNA polymeraseII largest subunit (POLR2A) and is recruited to the U1 and U2snRNAs genes (Probable). Mediates recruitment of cytoplasmicdynein to the nuclear envelope, probably as component of the INTcomplex (PubMed:23904267). {ECO:0000269|PubMed:23904267,ECO:0000305|PubMed:16239144}. Adapter protein which acts downstream of severalmembrane receptors including cytokine, antigen, hormone, cellmatrix and growth factor receptors to regulate multiple signalingpathways. Regulates osteoclast differentiation mediating theTNFRSF11A/RANK signaling. In allergic response, it plays a role inmast cells activation and degranulation through PI-3-kinaseregulation. Also involved in the regulation of cell proliferationand hematopoiesis. {ECO:0000269|PubMed:15750601,ECO:0000269|PubMed:19172738}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for INTS4_GAB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INTS4_GAB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INTS4RPAP2, INTS1, INTS3, INTS5, INTS6, SHFM1, INTS10, INTS9, HECW2, HGS, ZMIZ2, USHBP1, HLA-B, SLAMF1, VSIG4, LOC554223, ISLR, INTS4P2, TGOLN2, FAF2, C7orf26, CPSF3L, FAM98A, ASUN, NTRK1, PPP2CA, PPP2CB, PPP2R1A, VWA9, SIGLECL1, BMP2K, VSIG1, PMEL, PDCD1, CD70, GORASP1, AP2A1, CD79B, SIGLEC5, ADAM32, PCDHA12, AP2A2, CLEC2DGAB2BCR, GRB2, ETV6, ARHGAP32, LYN, PLCG2, PTPN11, SHC1, ZAP70, CD247, LAT, PTPN6, PIK3R1, AKT1, GRAP, SRC, NCK1, PLCG1, CRKL, MET, GRAP2, LRRK1, PIK3R2, CRK, PIK3CB, MAPK1, MAPK3, MARK2, GAB1, GAB2, YWHAE, NTRK1, XPO1, FRS2, TGM4, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, RTKN, MAST3, SYDE1, PPM1H, AGAP1, CDC25B, CDK16, FAM110B, USP21, ANKRD34A, FAM53C, CGN, FAM110A, DENND4C, HDAC4, MAPKAP1, TBC1D25, NF1, NADK, CBY1, RAB3IP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INTS4_GAB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for INTS4_GAB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneINTS4C0033578Prostatic Neoplasms1CTD_human
TgeneGAB2C0025202melanoma1CTD_human
TgeneGAB2C0027626Neoplasm Invasiveness1CTD_human
TgeneGAB2C0027627Neoplasm Metastasis1CTD_human