FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17580

FusionGeneSummary for INTS4_C11orf30

check button Fusion gene summary
Fusion gene informationFusion gene name: INTS4_C11orf30
Fusion gene ID: 17580
HgeneTgene
Gene symbol

INTS4

C11orf30

Gene ID

92105

56946

Gene nameintegrator complex subunit 4EMSY, BRCA2 interacting transcriptional repressor
SynonymsINT4|MST093C11orf30|GL002
Cytomap

11q14.1

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionintegrator complex subunit 4MSTP093BRCA2-interacting transcriptional repressor EMSYprotein EMSY
Modification date2018052320180519
UniProtAcc

Q96HW7

Ensembl transtripts involved in fusion geneENST00000534064, ENST00000535943, 
ENST00000525931, ENST00000529807, 
ENST00000527522, 		ENST00000533988, 
ENST00000524490, ENST00000334736, 
ENST00000343878, ENST00000525959, 
ENST00000533248, ENST00000525919, 
ENST00000524767, ENST00000525038, 
ENST00000529032, 
Fusion gene scores* DoF score17 X 9 X 9=13775 X 5 X 4=100
# samples 185
** MAII scorelog2(18/1377*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: INTS4 [Title/Abstract] AND C11orf30 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneINTS4

GO:0016180

snRNA processing

16239144


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A079-01AINTS4chr11

77612467

-C11orf30chr11

76253260

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000534064ENST00000533988INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000534064ENST00000524490INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000534064ENST00000334736INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000534064ENST00000343878INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000534064ENST00000525959INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000534064ENST00000533248INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000534064ENST00000525919INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000534064ENST00000524767INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000534064ENST00000525038INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000534064ENST00000529032INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000535943ENST00000533988INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000535943ENST00000524490INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000535943ENST00000334736INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000535943ENST00000343878INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000535943ENST00000525959INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000535943ENST00000533248INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000535943ENST00000525919INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000535943ENST00000524767INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000535943ENST00000525038INTS4chr11

77612467

-C11orf30chr11

76253260

+
5CDS-intronENST00000535943ENST00000529032INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000525931ENST00000533988INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000525931ENST00000524490INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000525931ENST00000334736INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000525931ENST00000343878INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000525931ENST00000525959INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000525931ENST00000533248INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000525931ENST00000525919INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000525931ENST00000524767INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000525931ENST00000525038INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000525931ENST00000529032INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000529807ENST00000533988INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000529807ENST00000524490INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000529807ENST00000334736INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000529807ENST00000343878INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000529807ENST00000525959INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000529807ENST00000533248INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000529807ENST00000525919INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000529807ENST00000524767INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000529807ENST00000525038INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000529807ENST00000529032INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000527522ENST00000533988INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000527522ENST00000524490INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000527522ENST00000334736INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000527522ENST00000343878INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000527522ENST00000525959INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000527522ENST00000533248INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000527522ENST00000525919INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000527522ENST00000524767INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000527522ENST00000525038INTS4chr11

77612467

-C11orf30chr11

76253260

+
intron-intronENST00000527522ENST00000529032INTS4chr11

77612467

-C11orf30chr11

76253260

+

Top

FusionProtFeatures for INTS4_C11orf30


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INTS4

Q96HW7

C11orf30

Component of the Integrator (INT) complex, a complexinvolved in the small nuclear RNAs (snRNA) U1 and U2 transcriptionand in their 3'-box-dependent processing. The Integrator complexis associated with the C-terminal domain (CTD) of RNA polymeraseII largest subunit (POLR2A) and is recruited to the U1 and U2snRNAs genes (Probable). Mediates recruitment of cytoplasmicdynein to the nuclear envelope, probably as component of the INTcomplex (PubMed:23904267). {ECO:0000269|PubMed:23904267,ECO:0000305|PubMed:16239144}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for INTS4_C11orf30


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for INTS4_C11orf30


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INTS4RPAP2, INTS1, INTS3, INTS5, INTS6, SHFM1, INTS10, INTS9, HECW2, HGS, ZMIZ2, USHBP1, HLA-B, SLAMF1, VSIG4, LOC554223, ISLR, INTS4P2, TGOLN2, FAF2, C7orf26, CPSF3L, FAM98A, ASUN, NTRK1, PPP2CA, PPP2CB, PPP2R1A, VWA9, SIGLECL1, BMP2K, VSIG1, PMEL, PDCD1, CD70, GORASP1, AP2A1, CD79B, SIGLEC5, ADAM32, PCDHA12, AP2A2, CLEC2DC11orf30BRCA2, CBX1, ZMYND11, ZNF335, ASH2L, CCAR2, RBBP5, TADA2A, HDAC1, HDAC2, DDIT3, ZNF646, MOV10, NXF1, HIST3H3, GATAD1, TMEM171, MORF4L1, DYNLT1, CSNK2A2, TRIM26, SIN3B, RTEL1, PHF12, KIF7, FOXJ2, FOXK2, ZNF281, KDM5A, ZNF131, MORF4L2, RBBP7, C11orf30, QSER1, CHD9, AKAP8, BCAS2, KRT18, SNRPA1, SON, NUP214, HNRNPM, NUP98, PHC3, NUP88, NCAPH2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for INTS4_C11orf30


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for INTS4_C11orf30


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneINTS4C0033578Prostatic Neoplasms1CTD_human