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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17571

FusionGeneSummary for INTS1_SUN1

check button Fusion gene summary
Fusion gene informationFusion gene name: INTS1_SUN1
Fusion gene ID: 17571
HgeneTgene
Gene symbol

INTS1

SUN1

Gene ID

26173

23353

Gene nameintegrator complex subunit 1Sad1 and UNC84 domain containing 1
SynonymsINT1|NET28UNC84A
Cytomap

7p22.3

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionintegrator complex subunit 1SUN domain-containing protein 1Sad1 unc-84 domain protein 1protein unc-84 homolog Asad1/unc-84 protein-like 1unc-84 homolog A
Modification date2018052320180523
UniProtAcc

Q8N201

O94901

Ensembl transtripts involved in fusion geneENST00000404767, ENST00000389470, 
ENST00000493531, 		ENST00000456758, 
ENST00000457378, ENST00000389574, 
ENST00000452783, ENST00000405266, 
ENST00000401592, ENST00000403868, 
ENST00000425407, ENST00000469755, 
ENST00000413514, 
Fusion gene scores* DoF score6 X 5 X 3=902 X 2 X 2=8
# samples 62
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: INTS1 [Title/Abstract] AND SUN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneINTS1

GO:0016180

snRNA processing

16239144

TgeneSUN1

GO:0090286

cytoskeletal anchoring at nuclear membrane

18396275

TgeneSUN1

GO:0090292

nuclear matrix anchoring at nuclear membrane

18396275


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-EJ-5497-01AINTS1chr7

1510482

-SUN1chr7

930565

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000404767ENST00000456758INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000404767ENST00000457378INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000404767ENST00000389574INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000404767ENST00000452783INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000404767ENST00000405266INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000404767ENST00000401592INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000404767ENST00000403868INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000404767ENST00000425407INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000404767ENST00000469755INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000404767ENST00000413514INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000389470ENST00000456758INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000389470ENST00000457378INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000389470ENST00000389574INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000389470ENST00000452783INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000389470ENST00000405266INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000389470ENST00000401592INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000389470ENST00000403868INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000389470ENST00000425407INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000389470ENST00000469755INTS1chr7

1510482

-SUN1chr7

930565

+
5CDS-intronENST00000389470ENST00000413514INTS1chr7

1510482

-SUN1chr7

930565

+
intron-intronENST00000493531ENST00000456758INTS1chr7

1510482

-SUN1chr7

930565

+
intron-intronENST00000493531ENST00000457378INTS1chr7

1510482

-SUN1chr7

930565

+
intron-intronENST00000493531ENST00000389574INTS1chr7

1510482

-SUN1chr7

930565

+
intron-intronENST00000493531ENST00000452783INTS1chr7

1510482

-SUN1chr7

930565

+
intron-intronENST00000493531ENST00000405266INTS1chr7

1510482

-SUN1chr7

930565

+
intron-intronENST00000493531ENST00000401592INTS1chr7

1510482

-SUN1chr7

930565

+
intron-intronENST00000493531ENST00000403868INTS1chr7

1510482

-SUN1chr7

930565

+
intron-intronENST00000493531ENST00000425407INTS1chr7

1510482

-SUN1chr7

930565

+
intron-intronENST00000493531ENST00000469755INTS1chr7

1510482

-SUN1chr7

930565

+
intron-intronENST00000493531ENST00000413514INTS1chr7

1510482

-SUN1chr7

930565

+

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FusionProtFeatures for INTS1_SUN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INTS1

Q8N201

SUN1

O94901


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for INTS1_SUN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INTS1_SUN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INTS1RPAP2, TCEA1, RPAP3, INTS2, INTS3, INTS4, INTS5, INTS6, DDX26B, INTS7, INTS8, INTS9, INTS10, CPSF3L, INTS12, POLR2A, POLR2B, POLR2H, PPP2R1A, PPP2R1B, PPP1CB, PPP2CA, PPP2CB, ASUN, VWA9, C7orf26, NABP2, ZMYND8, ZNF687, CTDP1, SIRT7, SOX2, RPA3, RPA2, RPA1, CCDC8, EED, KIR2DS2, SLAMF1, ST8SIA1, TGOLN2, IQCF1, ALDH3A2, NTRK1, SKA1, USP43, SNW1, CDC5L, OPRM1, APLNR, NDUFS7, ILVBL, NPY2R, MTNR1BSUN1SYNE1, SYNE2, FBXO6, OBSL1, ZNF507, TYW5, TRIP6, CLEC12A, TEX264, ZACN, HTR3C, SCARA3, IFI16, TCTN3, TMEM216, CTDNEP1, DPEP1, CAPN6, LRRTM1, MPPE1, ZNRF4, CSGALNACT2, KCNS3, FBXO28, TRIM25, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INTS1_SUN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for INTS1_SUN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource