FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17552

FusionGeneSummary for INS-IGF2_TM2D1

check button Fusion gene summary
Fusion gene informationFusion gene name: INS-IGF2_TM2D1
Fusion gene ID: 17552
HgeneTgene
Gene symbol

INS-IGF2

TM2D1

Gene ID

723961

83941

Gene nameINS-IGF2 readthroughTM2 domain containing 1
SynonymsINSIGFBBP
Cytomap

11p15.5

1p31.3

Type of geneprotein-codingprotein-coding
Descriptioninsulin, isoform 2INS-IGF2 readthrough transcript proteininsulin- insulin-like growth factor 2 read-through productTM2 domain-containing protein 1Beta-amyloid peptide binding proteinamyloid-beta-binding proteinbeta-amyloid-binding proteinhBBP
Modification date2018052220180523
UniProtAcc

F8WCM5

Q9BX74

Ensembl transtripts involved in fusion geneENST00000481781, ENST00000397270, 
ENST00000606498, ENST00000294613, 
ENST00000371180, ENST00000472989, 
ENST00000371177, 
Fusion gene scores* DoF score22 X 31 X 1=6824 X 4 X 2=32
# samples 334
** MAII scorelog2(33/682*10)=-1.04730571477836
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: INS-IGF2 [Title/Abstract] AND TM2D1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM509290INS-IGF2chr11

2182411

+TM2D1chr1

62190787

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000481781ENST00000606498INS-IGF2chr11

2182411

+TM2D1chr1

62190787

-
intron-3CDSENST00000481781ENST00000294613INS-IGF2chr11

2182411

+TM2D1chr1

62190787

-
intron-3CDSENST00000481781ENST00000371180INS-IGF2chr11

2182411

+TM2D1chr1

62190787

-
intron-intronENST00000481781ENST00000472989INS-IGF2chr11

2182411

+TM2D1chr1

62190787

-
intron-intronENST00000481781ENST00000371177INS-IGF2chr11

2182411

+TM2D1chr1

62190787

-
intron-3CDSENST00000397270ENST00000606498INS-IGF2chr11

2182411

+TM2D1chr1

62190787

-
intron-3CDSENST00000397270ENST00000294613INS-IGF2chr11

2182411

+TM2D1chr1

62190787

-
intron-3CDSENST00000397270ENST00000371180INS-IGF2chr11

2182411

+TM2D1chr1

62190787

-
intron-intronENST00000397270ENST00000472989INS-IGF2chr11

2182411

+TM2D1chr1

62190787

-
intron-intronENST00000397270ENST00000371177INS-IGF2chr11

2182411

+TM2D1chr1

62190787

-

Top

FusionProtFeatures for INS-IGF2_TM2D1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INS-IGF2

F8WCM5

TM2D1

Q9BX74

May participate in amyloid-beta-induced apoptosis viaits interaction with beta-APP42. {ECO:0000269|PubMed:11278849,ECO:0000269|PubMed:12836168}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for INS-IGF2_TM2D1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for INS-IGF2_TM2D1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for INS-IGF2_TM2D1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for INS-IGF2_TM2D1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource