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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1755

FusionGeneSummary for ANKRD10_PAQR4

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD10_PAQR4
Fusion gene ID: 1755
HgeneTgene
Gene symbol

ANKRD10

PAQR4

Gene ID

55608

124222

Gene nameankyrin repeat domain 10progestin and adipoQ receptor family member 4
Synonyms--
Cytomap

13q34

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 10progestin and adipoQ receptor family member 4progestin and adipoQ receptor family member IV
Modification date2018051920180519
UniProtAcc

Q9NXR5

Q8N4S7

Ensembl transtripts involved in fusion geneENST00000267339, ENST00000375758, 
ENST00000489973, ENST00000310847, 
ENST00000318782, ENST00000293978, 
ENST00000576565, ENST00000572687, 
ENST00000574988, 
Fusion gene scores* DoF score6 X 5 X 2=603 X 3 X 1=9
# samples 63
** MAII scorelog2(6/60*10)=0log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANKRD10 [Title/Abstract] AND PAQR4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC011843ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000267339ENST00000318782ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000267339ENST00000293978ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000267339ENST00000576565ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000267339ENST00000572687ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000267339ENST00000574988ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000375758ENST00000318782ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000375758ENST00000293978ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000375758ENST00000576565ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000375758ENST00000572687ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000375758ENST00000574988ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5UTR-intronENST00000489973ENST00000318782ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5UTR-intronENST00000489973ENST00000293978ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5UTR-intronENST00000489973ENST00000576565ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5UTR-intronENST00000489973ENST00000572687ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5UTR-intronENST00000489973ENST00000574988ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000310847ENST00000318782ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000310847ENST00000293978ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000310847ENST00000576565ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000310847ENST00000572687ANKRD10chr13

111558380

-PAQR4chr16

3024657

-
5CDS-intronENST00000310847ENST00000574988ANKRD10chr13

111558380

-PAQR4chr16

3024657

-

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FusionProtFeatures for ANKRD10_PAQR4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD10

Q9NXR5

PAQR4

Q8N4S7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKRD10_PAQR4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKRD10_PAQR4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKRD10_PAQR4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKRD10_PAQR4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource