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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17510

FusionGeneSummary for INPP5A_LRRC27

check button Fusion gene summary
Fusion gene informationFusion gene name: INPP5A_LRRC27
Fusion gene ID: 17510
HgeneTgene
Gene symbol

INPP5A

LRRC27

Gene ID

3632

80313

Gene nameinositol polyphosphate-5-phosphatase Aleucine rich repeat containing 27
Synonyms5PTASE-
Cytomap

10q26.3

10q26.3

Type of geneprotein-codingprotein-coding
Descriptiontype I inositol 1,4,5-trisphosphate 5-phosphatase43 kDa inositol polyphosphate 5-phophataseCTCL tumor antigen HD-CL-02InsP3 5-phosphataseinositol polyphosphate-5-phosphatase, 40kDinositol polyphosphate-5-phosphatase, 40kDainositol trisphosphate-5-phleucine-rich repeat-containing protein 27testicular tissue protein Li 108
Modification date2018052320180523
UniProtAcc

Q14642

Q9C0I9

Ensembl transtripts involved in fusion geneENST00000368594, ENST00000368593, 
ENST00000487614, 		ENST00000368615, 
ENST00000392638, ENST00000344079, 
ENST00000356571, ENST00000368614, 
ENST00000368613, ENST00000368612, 
ENST00000368610, ENST00000432555, 
ENST00000475747, 
Fusion gene scores* DoF score11 X 6 X 8=5284 X 4 X 6=96
# samples 126
** MAII scorelog2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: INPP5A [Title/Abstract] AND LRRC27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1918-01AINPP5Achr10

134351675

+LRRC27chr10

134174961

+
TCGARVSKCMTCGA-D3-A2J6-06AINPP5Achr10

134421460

+LRRC27chr10

134174961

+
TCGARVUCSTCGA-NF-A4WU-01AINPP5Achr10

134351675

+LRRC27chr10

134161488

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000368594ENST00000368615INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-3UTRENST00000368594ENST00000392638INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000344079INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000356571INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000368614INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000368613INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000368612INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000368610INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000432555INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-3UTRENST00000368594ENST00000475747INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000368615INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-3UTRENST00000368593ENST00000392638INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000344079INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000356571INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000368614INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000368613INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000368612INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000368610INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000432555INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-3UTRENST00000368593ENST00000475747INPP5Achr10

134351675

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000368615INPP5Achr10

134351675

+LRRC27chr10

134174961

+
intron-3UTRENST00000487614ENST00000392638INPP5Achr10

134351675

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000344079INPP5Achr10

134351675

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000356571INPP5Achr10

134351675

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000368614INPP5Achr10

134351675

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000368613INPP5Achr10

134351675

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000368612INPP5Achr10

134351675

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000368610INPP5Achr10

134351675

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000432555INPP5Achr10

134351675

+LRRC27chr10

134174961

+
intron-3UTRENST00000487614ENST00000475747INPP5Achr10

134351675

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000368615INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-3UTRENST00000368594ENST00000392638INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000344079INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000356571INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000368614INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000368613INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000368612INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000368610INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368594ENST00000432555INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-3UTRENST00000368594ENST00000475747INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000368615INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-3UTRENST00000368593ENST00000392638INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000344079INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000356571INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000368614INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000368613INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000368612INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000368610INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-intronENST00000368593ENST00000432555INPP5Achr10

134421460

+LRRC27chr10

134174961

+
5CDS-3UTRENST00000368593ENST00000475747INPP5Achr10

134421460

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000368615INPP5Achr10

134421460

+LRRC27chr10

134174961

+
intron-3UTRENST00000487614ENST00000392638INPP5Achr10

134421460

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000344079INPP5Achr10

134421460

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000356571INPP5Achr10

134421460

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000368614INPP5Achr10

134421460

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000368613INPP5Achr10

134421460

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000368612INPP5Achr10

134421460

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000368610INPP5Achr10

134421460

+LRRC27chr10

134174961

+
intron-intronENST00000487614ENST00000432555INPP5Achr10

134421460

+LRRC27chr10

134174961

+
intron-3UTRENST00000487614ENST00000475747INPP5Achr10

134421460

+LRRC27chr10

134174961

+
Frame-shiftENST00000368594ENST00000368615INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368594ENST00000392638INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368594ENST00000344079INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368594ENST00000356571INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368594ENST00000368614INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368594ENST00000368613INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368594ENST00000368612INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368594ENST00000368610INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368594ENST00000432555INPP5Achr10

134351675

+LRRC27chr10

134161488

+
5CDS-intronENST00000368594ENST00000475747INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368593ENST00000368615INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368593ENST00000392638INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368593ENST00000344079INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368593ENST00000356571INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368593ENST00000368614INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368593ENST00000368613INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368593ENST00000368612INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368593ENST00000368610INPP5Achr10

134351675

+LRRC27chr10

134161488

+
Frame-shiftENST00000368593ENST00000432555INPP5Achr10

134351675

+LRRC27chr10

134161488

+
5CDS-intronENST00000368593ENST00000475747INPP5Achr10

134351675

+LRRC27chr10

134161488

+
intron-3CDSENST00000487614ENST00000368615INPP5Achr10

134351675

+LRRC27chr10

134161488

+
intron-3CDSENST00000487614ENST00000392638INPP5Achr10

134351675

+LRRC27chr10

134161488

+
intron-3CDSENST00000487614ENST00000344079INPP5Achr10

134351675

+LRRC27chr10

134161488

+
intron-3CDSENST00000487614ENST00000356571INPP5Achr10

134351675

+LRRC27chr10

134161488

+
intron-3CDSENST00000487614ENST00000368614INPP5Achr10

134351675

+LRRC27chr10

134161488

+
intron-3CDSENST00000487614ENST00000368613INPP5Achr10

134351675

+LRRC27chr10

134161488

+
intron-3CDSENST00000487614ENST00000368612INPP5Achr10

134351675

+LRRC27chr10

134161488

+
intron-3CDSENST00000487614ENST00000368610INPP5Achr10

134351675

+LRRC27chr10

134161488

+
intron-3CDSENST00000487614ENST00000432555INPP5Achr10

134351675

+LRRC27chr10

134161488

+
intron-intronENST00000487614ENST00000475747INPP5Achr10

134351675

+LRRC27chr10

134161488

+

Top

FusionProtFeatures for INPP5A_LRRC27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INPP5A

Q14642

LRRC27

Q9C0I9

Major isoenzyme hydrolyzing the calcium-mobilizingsecond messenger Ins(1,4,5)P3, this is a signal-terminatingreaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for INPP5A_LRRC27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for INPP5A_LRRC27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INPP5AYWHAZ, RABGGTB, TTC1, RCCD1, ZG16B, ITFG2, IGHA1, SLC25A41, DUSP22, ISOC2, MED21, PRPS2LRRC27HMOX1, MCM8, SCRIB, IFT52, LRRC40, POLA2, WDR19, BBS7, PJA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for INPP5A_LRRC27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for INPP5A_LRRC27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneINPP5AC0007137Squamous cell carcinoma1CTD_human
HgeneINPP5AC0036341Schizophrenia1CTD_human
HgeneINPP5AC0037274Dermatologic disorders1CTD_human
HgeneINPP5AC0311375Arsenic Poisoning1CTD_human