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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17509

FusionGeneSummary for INPP5A_KIF20B

check button Fusion gene summary
Fusion gene informationFusion gene name: INPP5A_KIF20B
Fusion gene ID: 17509
HgeneTgene
Gene symbol

INPP5A

KIF20B

Gene ID

3632

9585

Gene nameinositol polyphosphate-5-phosphatase Akinesin family member 20B
Synonyms5PTASECT90|KRMP1|MPHOSPH1|MPP-1|MPP1
Cytomap

10q26.3

10q23.31

Type of geneprotein-codingprotein-coding
Descriptiontype I inositol 1,4,5-trisphosphate 5-phosphatase43 kDa inositol polyphosphate 5-phophataseCTCL tumor antigen HD-CL-02InsP3 5-phosphataseinositol polyphosphate-5-phosphatase, 40kDinositol polyphosphate-5-phosphatase, 40kDainositol trisphosphate-5-phkinesin-like protein KIF20BM-phase phosphoprotein 1cancer/testis antigen 90kinesin-related motor interacting with PIN1mitotic kinesin-like proteinmitotic kinesin-related protein
Modification date2018052320180523
UniProtAcc

Q14642

Q96Q89

Ensembl transtripts involved in fusion geneENST00000368594, ENST00000368593, 
ENST00000487614, 
ENST00000394289, 
ENST00000260753, ENST00000416354, 
ENST00000371728, ENST00000478929, 
Fusion gene scores* DoF score11 X 6 X 8=5283 X 3 X 3=27
# samples 123
** MAII scorelog2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: INPP5A [Title/Abstract] AND KIF20B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AO-A03O-01AINPP5Achr10

134579350

+KIF20Bchr10

91512324

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000368594ENST00000394289INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
Frame-shiftENST00000368594ENST00000260753INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
Frame-shiftENST00000368594ENST00000416354INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
Frame-shiftENST00000368594ENST00000371728INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
5CDS-3UTRENST00000368594ENST00000478929INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
Frame-shiftENST00000368593ENST00000394289INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
Frame-shiftENST00000368593ENST00000260753INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
Frame-shiftENST00000368593ENST00000416354INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
Frame-shiftENST00000368593ENST00000371728INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
5CDS-3UTRENST00000368593ENST00000478929INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
intron-3CDSENST00000487614ENST00000394289INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
intron-3CDSENST00000487614ENST00000260753INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
intron-3CDSENST00000487614ENST00000416354INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
intron-3CDSENST00000487614ENST00000371728INPP5Achr10

134579350

+KIF20Bchr10

91512324

+
intron-3UTRENST00000487614ENST00000478929INPP5Achr10

134579350

+KIF20Bchr10

91512324

+

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FusionProtFeatures for INPP5A_KIF20B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INPP5A

Q14642

KIF20B

Q96Q89

Major isoenzyme hydrolyzing the calcium-mobilizingsecond messenger Ins(1,4,5)P3, this is a signal-terminatingreaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for INPP5A_KIF20B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INPP5A_KIF20B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INPP5AYWHAZ, RABGGTB, TTC1, RCCD1, ZG16B, ITFG2, IGHA1, SLC25A41, DUSP22, ISOC2, MED21, PRPS2KIF20BPIN1, ELAVL1, CBX8, CRY1, EEF1G, ACSL3, HSP90B1, CDC42BPA, STAG1, KDM2A, ASTE1, SLC38A2, IMPACT, CCDC94, VCPIP1, CMBL, C1orf52, NANOG, HYPK, CCDC89, NDEL1, TCP10L, MXD3, MLF1, DNAJC7, ID2, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INPP5A_KIF20B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for INPP5A_KIF20B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneINPP5AC0007137Squamous cell carcinoma1CTD_human
HgeneINPP5AC0036341Schizophrenia1CTD_human
HgeneINPP5AC0037274Dermatologic disorders1CTD_human
HgeneINPP5AC0311375Arsenic Poisoning1CTD_human