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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1750

FusionGeneSummary for ANKMY1_SIK3

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKMY1_SIK3
Fusion gene ID: 1750
HgeneTgene
Gene symbol

ANKMY1

SIK3

Gene ID

51281

23387

Gene nameankyrin repeat and MYND domain containing 1SIK family kinase 3
SynonymsZMYND13L19|QSK|SIK-3
Cytomap

2q37.3

11q23.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat and MYND domain-containing protein 1testis-specific ankyrin-like protein 1zinc finger MYND domain-containing protein 13serine/threonine-protein kinase SIK3salt-inducible kinase 3serine/threonine-protein kinase QSK
Modification date2018040320180523
UniProtAcc

Q9P2S6

Q9Y2K2

Ensembl transtripts involved in fusion geneENST00000373318, ENST00000391987, 
ENST00000373320, ENST00000406958, 
ENST00000272972, ENST00000361678, 
ENST00000403283, ENST00000401804, 
ENST00000536462, ENST00000405523, 
ENST00000405002, ENST00000462004, 
ENST00000375300, ENST00000292055, 
ENST00000375288, ENST00000434315, 
ENST00000542607, ENST00000446921, 
ENST00000488337, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 6 X 3=108
# samples 37
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKMY1 [Title/Abstract] AND SIK3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSIK3

GO:0006468

protein phosphorylation

14976552


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AB023216ANKMY1chr2

241497218

-SIK3chr11

116969104

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000373318ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373318ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373318ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373318ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373318ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373318ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373318ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-3CDSENST00000391987ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000391987ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000391987ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000391987ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000391987ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000391987ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000391987ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-3CDSENST00000373320ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373320ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373320ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373320ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373320ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373320ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000373320ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-3CDSENST00000406958ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000406958ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000406958ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000406958ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000406958ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000406958ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000406958ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-3CDSENST00000272972ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000272972ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000272972ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000272972ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000272972ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000272972ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000272972ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-3CDSENST00000361678ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000361678ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000361678ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000361678ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000361678ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000361678ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000361678ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-3CDSENST00000403283ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000403283ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000403283ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000403283ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000403283ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000403283ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000403283ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-3CDSENST00000401804ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000401804ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000401804ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000401804ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000401804ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000401804ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000401804ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-3CDSENST00000536462ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000536462ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000536462ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000536462ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000536462ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000536462ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000536462ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-3CDSENST00000405523ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405523ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405523ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405523ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405523ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405523ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405523ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-3CDSENST00000405002ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405002ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405002ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405002ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405002ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405002ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000405002ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-3CDSENST00000462004ENST00000375300ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000462004ENST00000292055ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000462004ENST00000375288ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000462004ENST00000434315ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000462004ENST00000542607ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000462004ENST00000446921ANKMY1chr2

241497218

-SIK3chr11

116969104

-
intron-intronENST00000462004ENST00000488337ANKMY1chr2

241497218

-SIK3chr11

116969104

-

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FusionProtFeatures for ANKMY1_SIK3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKMY1

Q9P2S6

SIK3

Q9Y2K2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKMY1_SIK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKMY1_SIK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKMY1_SIK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKMY1_SIK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource