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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17497

FusionGeneSummary for INPP4B_GPX3

check button Fusion gene summary
Fusion gene informationFusion gene name: INPP4B_GPX3
Fusion gene ID: 17497
HgeneTgene
Gene symbol

INPP4B

GPX3

Gene ID

8821

2878

Gene nameinositol polyphosphate-4-phosphatase type II Bglutathione peroxidase 3
Synonyms-GPx-P|GSHPx-3|GSHPx-P
Cytomap

4q31.21

5q33.1

Type of geneprotein-codingprotein-coding
Descriptiontype II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDaglutathione peroxidase 3GPx-3extracellular glutathione peroxidaseglutathione peroxidase 3 (plasma)plasma glutathione peroxidase
Modification date2018052320180519
UniProtAcc

O15327

P22352

Ensembl transtripts involved in fusion geneENST00000513000, ENST00000509777, 
ENST00000262992, ENST00000308502, 
ENST00000508116, ENST00000507861, 
ENST00000506217, ENST00000508084, 
ENST00000388825, ENST00000521722, 
ENST00000517973, 
Fusion gene scores* DoF score7 X 7 X 3=1475 X 9 X 2=90
# samples 810
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/90*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: INPP4B [Title/Abstract] AND GPX3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGPX3

GO:0051289

protein homotetramerization

3693360


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB044109INPP4Bchr4

142963356

+GPX3chr5

150406475

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000513000ENST00000388825INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000513000ENST00000521722INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000513000ENST00000517973INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-3CDSENST00000509777ENST00000388825INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000509777ENST00000521722INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000509777ENST00000517973INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-3CDSENST00000262992ENST00000388825INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000262992ENST00000521722INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000262992ENST00000517973INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-3CDSENST00000308502ENST00000388825INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000308502ENST00000521722INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000308502ENST00000517973INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-3CDSENST00000508116ENST00000388825INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000508116ENST00000521722INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000508116ENST00000517973INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-3CDSENST00000507861ENST00000388825INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000507861ENST00000521722INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000507861ENST00000517973INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-3CDSENST00000506217ENST00000388825INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000506217ENST00000521722INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000506217ENST00000517973INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-3CDSENST00000508084ENST00000388825INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000508084ENST00000521722INPP4Bchr4

142963356

+GPX3chr5

150406475

+
intron-intronENST00000508084ENST00000517973INPP4Bchr4

142963356

+GPX3chr5

150406475

+

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FusionProtFeatures for INPP4B_GPX3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INPP4B

O15327

GPX3

P22352

Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Protects cells and enzymes from oxidative damage, bycatalyzing the reduction of hydrogen peroxide, lipid peroxides andorganic hydroperoxide, by glutathione.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for INPP4B_GPX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INPP4B_GPX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INPP4B_GPX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGPX3P22352DB00143GlutathioneGlutathione peroxidase 3small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for INPP4B_GPX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGPX3C0014175Endometriosis2CTD_human
TgeneGPX3C0024121Lung Neoplasms2CTD_human
TgeneGPX3C0028754Obesity2CTD_human
TgeneGPX3C0001418Adenocarcinoma1CTD_human
TgeneGPX3C0015624Fanconi Syndrome1CTD_human
TgeneGPX3C0021655Insulin Resistance1CTD_human
TgeneGPX3C0023903Liver neoplasms1CTD_human
TgeneGPX3C0033578Prostatic Neoplasms1CTD_human
TgeneGPX3C0524851Neurodegenerative Disorders1CTD_human