FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17494

FusionGeneSummary for INPP4A_MGAT4A

check button Fusion gene summary
Fusion gene informationFusion gene name: INPP4A_MGAT4A
Fusion gene ID: 17494
HgeneTgene
Gene symbol

INPP4A

MGAT4A

Gene ID

3631

11320

Gene nameinositol polyphosphate-4-phosphatase type I Amannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
SynonymsINPP4|TVAS1GNT-IV|GNT-IVA|GnT-4a
Cytomap

2q11.2

2q11.2

Type of geneprotein-codingprotein-coding
Descriptiontype I inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate-4-phosphatase, type I, 107kDinositol polyphosphate-4-phosphatase, type I, 107kDaalpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase AN-acetylglucosaminyltransferase IVaN-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVaUDP-GlcNAc:a-1,3-D-mannoside b-1,4-acetylglucosaminyltransferase IVUD
Modification date2018052320180522
UniProtAcc

Q96PE3

Q9UM21

Ensembl transtripts involved in fusion geneENST00000409016, ENST00000409851, 
ENST00000409463, ENST00000074304, 
ENST00000545415, ENST00000409540, 
ENST00000523221, ENST00000467042, 
ENST00000264968, ENST00000393487, 
ENST00000414521, ENST00000409391, 
ENST00000461884, ENST00000495056, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: INPP4A [Title/Abstract] AND MGAT4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FD-A3SR-01AINPP4Achr2

99149958

+MGAT4Achr2

99242298

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000409016ENST00000264968INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000409016ENST00000393487INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000409016ENST00000414521INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000409016ENST00000409391INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000409016ENST00000461884INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000409016ENST00000495056INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000409851ENST00000264968INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000409851ENST00000393487INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000409851ENST00000414521INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000409851ENST00000409391INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000409851ENST00000461884INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000409851ENST00000495056INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-3CDSENST00000409463ENST00000264968INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-3CDSENST00000409463ENST00000393487INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-3CDSENST00000409463ENST00000414521INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-3CDSENST00000409463ENST00000409391INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-intronENST00000409463ENST00000461884INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-intronENST00000409463ENST00000495056INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000074304ENST00000264968INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000074304ENST00000393487INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000074304ENST00000414521INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000074304ENST00000409391INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000074304ENST00000461884INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000074304ENST00000495056INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000545415ENST00000264968INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000545415ENST00000393487INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000545415ENST00000414521INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000545415ENST00000409391INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000545415ENST00000461884INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000545415ENST00000495056INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000409540ENST00000264968INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000409540ENST00000393487INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000409540ENST00000414521INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000409540ENST00000409391INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000409540ENST00000461884INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000409540ENST00000495056INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000523221ENST00000264968INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000523221ENST00000393487INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000523221ENST00000414521INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
Frame-shiftENST00000523221ENST00000409391INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000523221ENST00000461884INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
5CDS-intronENST00000523221ENST00000495056INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-3CDSENST00000467042ENST00000264968INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-3CDSENST00000467042ENST00000393487INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-3CDSENST00000467042ENST00000414521INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-3CDSENST00000467042ENST00000409391INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-intronENST00000467042ENST00000461884INPP4Achr2

99149958

+MGAT4Achr2

99242298

-
intron-intronENST00000467042ENST00000495056INPP4Achr2

99149958

+MGAT4Achr2

99242298

-

Top

FusionProtFeatures for INPP4A_MGAT4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INPP4A

Q96PE3

MGAT4A

Q9UM21

Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate. Glycosyltransferase that participates in the transfer ofN-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structureof N-linked glycans. Essential for the production of tri- andtetra-antennary N-linked sugar chains. Involved in glucosetransport by mediating SLC2A2/GLUT2 glycosylation, therebycontrolling cell-surface expression of SLC2A2 in pancreatic betacells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for INPP4A_MGAT4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for INPP4A_MGAT4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INPP4ASMAD1, CD81, HERC2, NTRK1, NXT2, WDYHV1MGAT4ACCDC53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for INPP4A_MGAT4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for INPP4A_MGAT4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneINPP4AC3714756Intellectual Disability1CTD_human