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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1748

FusionGeneSummary for ANKMY1_GPR35

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKMY1_GPR35
Fusion gene ID: 1748
HgeneTgene
Gene symbol

ANKMY1

GPR35

Gene ID

51281

2859

Gene nameankyrin repeat and MYND domain containing 1G protein-coupled receptor 35
SynonymsZMYND13-
Cytomap

2q37.3

2q37.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat and MYND domain-containing protein 1testis-specific ankyrin-like protein 1zinc finger MYND domain-containing protein 13G-protein coupled receptor 35KYNA receptorkynurenic acid receptor
Modification date2018040320180523
UniProtAcc

Q9P2S6

Q9HC97

Ensembl transtripts involved in fusion geneENST00000373318, ENST00000391987, 
ENST00000373320, ENST00000406958, 
ENST00000272972, ENST00000361678, 
ENST00000403283, ENST00000401804, 
ENST00000536462, ENST00000405523, 
ENST00000405002, ENST00000462004, 
ENST00000319838, ENST00000438013, 
ENST00000403859, ENST00000407714, 
ENST00000430267, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 1 X 1=1
# samples 31
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: ANKMY1 [Title/Abstract] AND GPR35 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGPR35

GO:0007186

G-protein coupled receptor signaling pathway

16754668

TgeneGPR35

GO:0070098

chemokine-mediated signaling pathway

25411203


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPAADTCGA-2J-AABR-01AANKMY1chr2

241492331

-GPR35chr2

241569366

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000373318ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000373318ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000373318ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000373318ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000373318ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000391987ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000391987ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000391987ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000391987ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000391987ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000373320ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000373320ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000373320ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000373320ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000373320ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000406958ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000406958ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000406958ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000406958ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000406958ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000272972ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000272972ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000272972ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000272972ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000272972ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000361678ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000361678ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000361678ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000361678ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000361678ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000403283ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000403283ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000403283ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000403283ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000403283ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000401804ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000401804ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000401804ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000401804ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000401804ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000536462ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000536462ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000536462ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000536462ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000536462ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000405523ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000405523ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000405523ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000405523ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000405523ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000405002ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000405002ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000405002ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000405002ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5CDS-5UTRENST00000405002ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5UTR-5UTRENST00000462004ENST00000319838ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5UTR-5UTRENST00000462004ENST00000438013ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5UTR-5UTRENST00000462004ENST00000403859ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5UTR-5UTRENST00000462004ENST00000407714ANKMY1chr2

241492331

-GPR35chr2

241569366

+
5UTR-5UTRENST00000462004ENST00000430267ANKMY1chr2

241492331

-GPR35chr2

241569366

+

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FusionProtFeatures for ANKMY1_GPR35


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKMY1

Q9P2S6

GPR35

Q9HC97

Acts as a receptor for kynurenic acid, an intermediatein the tryptophan metabolic pathway. The activity of this receptoris mediated by G-proteins that elicit calcium mobilization andinositol phosphate production through G(qi/o) proteins.{ECO:0000269|PubMed:16754668}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKMY1_GPR35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKMY1_GPR35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANKMY1GPR35POTEE, YES1, KTI12, GNAO1, LGALS3, ATPIF1, ATP5B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ANKMY1_GPR35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGPR35Q9HC97DB11156PyrantelG-protein coupled receptor 35small moleculeapproved|vet_approved

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RelatedDiseases for ANKMY1_GPR35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource