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Fusion gene ID: 17471 |
FusionGeneSummary for INCENP_ANKFN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: INCENP_ANKFN1 | Fusion gene ID: 17471 | Hgene | Tgene | Gene symbol | INCENP | ANKFN1 | Gene ID | 3619 | 162282 |
| Gene name | inner centromere protein | ankyrin repeat and fibronectin type III domain containing 1 | |
| Synonyms | - | - | |
| Cytomap | 11q12.3 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inner centromere proteinbinds and activates aurora-B and -C in vivo and in vitrochromosomal passenger proteininner centromere protein INCENPinner centromere protein antigens 135/155kDa | ankyrin repeat and fibronectin type-III domain-containing protein 1 | |
| Modification date | 20180522 | 20180329 | |
| UniProtAcc | Q9NQS7 | Q8N957 | |
| Ensembl transtripts involved in fusion gene | ENST00000394818, ENST00000278849, ENST00000531099, | ENST00000318698, ENST00000566473, ENST00000574292, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 13 X 10 X 4=520 |
| # samples | 2 | 13 | |
| ** MAII score | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/520*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: INCENP [Title/Abstract] AND ANKFN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A259-01A | INCENP | chr11 | 61920023 | + | ANKFN1 | chr17 | 54587834 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000394818 | ENST00000318698 | INCENP | chr11 | 61920023 | + | ANKFN1 | chr17 | 54587834 | + |
| 3UTR-intron | ENST00000394818 | ENST00000566473 | INCENP | chr11 | 61920023 | + | ANKFN1 | chr17 | 54587834 | + |
| 3UTR-intron | ENST00000394818 | ENST00000574292 | INCENP | chr11 | 61920023 | + | ANKFN1 | chr17 | 54587834 | + |
| 3UTR-intron | ENST00000278849 | ENST00000318698 | INCENP | chr11 | 61920023 | + | ANKFN1 | chr17 | 54587834 | + |
| 3UTR-intron | ENST00000278849 | ENST00000566473 | INCENP | chr11 | 61920023 | + | ANKFN1 | chr17 | 54587834 | + |
| 3UTR-intron | ENST00000278849 | ENST00000574292 | INCENP | chr11 | 61920023 | + | ANKFN1 | chr17 | 54587834 | + |
| 3UTR-intron | ENST00000531099 | ENST00000318698 | INCENP | chr11 | 61920023 | + | ANKFN1 | chr17 | 54587834 | + |
| 3UTR-intron | ENST00000531099 | ENST00000566473 | INCENP | chr11 | 61920023 | + | ANKFN1 | chr17 | 54587834 | + |
| 3UTR-intron | ENST00000531099 | ENST00000574292 | INCENP | chr11 | 61920023 | + | ANKFN1 | chr17 | 54587834 | + |
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FusionProtFeatures for INCENP_ANKFN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| INCENP | ANKFN1 |
| Component of the chromosomal passenger complex (CPC), acomplex that acts as a key regulator of mitosis. The CPC complexhas essential functions at the centromere in ensuring correctchromosome alignment and segregation and is required forchromatin-induced microtubule stabilization and spindle assembly.Acts as a scaffold regulating CPC localization and activity. TheC-terminus associates with AURKB or AURKC, the N-terminusassociated with BIRC5/survivin and CDCA8/borealin tethers the CPCto the inner centromere, and the microtubule binding activitywithin the central SAH domain directs AURKB/C toward substratesnear microtubules (PubMed:15316025, PubMed:12925766,PubMed:27332895). The flexibility of the SAH domain is proposed toallow AURKB/C to follow substrates on dynamic microtubules whileensuring CPC docking to static chromatin (By similarity).Activates AURKB and AURKC (PubMed:27332895). Required forlocalization of CBX5 to mitotic centromeres (PubMed:21346195).Controls the kinetochore localization of BUB1 (PubMed:16760428).{ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766,ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428,ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for INCENP_ANKFN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for INCENP_ANKFN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| INCENP | CDCA8, AURKB, H2AFZ, BIRC5, SGOL1, AURKA, EVI5, SIRT7, HIST2H3C, CBX5, AURKC, HECW2, FLOT1, IFI16, HIST1H2BG, HIST1H3A, EWSR1, PHF8, EGFR, TRIM25 | ANKFN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for INCENP_ANKFN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for INCENP_ANKFN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | INCENP | C0025202 | melanoma | 1 | CTD_human |
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