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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17469

FusionGeneSummary for INADL_ST6GALNAC5

check button Fusion gene summary
Fusion gene informationFusion gene name: INADL_ST6GALNAC5
Fusion gene ID: 17469
HgeneTgene
Gene symbol

INADL

ST6GALNAC5

Gene ID

10207

81849

Gene namePATJ, crumbs cell polarity complex componentST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SynonymsCipp|INADL|InaD-like|hINADLSIAT7-E|SIAT7E|ST6GalNAcV
Cytomap

1p31.3

1p31.1

Type of geneprotein-codingprotein-coding
DescriptioninaD-like proteinPALS1-associated tight junction proteinPDZ domain proteinchannel-interacting PDZ domain proteininactivation no after-potential D-like proteininactivation-no-afterpotential D-likeprotein associated to tight junctionsalpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5GD1 alpha synthaseGalNAc alpha-2,6-sialyltransferase VST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5ST6 GalNAc alpha-2,6-sialyltr
Modification date2018052220180523
UniProtAcc

Q9BVH7

Ensembl transtripts involved in fusion geneENST00000316485, ENST00000371158, 
ENST00000543708, ENST00000545929, 
ENST00000472512, 
ENST00000477717, 
ENST00000496845, 
Fusion gene scores* DoF score8 X 6 X 7=3364 X 4 X 3=48
# samples 94
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: INADL [Title/Abstract] AND ST6GALNAC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-EW-A3U0-01AINADLchr1

62208227

+ST6GALNAC5chr1

77528660

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000316485ENST00000477717INADLchr1

62208227

+ST6GALNAC5chr1

77528660

+
5UTR-intronENST00000316485ENST00000496845INADLchr1

62208227

+ST6GALNAC5chr1

77528660

+
5UTR-3CDSENST00000371158ENST00000477717INADLchr1

62208227

+ST6GALNAC5chr1

77528660

+
5UTR-intronENST00000371158ENST00000496845INADLchr1

62208227

+ST6GALNAC5chr1

77528660

+
intron-3CDSENST00000543708ENST00000477717INADLchr1

62208227

+ST6GALNAC5chr1

77528660

+
intron-intronENST00000543708ENST00000496845INADLchr1

62208227

+ST6GALNAC5chr1

77528660

+
intron-3CDSENST00000545929ENST00000477717INADLchr1

62208227

+ST6GALNAC5chr1

77528660

+
intron-intronENST00000545929ENST00000496845INADLchr1

62208227

+ST6GALNAC5chr1

77528660

+
intron-3CDSENST00000472512ENST00000477717INADLchr1

62208227

+ST6GALNAC5chr1

77528660

+
intron-intronENST00000472512ENST00000496845INADLchr1

62208227

+ST6GALNAC5chr1

77528660

+

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FusionProtFeatures for INADL_ST6GALNAC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INADL

ST6GALNAC5

Q9BVH7

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Involved in the biosynthesis of ganglioside GD1a fromGM1b. It exhibits higher activity with glycolipids than withglycoproteins (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for INADL_ST6GALNAC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INADL_ST6GALNAC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INADLTJP3, CLDN1, MPP5, ARHGAP17, AMOT, PARD3, BAI1, AMOTL2, LATS1, LATS2, SAV1, YAP1, TP53RK, RNF166, LIN7C, LIN7A, GBA, GJB2, HSF2, SNCA, SLC33A1, RNASEH2A, RAB32, ANAPC15, CEP170P1, CDH1, HOMER3, PCDHAC2, WWC1ST6GALNAC5FBP1, FBXO2, JMJD8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INADL_ST6GALNAC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for INADL_ST6GALNAC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneST6GALNAC5C0003873Rheumatoid Arthritis2CTD_human