FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17449

FusionGeneSummary for IMMT_IMMT

check button Fusion gene summary
Fusion gene informationFusion gene name: IMMT_IMMT
Fusion gene ID: 17449
HgeneTgene
Gene symbol

IMMT

IMMT

Gene ID

10989

10989

Gene nameinner membrane mitochondrial proteininner membrane mitochondrial protein
SynonymsHMP|MINOS2|Mic60|P87|P87/89|P89|PIG4|PIG52HMP|MINOS2|Mic60|P87|P87/89|P89|PIG4|PIG52
Cytomap

2p11.2|2

2p11.2|2

Type of geneprotein-codingprotein-coding
DescriptionMICOS complex subunit MIC60cell proliferation-inducing gene 4/52 proteincell proliferation-inducing protein 52heart muscle proteinmitochondrial inner membrane organizing system 2mitochondrial inner membrane proteinmitofilinmotor proteinproliferatiMICOS complex subunit MIC60cell proliferation-inducing gene 4/52 proteincell proliferation-inducing protein 52heart muscle proteinmitochondrial inner membrane organizing system 2mitochondrial inner membrane proteinmitofilinmotor proteinproliferati
Modification date2018052720180527
UniProtAcc

Q16891

Q16891

Ensembl transtripts involved in fusion geneENST00000254636, ENST00000449247, 
ENST00000410111, ENST00000442664, 
ENST00000409051, ENST00000490238, 
ENST00000254636, ENST00000449247, 
ENST00000410111, ENST00000442664, 
ENST00000409051, ENST00000490238, 
Fusion gene scores* DoF score4 X 6 X 2=489 X 9 X 6=486
# samples 711
** MAII scorelog2(7/48*10)=0.54432051622381
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/486*10)=-2.14345279008112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IMMT [Title/Abstract] AND IMMT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU685307IMMTchr2

86371423

+IMMTchr2

86371866

-
ChiTaRS3.1BE159547IMMTchr2

86406595

-IMMTchr2

86400834

+
ChiTaRS3.1BU675384IMMTchr2

86371301

+IMMTchr2

86371519

-
ChiTaRS3.1CB854254IMMTchr2

86371423

+IMMTchr2

86371866

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000254636ENST00000254636IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000254636ENST00000449247IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000254636ENST00000410111IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000254636ENST00000442664IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000254636ENST00000409051IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-intronENST00000254636ENST00000490238IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000449247ENST00000254636IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000449247ENST00000449247IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000449247ENST00000410111IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000449247ENST00000442664IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000449247ENST00000409051IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-intronENST00000449247ENST00000490238IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000410111ENST00000254636IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000410111ENST00000449247IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000410111ENST00000410111IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000410111ENST00000442664IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000410111ENST00000409051IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-intronENST00000410111ENST00000490238IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000442664ENST00000254636IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000442664ENST00000449247IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000442664ENST00000410111IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000442664ENST00000442664IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000442664ENST00000409051IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-intronENST00000442664ENST00000490238IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000409051ENST00000254636IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000409051ENST00000449247IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000409051ENST00000410111IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000409051ENST00000442664IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000409051ENST00000409051IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-intronENST00000409051ENST00000490238IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000490238ENST00000254636IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000490238ENST00000449247IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000490238ENST00000410111IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000490238ENST00000442664IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000490238ENST00000409051IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-intronENST00000490238ENST00000490238IMMTchr2

86371423

+IMMTchr2

86371866

-
intron-3CDSENST00000254636ENST00000254636IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000254636ENST00000449247IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000254636ENST00000410111IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000254636ENST00000442664IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000254636ENST00000409051IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-intronENST00000254636ENST00000490238IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000449247ENST00000254636IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000449247ENST00000449247IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000449247ENST00000410111IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000449247ENST00000442664IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000449247ENST00000409051IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-intronENST00000449247ENST00000490238IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000410111ENST00000254636IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000410111ENST00000449247IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000410111ENST00000410111IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000410111ENST00000442664IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000410111ENST00000409051IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-intronENST00000410111ENST00000490238IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000442664ENST00000254636IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000442664ENST00000449247IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000442664ENST00000410111IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000442664ENST00000442664IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000442664ENST00000409051IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-intronENST00000442664ENST00000490238IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000409051ENST00000254636IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000409051ENST00000449247IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000409051ENST00000410111IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000409051ENST00000442664IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000409051ENST00000409051IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-intronENST00000409051ENST00000490238IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000490238ENST00000254636IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000490238ENST00000449247IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000490238ENST00000410111IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000490238ENST00000442664IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000490238ENST00000409051IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-intronENST00000490238ENST00000490238IMMTchr2

86406595

-IMMTchr2

86400834

+
intron-3CDSENST00000254636ENST00000254636IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000254636ENST00000449247IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000254636ENST00000410111IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000254636ENST00000442664IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000254636ENST00000409051IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-intronENST00000254636ENST00000490238IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000449247ENST00000254636IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000449247ENST00000449247IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000449247ENST00000410111IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000449247ENST00000442664IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000449247ENST00000409051IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-intronENST00000449247ENST00000490238IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000410111ENST00000254636IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000410111ENST00000449247IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000410111ENST00000410111IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000410111ENST00000442664IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000410111ENST00000409051IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-intronENST00000410111ENST00000490238IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000442664ENST00000254636IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000442664ENST00000449247IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000442664ENST00000410111IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000442664ENST00000442664IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000442664ENST00000409051IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-intronENST00000442664ENST00000490238IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000409051ENST00000254636IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000409051ENST00000449247IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000409051ENST00000410111IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000409051ENST00000442664IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000409051ENST00000409051IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-intronENST00000409051ENST00000490238IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000490238ENST00000254636IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000490238ENST00000449247IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000490238ENST00000410111IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000490238ENST00000442664IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-3CDSENST00000490238ENST00000409051IMMTchr2

86371301

+IMMTchr2

86371519

-
intron-intronENST00000490238ENST00000490238IMMTchr2

86371301

+IMMTchr2

86371519

-

Top

FusionProtFeatures for IMMT_IMMT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IMMT

Q16891

IMMT

Q16891


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for IMMT_IMMT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for IMMT_IMMT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for IMMT_IMMT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for IMMT_IMMT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIMMTC0029408Degenerative polyarthritis1CTD_human
TgeneIMMTC0029408Degenerative polyarthritis1CTD_human