FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17426

FusionGeneSummary for ILF3_MAPK13

check button Fusion gene summary
Fusion gene informationFusion gene name: ILF3_MAPK13
Fusion gene ID: 17426
HgeneTgene
Gene symbol

ILF3

MAPK13

Gene ID

3609

5603

Gene nameinterleukin enhancer binding factor 3mitogen-activated protein kinase 13
SynonymsCBTF|DRBF|DRBP76|MMP4|MPHOSPH4|MPP4|NF-AT-90|NF110|NF110b|NF90|NF90a|NF90b|NFAR|NFAR-1|NFAR2|TCP110|TCP80MAPK 13|MAPK-13|PRKM13|SAPK4|p38delta
Cytomap

19p13.2

6p21.31

Type of geneprotein-codingprotein-coding
Descriptioninterleukin enhancer-binding factor 3M-phase phosphoprotein 4double-stranded RNA-binding protein, 76 kDdsRNA binding protein NFAR-2/MPP4interleukin enhancer binding factor 3, 90kDinterleukin enhancer binding factor 3, 90kDanuclear factor associated mitogen-activated protein kinase 13MAP kinase 13MAP kinase p38 deltamitogen-activated protein kinase p38 deltastress-activated protein kinase 4
Modification date2018052320180523
UniProtAcc

Q12906

O15264

Ensembl transtripts involved in fusion geneENST00000420083, ENST00000449870, 
ENST00000318511, ENST00000407004, 
ENST00000589998, ENST00000250241, 
ENST00000592763, ENST00000588657, 
ENST00000590261, ENST00000586544, 
ENST00000211287, ENST00000373761, 
ENST00000373766, ENST00000373759, 
ENST00000490334, 
Fusion gene scores* DoF score16 X 9 X 10=14401 X 1 X 1=1
# samples 181
** MAII scorelog2(18/1440*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ILF3 [Title/Abstract] AND MAPK13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneILF3

GO:0006468

protein phosphorylation

21123651

HgeneILF3

GO:0045892

negative regulation of transcription, DNA-templated

11739746

HgeneILF3

GO:0045893

positive regulation of transcription, DNA-templated

11739746

TgeneMAPK13

GO:0006970

response to osmotic stress

9731215

TgeneMAPK13

GO:0018105

peptidyl-serine phosphorylation

15850461

TgeneMAPK13

GO:0034644

cellular response to UV

9218798

TgeneMAPK13

GO:0051403

stress-activated MAPK cascade

9218798

TgeneMAPK13

GO:0070301

cellular response to hydrogen peroxide

9218798

TgeneMAPK13

GO:0071347

cellular response to interleukin-1

9218798

TgeneMAPK13

GO:0072709

cellular response to sorbitol

9218798

TgeneMAPK13

GO:0072740

cellular response to anisomycin

9218798

TgeneMAPK13

GO:1903936

cellular response to sodium arsenite

9218798


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-4Z-AA7M-01AILF3chr19

10765163

+MAPK13chr6

36099048

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000420083ENST00000211287ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000420083ENST00000373761ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000420083ENST00000373766ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-5UTRENST00000420083ENST00000373759ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3UTRENST00000420083ENST00000490334ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000449870ENST00000211287ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000449870ENST00000373761ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000449870ENST00000373766ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-5UTRENST00000449870ENST00000373759ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3UTRENST00000449870ENST00000490334ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000318511ENST00000211287ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000318511ENST00000373761ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000318511ENST00000373766ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-5UTRENST00000318511ENST00000373759ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3UTRENST00000318511ENST00000490334ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000407004ENST00000211287ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000407004ENST00000373761ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000407004ENST00000373766ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-5UTRENST00000407004ENST00000373759ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3UTRENST00000407004ENST00000490334ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000589998ENST00000211287ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000589998ENST00000373761ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3CDSENST00000589998ENST00000373766ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-5UTRENST00000589998ENST00000373759ILF3chr19

10765163

+MAPK13chr6

36099048

+
5UTR-3UTRENST00000589998ENST00000490334ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000250241ENST00000211287ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000250241ENST00000373761ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000250241ENST00000373766ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-5UTRENST00000250241ENST00000373759ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3UTRENST00000250241ENST00000490334ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000592763ENST00000211287ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000592763ENST00000373761ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000592763ENST00000373766ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-5UTRENST00000592763ENST00000373759ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3UTRENST00000592763ENST00000490334ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000588657ENST00000211287ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000588657ENST00000373761ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000588657ENST00000373766ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-5UTRENST00000588657ENST00000373759ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3UTRENST00000588657ENST00000490334ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000590261ENST00000211287ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000590261ENST00000373761ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000590261ENST00000373766ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-5UTRENST00000590261ENST00000373759ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3UTRENST00000590261ENST00000490334ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000586544ENST00000211287ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000586544ENST00000373761ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3CDSENST00000586544ENST00000373766ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-5UTRENST00000586544ENST00000373759ILF3chr19

10765163

+MAPK13chr6

36099048

+
intron-3UTRENST00000586544ENST00000490334ILF3chr19

10765163

+MAPK13chr6

36099048

+

Top

FusionProtFeatures for ILF3_MAPK13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ILF3

Q12906

MAPK13

O15264

Serine/threonine kinase which acts as an essentialcomponent of the MAP kinase signal transduction pathway. MAPK13 isone of the four p38 MAPKs which play an important role in thecascades of cellular responses evoked by extracellular stimulisuch as proinflammatory cytokines or physical stress leading todirect activation of transcription factors such as ELK1 and ATF2.Accordingly, p38 MAPKs phosphorylate a broad range of proteins andit has been estimated that they may have approximately 200 to 300substrates each. MAPK13 is one of the less studied p38 MAPKisoforms. Some of the targets are downstream kinases such asMAPKAPK2, which are activated through phosphorylation and furtherphosphorylate additional targets. Plays a role in the regulationof protein translation by phosphorylating and inactivating EEF2K.Involved in cytoskeletal remodeling through phosphorylation ofMAPT and STMN1. Mediates UV irradiation induced up-regulation ofthe gene expression of CXCL14. Plays an important role in theregulation of epidermal keratinocyte differentiation, apoptosisand skin tumor development. Phosphorylates the transcriptionalactivator MYB in response to stress which leads to rapid MYBdegradation via a proteasome-dependent pathway. MAPK13 alsophosphorylates and down-regulates PRKD1 during regulation ofinsulin secretion in pancreatic beta cells.{ECO:0000269|PubMed:11500363, ECO:0000269|PubMed:11943212,ECO:0000269|PubMed:15632108, ECO:0000269|PubMed:17256148,ECO:0000269|PubMed:18006338, ECO:0000269|PubMed:18367666,ECO:0000269|PubMed:20478268, ECO:0000269|PubMed:9731215}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ILF3_MAPK13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ILF3_MAPK13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ILF3MAGEA11, TRIP6, KRTAP4-12, MDFI, PLSCR1, PRMT1, GDF9, ILF2, EIF2AK2, FUS, PRKDC, XPO5, RRP1B, HNRNPA1, MEPCE, RPAP1, KHDRBS2, YY1, TADA2A, DGCR8, HDAC5, NOP56, STAU1, ZNF346, NR5A2, SMARCAD1, NDRG1, XRCC6, SF3A2, ARRB2, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, LNX1, BIRC2, RAE1, GRK5, DHX9, RPL14, RPS13, RPL13, RPL4, RPL8, RPL19, RPL17, RPL29, RPL21, RPL18, RPL6, RPL11, RPS2, RPS3A, RPS15A, RPL37A, NCL, RPL23, RPL7A, RPL24, RPL7, RPS6, RPL23A, RPL12, RPL15, RPL18A, HNRNPK, RPS26, SF3B1, RPS3, SYNCRIP, MOV10, RPS4X, PABPC1, RPL31, RPS24, RPL27, RPL3, RPS16, RPS8, RPL10A, RPS23, RPL32, RPL5, LMNB1, RPL22, RPS17, HNRNPR, RPS14, RPL9, HSPA5, SRSF5, SRSF3, SART1, RPS28, RNPS1, SF3B5, SF3B6, SNRNP70, SF3B4, TRA2B, RPS25, LSM2, SRRM2, RPS20, RBM39, POLR2A, SFPQ, PHB2, ZNF326, DHX30, PTRF, SON, MRPL41, LETM1, SERINC1, EMC1, RTN4, MRPS14, MRPL42, RCN1, MRPL44, KRT17, QSOX2, MRPL45, MRPL15, OPA1, SSR4, PPT2, PC, RPS27L, MRPL40, SARS2, MRPL4, PTPN1, STOM, PRKCDBP, PGRMC1, TUBA4A, MRPL11, MRPL23, LAMP1, RPN2, NFXL1, RAB31, MYO1C, RAP1A, JUP, IARS2, CHCHD4, MRPL39, UQCRH, RRBP1, MRPS27, NUPL1, MRPS35, PLP2, MRPS5, MRPS9, MRPL1, MRPS10, RPN1, SLIRP, MRPL9, PTBP3, NDUFA2, VTN, UQCRC1, VAMP2, MRPL10, MRPL32, PTCD1, PTDSS2, PPAP2A, SSR1, NUP35, OCIAD2, MYO1E, MRPL20, PDIA4, MRPL12, NOMO1, SLC25A17, PRPH, SNCG, NDUFS6, ALDH18A1, NDUFV1, GAA, RAB2A, TMPO, MYH10, RMDN3, SSBP1, LRRC59, LMO7, PICALM, RPLP0P6, NCLN, RAB14, TPM4, RAB11A, SENP3, MFF, MRPL38, TXN2, SLC12A4, TRIM56, RCN2, RALA, MRPL55, NUCKS1, LPCAT1, DHODH, NDUFB9, LRPPRC, LAMTOR2, NDUFV3, SFXN1, MRPL17, TOMM22, SPCS2, PYROXD1, NXF1, HNRNPC, EIF2A, MAGOH, EIF4A3, FN1, VCAM1, SNRPC, SF1, RBM5, XAB2, ZNF830, HNRNPH2, RNF113A, IFIT2, IFIT3, IL7R, UBL4A, ITGA4, UNC45B, SCARNA22, SNORD88C, SNORD95, RMRP, SNORA34, SNORD50A, SNORD50B, RNU5A-1, KIAA0825, KIF5C, SNORD3C, PCBD2, SNORA57, SNORD19, SNORD10, ELOVL7, SNORD1C, IGKC, HIST1H1E, RPL10, RNU5B-1, HIST2H2BE, ACTG1, SNORD116-18, SNORD116-1, SNORD116-24, MALAT1, HIST1H2AM, HSP90AA1, EEF1A1, SNORA71D, SNORD116-22, RNU2-4P, SNORD116-29, CBX8, IGSF8, ICAM1, CSF2, FBXO6, TARDBP, HNRNPL, VEGFA, VHL, RPA3, RPA2, RPA1, ERG, LGR4, IVNS1ABP, MDM2, AURKA, HUWE1, FBXW11, RBPMS, CUL7, OBSL1, CCDC8, EZH2, SUZ12, EED, RNF2, BMI1, ABL1, ILK, SGK2, SRPK1, TNK1, ESR1, RAD50, MCM5, EP300, NTRK1, DHX16, LSM3, HIST1H3E, HNRNPU, PPP1CB, PPP1CC, SNCA, MATR3, MPHOSPH8, CRY1, MCM2, CDC5L, MEX3C, U2AF2, EGFR, ZNF746, RBM3, EIF2AK3, UBC, CYLD, TRIM25, BRCA1, LMNA, MTF1MAPK13MAPK8IP2, ATF2, FGF12, AKIP1, ANKLE2, MBP, HTRA2, APP, VCP, SMAD4, MAPT, GPX4, POTEF, MAPK12, MAP3K4, MAPKAPK3, SQSTM1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ILF3_MAPK13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ILF3_MAPK13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAPK13C0008370Cholestasis1CTD_human