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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1739

FusionGeneSummary for ANKIB1_TNFRSF17

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKIB1_TNFRSF17
Fusion gene ID: 1739
HgeneTgene
Gene symbol

ANKIB1

TNFRSF17

Gene ID

54467

608

Gene nameankyrin repeat and IBR domain containing 1TNF receptor superfamily member 17
Synonyms-BCM|BCMA|CD269|TNFRSF13A
Cytomap

7q21.2

16p13.13

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat and IBR domain-containing protein 1tumor necrosis factor receptor superfamily member 17B cell maturation antigenB-cell maturation factorB-cell maturation protein
Modification date2018052320180519
UniProtAcc

Q9P2G1

Q02223

Ensembl transtripts involved in fusion geneENST00000265742, ENST00000486698, 
ENST00000053243, ENST00000396495, 
Fusion gene scores* DoF score9 X 6 X 7=3783 X 2 X 4=24
# samples 94
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANKIB1 [Title/Abstract] AND TNFRSF17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-RD-A8MW-01AANKIB1chr7

91875833

+TNFRSF17chr16

12060052

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000265742ENST00000053243ANKIB1chr7

91875833

+TNFRSF17chr16

12060052

+
5UTR-intronENST00000265742ENST00000396495ANKIB1chr7

91875833

+TNFRSF17chr16

12060052

+
intron-3CDSENST00000486698ENST00000053243ANKIB1chr7

91875833

+TNFRSF17chr16

12060052

+
intron-intronENST00000486698ENST00000396495ANKIB1chr7

91875833

+TNFRSF17chr16

12060052

+

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FusionProtFeatures for ANKIB1_TNFRSF17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKIB1

Q9P2G1

TNFRSF17

Q02223

Might act as an E3 ubiquitin-protein ligase, or as partof E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.{ECO:0000250}. Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL.Promotes B-cell survival and plays a role in the regulation ofhumoral immunity. Activates NF-kappa-B and JNK.{ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733,ECO:0000269|PubMed:10973284}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKIB1_TNFRSF17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKIB1_TNFRSF17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANKIB1UBC, KPNA2, NR4A1, CEP250TNFRSF17TNFSF13B, TRAF1, TRAF2, TRAF3, TRAF5, TRAF6, FAM105A, FAM171A1, OPA3, CD70, PARK2, TARBP1, ZMPSTE24, TSPAN6, INTS7, AGPAT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKIB1_TNFRSF17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKIB1_TNFRSF17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource