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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17380

FusionGeneSummary for IL20RA_CPM

check button Fusion gene summary
Fusion gene informationFusion gene name: IL20RA_CPM
Fusion gene ID: 17380
HgeneTgene
Gene symbol

IL20RA

CPM

Gene ID

53832

1368

Gene nameinterleukin 20 receptor subunit alphacarboxypeptidase M
SynonymsCRF2-8|IL-20R-alpha|IL-20R1|IL-20RA-
Cytomap

6q23.3

12q15

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-20 receptor subunit alphaclass II cytokine receptor ZCYTOR7cytokine receptor family 2 member 8interleukin 20 receptor alpha subunitinterleukin 20 receptor, alphainterleukin-20 receptor Icarboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B
Modification date2018052320180523
UniProtAcc

Q9UHF4

P14384

Ensembl transtripts involved in fusion geneENST00000316649, ENST00000367748, 
ENST00000541547, ENST00000468393, 
ENST00000367746, 
ENST00000546373, 
ENST00000551568, ENST00000338356, 
ENST00000549691, 
Fusion gene scores* DoF score2 X 2 X 2=838 X 10 X 8=3040
# samples 335
** MAII scorelog2(3/8*10)=1.90689059560852log2(35/3040*10)=-3.11864449649862
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IL20RA [Title/Abstract] AND CPM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-HB-A3YV-01AIL20RAchr6

137365229

-CPMchr12

69279669

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000316649ENST00000546373IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-3CDSENST00000316649ENST00000551568IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-3CDSENST00000316649ENST00000338356IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-intronENST00000316649ENST00000549691IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-3CDSENST00000367748ENST00000546373IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-3CDSENST00000367748ENST00000551568IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-3CDSENST00000367748ENST00000338356IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-intronENST00000367748ENST00000549691IL20RAchr6

137365229

-CPMchr12

69279669

-
5UTR-3CDSENST00000541547ENST00000546373IL20RAchr6

137365229

-CPMchr12

69279669

-
5UTR-3CDSENST00000541547ENST00000551568IL20RAchr6

137365229

-CPMchr12

69279669

-
5UTR-3CDSENST00000541547ENST00000338356IL20RAchr6

137365229

-CPMchr12

69279669

-
5UTR-intronENST00000541547ENST00000549691IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-3CDSENST00000468393ENST00000546373IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-3CDSENST00000468393ENST00000551568IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-3CDSENST00000468393ENST00000338356IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-intronENST00000468393ENST00000549691IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-3CDSENST00000367746ENST00000546373IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-3CDSENST00000367746ENST00000551568IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-3CDSENST00000367746ENST00000338356IL20RAchr6

137365229

-CPMchr12

69279669

-
intron-intronENST00000367746ENST00000549691IL20RAchr6

137365229

-CPMchr12

69279669

-

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FusionProtFeatures for IL20RA_CPM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL20RA

Q9UHF4

CPM

P14384

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 andIL24. The IL20RA/IL10RB dimer is a receptor for IL26. Specifically removes C-terminal basic residues (Arg orLys) from peptides and proteins. It is believed to play importantroles in the control of peptide hormone and growth factor activityat the cell surface, and in the membrane-localized degradation ofextracellular proteins. {ECO:0000269|PubMed:12457462}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IL20RA_CPM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IL20RA_CPM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IL20RATNIK, UBB, NFRKB, LAPTM4B, DIRAS1, STAT3, PIK3CA, CYB5R1, CDC6, ROCK1, TAF7, THAP11, C2CD2L, ARF5, SNX17, BET1, HDLBP, RHEB, POP4, SLC30A1, CERK, AGBL5, PIK3CB, CCDC8, DIP2A, UPK3BL, STX5, PIK3R1, PTPRD, MYO5ACPMELAVL1, CAPZA2, DBN1, FLNA, GAK, MYH9, PPP1CC, RAB7A, PDLIM7, ATP6AP2, SYNPO, MAPRE1, GOLT1B, LIMA1, ANLN, MYO19, ZSCAN12, ULBP1, FTH1, TBC1D22B, GTPBP3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IL20RA_CPM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IL20RA_CPM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIL20RAC0000786Spontaneous abortion1CTD_human
TgeneCPMC0014175Endometriosis1CTD_human
TgeneCPMC0037116Silicosis1CTD_human