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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17333

FusionGeneSummary for IKZF3_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: IKZF3_BCAS3
Fusion gene ID: 17333
HgeneTgene
Gene symbol

IKZF3

BCAS3

Gene ID

22806

54828

Gene nameIKAROS family zinc finger 3BCAS3, microtubule associated cell migration factor
SynonymsAIO|AIOLOS|ZNFN1A3GAOB1|MAAB
Cytomap

17q12-q21.1

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos)breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018052320180523
UniProtAcc

Q9UKT9

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000346872, ENST00000394189, 
ENST00000439167, ENST00000535189, 
ENST00000377944, ENST00000377945, 
ENST00000377952, ENST00000377958, 
ENST00000346243, ENST00000350532, 
ENST00000351680, ENST00000467757, 
ENST00000439016, ENST00000583368, 
ENST00000589222, ENST00000407086, 
ENST00000390652, ENST00000408905, 
ENST00000588462, ENST00000585744, 
ENST00000588874, ENST00000585812, 
Fusion gene scores* DoF score5 X 4 X 4=8026 X 15 X 15=5850
# samples 641
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IKZF3 [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A250-01AIKZF3chr17

37933904

-BCAS3chr17

58945937

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000346872ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000346872ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000346872ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000346872ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000346872ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000346872ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000346872ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000346872ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000394189ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000394189ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000394189ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000394189ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000394189ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000394189ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000394189ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000394189ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000439167ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000439167ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000439167ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000439167ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000439167ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000439167ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000439167ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000439167ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000535189ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000535189ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000535189ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000535189ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000535189ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000535189ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000535189ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000535189ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000377944ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000377944ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000377944ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000377944ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000377944ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000377944ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000377944ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000377944ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000377945ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000377945ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000377945ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000377945ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000377945ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000377945ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000377945ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000377945ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000377952ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000377952ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000377952ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000377952ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000377952ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000377952ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000377952ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000377952ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000377958ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000377958ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000377958ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000377958ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000377958ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000377958ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000377958ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000377958ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000346243ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000346243ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000346243ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000346243ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000346243ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000346243ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000346243ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000346243ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000350532ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000350532ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000350532ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000350532ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-3CDSENST00000350532ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000350532ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000350532ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
intron-intronENST00000350532ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000351680ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000351680ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000351680ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000351680ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000351680ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000351680ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000351680ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000351680ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000467757ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000467757ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000467757ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000467757ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000467757ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000467757ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000467757ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000467757ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000439016ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000439016ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000439016ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000439016ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000439016ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000439016ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000439016ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000439016ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000583368ENST00000589222IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000583368ENST00000407086IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000583368ENST00000390652IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000583368ENST00000408905IKZF3chr17

37933904

-BCAS3chr17

58945937

+
Frame-shitENST00000583368ENST00000588462IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000583368ENST00000585744IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000583368ENST00000588874IKZF3chr17

37933904

-BCAS3chr17

58945937

+
5CDS-intronENST00000583368ENST00000585812IKZF3chr17

37933904

-BCAS3chr17

58945937

+

Top

FusionProtFeatures for IKZF3_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IKZF3

Q9UKT9

BCAS3

Q9H6U6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for IKZF3_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IKZF3_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IKZF3UBE2I, SIN3A, SIN3B, HDAC2, HDAC4, HDAC5, HDAC7, CHD4, IKZF4, IKZF5, IKZF2, HRAS, BCL2L1, IKZF1, NOTCH1, FOXP3, CRBN, UBC, ARNT2, DGCR6, PRKAB2, AES, AQP1, RHOA, CDKN1A, CDKN2D, GEM, GRB2, HNRNPF, KRT19, LMO1, LMO2, PFDN5, PIK3R2, PIN1, PRKAA1, PSMA1, RAD51D, STK16, STX11, POLR1C, EMC2, FAM115A, AKAP9, BCAS2, KAT5, MRPL28, FARS2, NEK6, IKZF3, ABLIM3, PPP1R16B, POLM, OSGIN1, CHCHD2, SPG21, OAZ3, C1orf109, MAGOHB, FANCL, TBC1D22B, RCOR3, PCID2, CABP5, LGALS14, EXOSC5, STAMBPL1, TRAPPC6A, ARMC7, TSSK3, ING5, ZGPAT, FBF1, ATPAF2, EFHC1, MRPL53, EXOC8, TEKT4, TSTD2, NATD1, MORN3, TRIM42, ARMC8, SETMAR, DGCR14, GID4, MAD1L1, LDOC1, STK26, SUMO1, PRDM1, CUL4A, GATAD2B, TRIM25, SMARCB1BCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for IKZF3_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for IKZF3_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIKZF3C0003873Rheumatoid Arthritis1CTD_human
HgeneIKZF3C0004096Asthma1CTD_human
HgeneIKZF3C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human