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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17331

FusionGeneSummary for IKZF2_DOCK2

check button Fusion gene summary
Fusion gene informationFusion gene name: IKZF2_DOCK2
Fusion gene ID: 17331
HgeneTgene
Gene symbol

IKZF2

DOCK2

Gene ID

22807

1794

Gene nameIKAROS family zinc finger 2dedicator of cytokinesis 2
SynonymsANF1A2|HELIOS|ZNF1A2|ZNFN1A2IMD40
Cytomap

2q34

5q35.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein Heliosikaros family zinc finger protein 2zinc finger DNA binding protein Helioszinc finger protein, subfamily 1A, 2 (Helios)dedicator of cytokinesis protein 2dedicator of cyto-kinesis 2
Modification date2018052320180519
UniProtAcc

Q9UKS7

Q92608

Ensembl transtripts involved in fusion geneENST00000457361, ENST00000342002, 
ENST00000434687, ENST00000374319, 
ENST00000374327, ENST00000451136, 
ENST00000413091, ENST00000421754, 
ENST00000442445, 		ENST00000256935, 
ENST00000540750, ENST00000520908, 
ENST00000523351, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 7 X 6=378
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IKZF2 [Title/Abstract] AND DOCK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA440020IKZF2chr2

214012195

-DOCK2chr5

169435498

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000457361ENST00000256935IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000457361ENST00000540750IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000457361ENST00000520908IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3UTRENST00000457361ENST00000523351IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000342002ENST00000256935IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000342002ENST00000540750IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000342002ENST00000520908IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3UTRENST00000342002ENST00000523351IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000434687ENST00000256935IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000434687ENST00000540750IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000434687ENST00000520908IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3UTRENST00000434687ENST00000523351IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000374319ENST00000256935IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000374319ENST00000540750IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000374319ENST00000520908IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3UTRENST00000374319ENST00000523351IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000374327ENST00000256935IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000374327ENST00000540750IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000374327ENST00000520908IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3UTRENST00000374327ENST00000523351IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000451136ENST00000256935IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000451136ENST00000540750IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000451136ENST00000520908IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3UTRENST00000451136ENST00000523351IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000413091ENST00000256935IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000413091ENST00000540750IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000413091ENST00000520908IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3UTRENST00000413091ENST00000523351IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000421754ENST00000256935IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000421754ENST00000540750IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000421754ENST00000520908IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3UTRENST00000421754ENST00000523351IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000442445ENST00000256935IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000442445ENST00000540750IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3CDSENST00000442445ENST00000520908IKZF2chr2

214012195

-DOCK2chr5

169435498

+
intron-3UTRENST00000442445ENST00000523351IKZF2chr2

214012195

-DOCK2chr5

169435498

+

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FusionProtFeatures for IKZF2_DOCK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IKZF2

Q9UKS7

DOCK2

Q92608

Involved in cytoskeletal rearrangements required forlymphocyte migration in response of chemokines. Activates RAC1 andRAC2, but not CDC42, by functioning as a guanine nucleotideexchange factor (GEF), which exchanges bound GDP for free GTP. Mayalso participate in IL2 transcriptional activation via theactivation of RAC2. {ECO:0000269|PubMed:21613211}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IKZF2_DOCK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IKZF2_DOCK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IKZF2_DOCK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IKZF2_DOCK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIKZF2C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneIKZF2C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneDOCK2C0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneDOCK2C4225328IMMUNODEFICIENCY 401ORPHANET;UNIPROT