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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17327

FusionGeneSummary for IKZF1_IKZF1

check button Fusion gene summary
Fusion gene informationFusion gene name: IKZF1_IKZF1
Fusion gene ID: 17327
HgeneTgene
Gene symbol

IKZF1

IKZF1

Gene ID

10320

10320

Gene nameIKAROS family zinc finger 1IKAROS family zinc finger 1
SynonymsCVID13|Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1CVID13|Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1
Cytomap

7p12.2

7p12.2

Type of geneprotein-codingprotein-coding
DescriptionDNA-binding protein IkarosCLL-associated antigen KW-6ikaros family zinc finger protein 1lymphoid transcription factor LyF-1protein phosphatase 1, regulatory subunit 92zinc finger protein, subfamily 1A, 1 (Ikaros)DNA-binding protein IkarosCLL-associated antigen KW-6ikaros family zinc finger protein 1lymphoid transcription factor LyF-1protein phosphatase 1, regulatory subunit 92zinc finger protein, subfamily 1A, 1 (Ikaros)
Modification date2018052720180527
UniProtAcc

Q13422

Q13422

Ensembl transtripts involved in fusion geneENST00000440768, ENST00000359197, 
ENST00000343574, ENST00000331340, 
ENST00000349824, ENST00000357364, 
ENST00000346667, ENST00000438033, 
ENST00000439701, ENST00000413698, 
ENST00000492782, 
ENST00000440768, 
ENST00000359197, ENST00000343574, 
ENST00000331340, ENST00000349824, 
ENST00000357364, ENST00000346667, 
ENST00000438033, ENST00000439701, 
ENST00000413698, ENST00000492782, 
Fusion gene scores* DoF score5 X 4 X 3=606 X 6 X 3=108
# samples 66
** MAII scorelog2(6/60*10)=0log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IKZF1 [Title/Abstract] AND IKZF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI241390IKZF1chr7

50358643

-IKZF1chr7

50367353

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000440768ENST00000440768IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000440768ENST00000359197IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000440768ENST00000343574IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000440768ENST00000331340IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000440768ENST00000349824IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000440768ENST00000357364IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000440768ENST00000346667IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000440768ENST00000438033IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000440768ENST00000439701IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000440768ENST00000413698IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000440768ENST00000492782IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000359197ENST00000440768IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000359197ENST00000359197IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000359197ENST00000343574IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000359197ENST00000331340IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000359197ENST00000349824IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000359197ENST00000357364IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000359197ENST00000346667IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000359197ENST00000438033IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000359197ENST00000439701IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000359197ENST00000413698IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000359197ENST00000492782IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000343574ENST00000440768IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000343574ENST00000359197IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000343574ENST00000343574IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000343574ENST00000331340IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000343574ENST00000349824IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000343574ENST00000357364IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000343574ENST00000346667IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000343574ENST00000438033IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000343574ENST00000439701IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000343574ENST00000413698IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000343574ENST00000492782IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000331340ENST00000440768IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000331340ENST00000359197IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000331340ENST00000343574IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000331340ENST00000331340IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000331340ENST00000349824IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000331340ENST00000357364IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000331340ENST00000346667IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000331340ENST00000438033IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000331340ENST00000439701IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000331340ENST00000413698IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000331340ENST00000492782IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000349824ENST00000440768IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000349824ENST00000359197IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000349824ENST00000343574IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000349824ENST00000331340IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000349824ENST00000349824IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000349824ENST00000357364IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000349824ENST00000346667IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000349824ENST00000438033IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000349824ENST00000439701IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000349824ENST00000413698IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000349824ENST00000492782IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000357364ENST00000440768IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000357364ENST00000359197IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000357364ENST00000343574IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000357364ENST00000331340IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000357364ENST00000349824IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000357364ENST00000357364IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000357364ENST00000346667IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000357364ENST00000438033IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000357364ENST00000439701IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000357364ENST00000413698IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000357364ENST00000492782IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000346667ENST00000440768IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000346667ENST00000359197IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000346667ENST00000343574IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000346667ENST00000331340IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000346667ENST00000349824IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000346667ENST00000357364IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000346667ENST00000346667IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000346667ENST00000438033IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000346667ENST00000439701IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000346667ENST00000413698IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000346667ENST00000492782IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000438033ENST00000440768IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000438033ENST00000359197IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000438033ENST00000343574IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000438033ENST00000331340IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000438033ENST00000349824IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000438033ENST00000357364IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000438033ENST00000346667IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000438033ENST00000438033IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000438033ENST00000439701IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000438033ENST00000413698IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000438033ENST00000492782IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000439701ENST00000440768IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000439701ENST00000359197IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000439701ENST00000343574IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000439701ENST00000331340IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000439701ENST00000349824IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000439701ENST00000357364IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000439701ENST00000346667IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000439701ENST00000438033IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000439701ENST00000439701IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000439701ENST00000413698IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000439701ENST00000492782IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000413698ENST00000440768IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000413698ENST00000359197IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000413698ENST00000343574IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000413698ENST00000331340IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000413698ENST00000349824IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000413698ENST00000357364IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000413698ENST00000346667IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000413698ENST00000438033IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000413698ENST00000439701IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000413698ENST00000413698IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000413698ENST00000492782IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000492782ENST00000440768IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000492782ENST00000359197IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000492782ENST00000343574IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000492782ENST00000331340IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000492782ENST00000349824IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000492782ENST00000357364IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000492782ENST00000346667IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000492782ENST00000438033IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000492782ENST00000439701IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000492782ENST00000413698IKZF1chr7

50358643

-IKZF1chr7

50367353

-
intron-intronENST00000492782ENST00000492782IKZF1chr7

50358643

-IKZF1chr7

50367353

-

Top

FusionProtFeatures for IKZF1_IKZF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IKZF1

Q13422

IKZF1

Q13422

Transcription regulator of hematopoietic celldifferentiation (PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in thedevelopment of lymphocytes, B- and T-cells. Binds and activatesthe enhancer (delta-A element) of the CD3-delta gene. Repressor ofthe TDT (fikzfterminal deoxynucleotidyltransferase) gene duringthymocyte differentiation. Regulates transcription throughassociation with both HDAC-dependent and HDAC-independentcomplexes. Targets the 2 chromatin-remodeling complexes, NuRD andBAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis inadult erythroid cells. Confers early temporal competence toretinal progenitor cells (RPCs) (By similarity). Function isisoform-specific and is modulated by dominant-negative inactiveisoforms (PubMed:17135265, PubMed:17934067).{ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490,ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067,ECO:0000269|PubMed:19141594}. Transcription regulator of hematopoietic celldifferentiation (PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in thedevelopment of lymphocytes, B- and T-cells. Binds and activatesthe enhancer (delta-A element) of the CD3-delta gene. Repressor ofthe TDT (fikzfterminal deoxynucleotidyltransferase) gene duringthymocyte differentiation. Regulates transcription throughassociation with both HDAC-dependent and HDAC-independentcomplexes. Targets the 2 chromatin-remodeling complexes, NuRD andBAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis inadult erythroid cells. Confers early temporal competence toretinal progenitor cells (RPCs) (By similarity). Function isisoform-specific and is modulated by dominant-negative inactiveisoforms (PubMed:17135265, PubMed:17934067).{ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490,ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067,ECO:0000269|PubMed:19141594}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IKZF1_IKZF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IKZF1_IKZF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IKZF1_IKZF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IKZF1_IKZF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIKZF1C0009324Ulcerative Colitis1CTD_human
HgeneIKZF1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
HgeneIKZF1C0024141Lupus Erythematosus, Systemic1CTD_human
HgeneIKZF1C0024299Lymphoma1CTD_human
HgeneIKZF1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneIKZF1C4225173IMMUNODEFICIENCY, COMMON VARIABLE, 131ORPHANET;UNIPROT
TgeneIKZF1C0009324Ulcerative Colitis1CTD_human
TgeneIKZF1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneIKZF1C0024141Lupus Erythematosus, Systemic1CTD_human
TgeneIKZF1C0024299Lymphoma1CTD_human
TgeneIKZF1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneIKZF1C4225173IMMUNODEFICIENCY, COMMON VARIABLE, 131ORPHANET;UNIPROT