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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 17317

FusionGeneSummary for IKBKB_GOT1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: IKBKB_GOT1L1
Fusion gene ID: 17317
HgeneTgene
Gene symbol

IKBKB

GOT1L1

Gene ID

3551

137362

Gene nameinhibitor of nuclear factor kappa B kinase subunit betaglutamic-oxaloacetic transaminase 1 like 1
SynonymsIKK-beta|IKK2|IKKB|IMD15|NFKBIKB-
Cytomap

8p11.21

8p11.23

Type of geneprotein-codingprotein-coding
Descriptioninhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B kinase 2I-kappa-B-kinase betaIKK-Binhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betanuclear factor NF-kappa-B inhibitor kinase betaputative aspartate aminotransferase, cytoplasmic 2glutamate oxaloacetate transaminase 1-like protein 1transaminase A-like protein 1
Modification date2018052320180523
UniProtAcc

O14920

Q8NHS2

Ensembl transtripts involved in fusion geneENST00000520810, ENST00000416505, 
ENST00000519735, ENST00000520835, 
ENST00000379708, ENST00000518983, 
ENST00000522147, ENST00000522785, 
ENST00000307599, ENST00000518826, 
Fusion gene scores* DoF score8 X 6 X 6=2882 X 3 X 2=12
# samples 102
** MAII scorelog2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IKBKB [Title/Abstract] AND GOT1L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIKBKB

GO:0006468

protein phosphorylation

15084260|20434986

HgeneIKBKB

GO:0018105

peptidyl-serine phosphorylation

21399639

HgeneIKBKB

GO:0042325

regulation of phosphorylation

26212789

HgeneIKBKB

GO:0045944

positive regulation of transcription by RNA polymerase II

23091055|23453807

HgeneIKBKB

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15790681

HgeneIKBKB

GO:0071356

cellular response to tumor necrosis factor

23091055


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-69-8255-01AIKBKBchr8

42151030

+GOT1L1chr8

37796399

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000520810ENST00000307599IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
5CDS-intronENST00000520810ENST00000518826IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
In-frameENST00000416505ENST00000307599IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
5CDS-intronENST00000416505ENST00000518826IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
In-frameENST00000519735ENST00000307599IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
5CDS-intronENST00000519735ENST00000518826IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
In-frameENST00000520835ENST00000307599IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
5CDS-intronENST00000520835ENST00000518826IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
intron-3CDSENST00000379708ENST00000307599IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
intron-intronENST00000379708ENST00000518826IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
intron-3CDSENST00000518983ENST00000307599IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
intron-intronENST00000518983ENST00000518826IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
intron-3CDSENST00000522147ENST00000307599IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
intron-intronENST00000522147ENST00000518826IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
intron-3CDSENST00000522785ENST00000307599IKBKBchr8

42151030

+GOT1L1chr8

37796399

-
intron-intronENST00000522785ENST00000518826IKBKBchr8

42151030

+GOT1L1chr8

37796399

-

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FusionProtFeatures for IKBKB_GOT1L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IKBKB

O14920

GOT1L1

Q8NHS2

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimulisuch as inflammatory cytokines, bacterial or viral products, DNAdamages or other cellular stresses. Acts as part of the canonicalIKK complex in the conventional pathway of NF-kappa-B activationand phosphorylates inhibitors of NF-kappa-B on 2 critical serineresidues. These modifications allow polyubiquitination of theinhibitors and subsequent degradation by the proteasome. In turn,free NF-kappa-B is translocated into the nucleus and activates thetranscription of hundreds of genes involved in immune response,growth control, or protection against apoptosis. In addition tothe NF-kappa-B inhibitors, phosphorylates several other componentsof the signaling pathway including NEMO/IKBKG, NF-kappa-B subunitsRELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE.IKK-related kinase phosphorylations may prevent the overproductionof inflammatory mediators since they exert a negative regulationon canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor.Also phosphorylates other substrates including NCOA3, BCL10 andIRS1. Within the nucleus, acts as an adapter protein for NFKBIAdegradation in UV-induced NF-kappa-B activation.{ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:15084260,ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809,ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986,ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIKBKBchr8:42151030chr8:37796399ENST00000416505+42121_2970698Nucleotide bindingATP
HgeneIKBKBchr8:42151030chr8:37796399ENST00000519735+5921_29129257Nucleotide bindingATP
HgeneIKBKBchr8:42151030chr8:37796399ENST00000520810+52221_29129757Nucleotide bindingATP
HgeneIKBKBchr8:42151030chr8:37796399ENST00000520835+42121_29127755Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIKBKBchr8:42151030chr8:37796399ENST00000416505+42115_30070698DomainProtein kinase
HgeneIKBKBchr8:42151030chr8:37796399ENST00000519735+5915_300129257DomainProtein kinase
HgeneIKBKBchr8:42151030chr8:37796399ENST00000520810+52215_300129757DomainProtein kinase
HgeneIKBKBchr8:42151030chr8:37796399ENST00000520835+42115_300127755DomainProtein kinase
HgeneIKBKBchr8:42151030chr8:37796399ENST00000416505+421458_47970698RegionNote=Leucine-zipper
HgeneIKBKBchr8:42151030chr8:37796399ENST00000416505+421737_74270698RegionNote=NEMO-binding
HgeneIKBKBchr8:42151030chr8:37796399ENST00000519735+59458_479129257RegionNote=Leucine-zipper
HgeneIKBKBchr8:42151030chr8:37796399ENST00000519735+59737_742129257RegionNote=NEMO-binding
HgeneIKBKBchr8:42151030chr8:37796399ENST00000520810+522458_479129757RegionNote=Leucine-zipper
HgeneIKBKBchr8:42151030chr8:37796399ENST00000520810+522737_742129757RegionNote=NEMO-binding
HgeneIKBKBchr8:42151030chr8:37796399ENST00000520835+421458_479127755RegionNote=Leucine-zipper
HgeneIKBKBchr8:42151030chr8:37796399ENST00000520835+421737_742127755RegionNote=NEMO-binding


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FusionGeneSequence for IKBKB_GOT1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_IKBKB_ENST00000520810_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_513aa
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPND
LPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIVCMTNEGHPWVSLVVQKTRLQISQDPSLNYEYLPTMGLKSFIQASLALLFG
KHSQAIVENRVGGVHTVGDSGAFQLGVQFLRAWHKDARIVYIISSQKELHGLVFQDMGFTVYEYSVWDPKKLCMDPDILLNVVEQIPHGC
VLVMGNIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQGLYTSDLEEDTRILQYFVSQGFEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQ
QLLCVLSQLEGLAQALWLNPPNTGARVITSILCNPALLGEWKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNSQ

>In-frame_IKBKB_ENST00000416505_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_454aa
MSSDGTIRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIVCMTNEGHPWVSLVVQKTRL
QISQDPSLNYEYLPTMGLKSFIQASLALLFGKHSQAIVENRVGGVHTVGDSGAFQLGVQFLRAWHKDARIVYIISSQKELHGLVFQDMGF
TVYEYSVWDPKKLCMDPDILLNVVEQIPHGCVLVMGNIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQGLYTSDLEEDTRILQYFVSQG
FEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQQLLCVLSQLEGLAQALWLNPPNTGARVITSILCNPALLGEWKQSLKEVVENIMLTKEKV
KEKLQLLGTPGSWGHITEQSGTHGYLGLNSQQVEYLVRKKHIYIPKNGQINFSCINANNINYITEGINEAVLLTESSEMCLPKEKKTLIG

>In-frame_IKBKB_ENST00000519735_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_513aa
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPND
LPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIVCMTNEGHPWVSLVVQKTRLQISQDPSLNYEYLPTMGLKSFIQASLALLFG
KHSQAIVENRVGGVHTVGDSGAFQLGVQFLRAWHKDARIVYIISSQKELHGLVFQDMGFTVYEYSVWDPKKLCMDPDILLNVVEQIPHGC
VLVMGNIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQGLYTSDLEEDTRILQYFVSQGFEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQ
QLLCVLSQLEGLAQALWLNPPNTGARVITSILCNPALLGEWKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNSQ

>In-frame_IKBKB_ENST00000520835_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_511aa
MFSGGCHSPGFGRPSPAFPAPGSPPPAPRPCRQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLP
LLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIVCMTNEGHPWVSLVVQKTRLQISQDPSLNYEYLPTMGLKSFIQASLALLFGKH
SQAIVENRVGGVHTVGDSGAFQLGVQFLRAWHKDARIVYIISSQKELHGLVFQDMGFTVYEYSVWDPKKLCMDPDILLNVVEQIPHGCVL
VMGNIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQGLYTSDLEEDTRILQYFVSQGFEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQQL
LCVLSQLEGLAQALWLNPPNTGARVITSILCNPALLGEWKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNSQQV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_IKBKB_ENST00000520810_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_1539nt
ATGAGCTGGTCACCTTCCCTGACAACGCAGACATGTGGGGCCTGGGAAATGAAAGAGCGCCTTGGGACAGGGGGATTTGGAAATGTCATC
CGATGGCACAATCAGGAAACAGGTGAGCAGATTGCCATCAAGCAGTGCCGGCAGGAGCTCAGCCCCCGGAACCGAGAGCGGTGGTGCCTG
GAGATCCAGATCATGAGAAGGCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCCAATGAC
CTGCCCCTGCTGGCCATGGAGTACTGCCAAGGAGGAGATCTCCGGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAAGGT
GCCATCCTCACCTTGCTGAGTGACATTGTCTGCATGACAAATGAAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGACTACAG
ATTTCACAGGATCCCTCCCTGAATTATGAGTACTTGCCCACCATGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTCTTTGGA
AAGCACAGCCAAGCCATTGTGGAGAACAGGGTAGGGGGTGTACACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAGTTTCTC
AGAGCTTGGCATAAGGATGCTCGTATAGTTTACATCATCTCTTCTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGCTTTACA
GTTTATGAATACTCTGTCTGGGACCCCAAGAAGCTATGCATGGACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACATGGCTGT
GTCCTTGTGATGGGGAACATTATCGACTGCAAGTTGACACCAAGTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAGATATTC
CCATTTTTTGATATTCCCTGTCAAGGTTTATACACCAGTGACTTGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAAGGCTTT
GAGTTCTTCTGCAGCCAGTCTCTGTCCAAGAATTTTGGCATTTATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAACAACCAG
CAGCTGCTGTGTGTCCTCTCCCAGCTGGAAGGATTAGCCCAGGCCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATCACCTCC
ATCCTCTGCAACCCTGCTCTGCTGGGAGAATGGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAG
GAGAAACTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCCCAG
CAGGTGGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAAT
TACATCACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATTGGAATA

>In-frame_IKBKB_ENST00000416505_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_1362nt
ATGTCATCCGATGGCACAATCAGGCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCCAAT
GACCTGCCCCTGCTGGCCATGGAGTACTGCCAAGGAGGAGATCTCCGGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAA
GGTGCCATCCTCACCTTGCTGAGTGACATTGTCTGCATGACAAATGAAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGACTA
CAGATTTCACAGGATCCCTCCCTGAATTATGAGTACTTGCCCACCATGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTCTTT
GGAAAGCACAGCCAAGCCATTGTGGAGAACAGGGTAGGGGGTGTACACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAGTTT
CTCAGAGCTTGGCATAAGGATGCTCGTATAGTTTACATCATCTCTTCTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGCTTT
ACAGTTTATGAATACTCTGTCTGGGACCCCAAGAAGCTATGCATGGACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACATGGC
TGTGTCCTTGTGATGGGGAACATTATCGACTGCAAGTTGACACCAAGTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAGATA
TTCCCATTTTTTGATATTCCCTGTCAAGGTTTATACACCAGTGACTTGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAAGGC
TTTGAGTTCTTCTGCAGCCAGTCTCTGTCCAAGAATTTTGGCATTTATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAACAAC
CAGCAGCTGCTGTGTGTCCTCTCCCAGCTGGAAGGATTAGCCCAGGCCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATCACC
TCCATCCTCTGCAACCCTGCTCTGCTGGGAGAATGGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTG
AAGGAGAAACTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCC
CAGCAGGTGGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATA
AATTACATCACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATTGGA

>In-frame_IKBKB_ENST00000519735_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_1539nt
ATGAGCTGGTCACCTTCCCTGACAACGCAGACATGTGGGGCCTGGGAAATGAAAGAGCGCCTTGGGACAGGGGGATTTGGAAATGTCATC
CGATGGCACAATCAGGAAACAGGTGAGCAGATTGCCATCAAGCAGTGCCGGCAGGAGCTCAGCCCCCGGAACCGAGAGCGGTGGTGCCTG
GAGATCCAGATCATGAGAAGGCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCCAATGAC
CTGCCCCTGCTGGCCATGGAGTACTGCCAAGGAGGAGATCTCCGGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAAGGT
GCCATCCTCACCTTGCTGAGTGACATTGTCTGCATGACAAATGAAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGACTACAG
ATTTCACAGGATCCCTCCCTGAATTATGAGTACTTGCCCACCATGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTCTTTGGA
AAGCACAGCCAAGCCATTGTGGAGAACAGGGTAGGGGGTGTACACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAGTTTCTC
AGAGCTTGGCATAAGGATGCTCGTATAGTTTACATCATCTCTTCTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGCTTTACA
GTTTATGAATACTCTGTCTGGGACCCCAAGAAGCTATGCATGGACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACATGGCTGT
GTCCTTGTGATGGGGAACATTATCGACTGCAAGTTGACACCAAGTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAGATATTC
CCATTTTTTGATATTCCCTGTCAAGGTTTATACACCAGTGACTTGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAAGGCTTT
GAGTTCTTCTGCAGCCAGTCTCTGTCCAAGAATTTTGGCATTTATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAACAACCAG
CAGCTGCTGTGTGTCCTCTCCCAGCTGGAAGGATTAGCCCAGGCCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATCACCTCC
ATCCTCTGCAACCCTGCTCTGCTGGGAGAATGGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAG
GAGAAACTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCCCAG
CAGGTGGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAAT
TACATCACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATTGGAATA

>In-frame_IKBKB_ENST00000520835_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_1533nt
ATGTTTTCAGGGGGGTGTCATAGCCCCGGGTTTGGCCGCCCCAGCCCCGCCTTCCCCGCCCCGGGGAGCCCGCCCCCTGCCCCGCGTCCC
TGCCGACAGGAAACAGGTGAGCAGATTGCCATCAAGCAGTGCCGGCAGGAGCTCAGCCCCCGGAACCGAGAGCGGTGGTGCCTGGAGATC
CAGATCATGAGAAGGCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCCAATGACCTGCCC
CTGCTGGCCATGGAGTACTGCCAAGGAGGAGATCTCCGGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAAGGTGCCATC
CTCACCTTGCTGAGTGACATTGTCTGCATGACAAATGAAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGACTACAGATTTCA
CAGGATCCCTCCCTGAATTATGAGTACTTGCCCACCATGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTCTTTGGAAAGCAC
AGCCAAGCCATTGTGGAGAACAGGGTAGGGGGTGTACACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAGTTTCTCAGAGCT
TGGCATAAGGATGCTCGTATAGTTTACATCATCTCTTCTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGCTTTACAGTTTAT
GAATACTCTGTCTGGGACCCCAAGAAGCTATGCATGGACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACATGGCTGTGTCCTT
GTGATGGGGAACATTATCGACTGCAAGTTGACACCAAGTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAGATATTCCCATTT
TTTGATATTCCCTGTCAAGGTTTATACACCAGTGACTTGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAAGGCTTTGAGTTC
TTCTGCAGCCAGTCTCTGTCCAAGAATTTTGGCATTTATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAACAACCAGCAGCTG
CTGTGTGTCCTCTCCCAGCTGGAAGGATTAGCCCAGGCCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATCACCTCCATCCTC
TGCAACCCTGCTCTGCTGGGAGAATGGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAA
CTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCCCAGCAGGTG
GAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAATTACATC
ACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATTGGAATAAAACTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_IKBKB_ENST00000520810_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_1737nt
GTGACGTCAGAGCAGGAAGTGTTTGAGGAAGTCGCGCCGCGCTGCCCGCGTTAAGATTCCCGCATTTTAATGTTTTCAGGGGGGTGTCAT
AGCCCCGGGTTTGGCCGCCCCAGCCCCGCCTTCCCCGCCCCGGGGAGCCCGCCCCCTGCCCCGCGTCCCTGCCGACAGAGTTAGCACGAC
ATCAGTATGAGCTGGTCACCTTCCCTGACAACGCAGACATGTGGGGCCTGGGAAATGAAAGAGCGCCTTGGGACAGGGGGATTTGGAAAT
GTCATCCGATGGCACAATCAGGAAACAGGTGAGCAGATTGCCATCAAGCAGTGCCGGCAGGAGCTCAGCCCCCGGAACCGAGAGCGGTGG
TGCCTGGAGATCCAGATCATGAGAAGGCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCC
AATGACCTGCCCCTGCTGGCCATGGAGTACTGCCAAGGAGGAGATCTCCGGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGG
GAAGGTGCCATCCTCACCTTGCTGAGTGACATTGTCTGCATGACAAATGAAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGA
CTACAGATTTCACAGGATCCCTCCCTGAATTATGAGTACTTGCCCACCATGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTC
TTTGGAAAGCACAGCCAAGCCATTGTGGAGAACAGGGTAGGGGGTGTACACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAG
TTTCTCAGAGCTTGGCATAAGGATGCTCGTATAGTTTACATCATCTCTTCTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGC
TTTACAGTTTATGAATACTCTGTCTGGGACCCCAAGAAGCTATGCATGGACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACAT
GGCTGTGTCCTTGTGATGGGGAACATTATCGACTGCAAGTTGACACCAAGTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAG
ATATTCCCATTTTTTGATATTCCCTGTCAAGGTTTATACACCAGTGACTTGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAA
GGCTTTGAGTTCTTCTGCAGCCAGTCTCTGTCCAAGAATTTTGGCATTTATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAAC
AACCAGCAGCTGCTGTGTGTCCTCTCCCAGCTGGAAGGATTAGCCCAGGCCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATC
ACCTCCATCCTCTGCAACCCTGCTCTGCTGGGAGAATGGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAA
GTGAAGGAGAAACTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAAC
TCCCAGCAGGTGGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAAC
ATAAATTACATCACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATT

>In-frame_IKBKB_ENST00000416505_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_1628nt
GGAAGTGTTTGAGGAAGTCGCGCCGCGCTGCCCGCGTTAAGATTCCCGCATTTTAATGTTTTCAGGGGGGTGTCATAGCCCCGGGTTTGG
CCGCCCCAGCCCCGCCTTCCCCGCCCCGGGGAGCCCGCCCCCTGCCCCGCGTCCCTGCCGACAGAGTTAGCACGACATCAGTATGAGCTG
GTCACCTTCCCTGACAACGCAGACATGTGGGGCCTGGGAAATGAAAGAGCGCCTTGGGACAGGGGGATTTGGAAATGTCATCCGATGGCA
CAATCAGGCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCCAATGACCTGCCCCTGCTGG
CCATGGAGTACTGCCAAGGAGGAGATCTCCGGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAAGGTGCCATCCTCACCT
TGCTGAGTGACATTGTCTGCATGACAAATGAAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGACTACAGATTTCACAGGATC
CCTCCCTGAATTATGAGTACTTGCCCACCATGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTCTTTGGAAAGCACAGCCAAG
CCATTGTGGAGAACAGGGTAGGGGGTGTACACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAGTTTCTCAGAGCTTGGCATA
AGGATGCTCGTATAGTTTACATCATCTCTTCTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGCTTTACAGTTTATGAATACT
CTGTCTGGGACCCCAAGAAGCTATGCATGGACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACATGGCTGTGTCCTTGTGATGG
GGAACATTATCGACTGCAAGTTGACACCAAGTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAGATATTCCCATTTTTTGATA
TTCCCTGTCAAGGTTTATACACCAGTGACTTGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAAGGCTTTGAGTTCTTCTGCA
GCCAGTCTCTGTCCAAGAATTTTGGCATTTATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAACAACCAGCAGCTGCTGTGTG
TCCTCTCCCAGCTGGAAGGATTAGCCCAGGCCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATCACCTCCATCCTCTGCAACC
CTGCTCTGCTGGGAGAATGGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCCAGC
TCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCCCAGCAGGTGGAATACC
TGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAATTACATCACTGAGG
GCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATTGGAATAAAACTTTAGTCTT

>In-frame_IKBKB_ENST00000519735_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_1721nt
AAGTGTTTGAGGAAGTCGCGCCGCGCTGCCCGCGTTAAGATTCCCGCATTTTAATGTTTTCAGGGGGGTGTCATAGCCCCGGGTTTGGCC
GCCCCAGCCCCGCCTTCCCCGCCCCGGGGAGCCCGCCCCCTGCCCCGCGTCCCTGCCGACAGAGTTAGCACGACATCAGTATGAGCTGGT
CACCTTCCCTGACAACGCAGACATGTGGGGCCTGGGAAATGAAAGAGCGCCTTGGGACAGGGGGATTTGGAAATGTCATCCGATGGCACA
ATCAGGAAACAGGTGAGCAGATTGCCATCAAGCAGTGCCGGCAGGAGCTCAGCCCCCGGAACCGAGAGCGGTGGTGCCTGGAGATCCAGA
TCATGAGAAGGCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCCAATGACCTGCCCCTGC
TGGCCATGGAGTACTGCCAAGGAGGAGATCTCCGGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAAGGTGCCATCCTCA
CCTTGCTGAGTGACATTGTCTGCATGACAAATGAAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGACTACAGATTTCACAGG
ATCCCTCCCTGAATTATGAGTACTTGCCCACCATGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTCTTTGGAAAGCACAGCC
AAGCCATTGTGGAGAACAGGGTAGGGGGTGTACACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAGTTTCTCAGAGCTTGGC
ATAAGGATGCTCGTATAGTTTACATCATCTCTTCTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGCTTTACAGTTTATGAAT
ACTCTGTCTGGGACCCCAAGAAGCTATGCATGGACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACATGGCTGTGTCCTTGTGA
TGGGGAACATTATCGACTGCAAGTTGACACCAAGTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAGATATTCCCATTTTTTG
ATATTCCCTGTCAAGGTTTATACACCAGTGACTTGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAAGGCTTTGAGTTCTTCT
GCAGCCAGTCTCTGTCCAAGAATTTTGGCATTTATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAACAACCAGCAGCTGCTGT
GTGTCCTCTCCCAGCTGGAAGGATTAGCCCAGGCCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATCACCTCCATCCTCTGCA
ACCCTGCTCTGCTGGGAGAATGGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCC
AGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCCCAGCAGGTGGAAT
ACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAATTACATCACTG
AGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATTGGAATAAAACTTTAGT

>In-frame_IKBKB_ENST00000520835_chr8_42151030_+_GOT1L1_ENST00000307599_chr8_37796399_-_1598nt
AAGTGTTTGAGGAAGTCGCGCCGCGCTGCCCGCGTTAAGATTCCCGCATTTTAATGTTTTCAGGGGGGTGTCATAGCCCCGGGTTTGGCC
GCCCCAGCCCCGCCTTCCCCGCCCCGGGGAGCCCGCCCCCTGCCCCGCGTCCCTGCCGACAGGAAACAGGTGAGCAGATTGCCATCAAGC
AGTGCCGGCAGGAGCTCAGCCCCCGGAACCGAGAGCGGTGGTGCCTGGAGATCCAGATCATGAGAAGGCTGACCCACCCCAATGTGGTGG
CTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCCAATGACCTGCCCCTGCTGGCCATGGAGTACTGCCAAGGAGGAGATCTCC
GGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAAGGTGCCATCCTCACCTTGCTGAGTGACATTGTCTGCATGACAAATG
AAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGACTACAGATTTCACAGGATCCCTCCCTGAATTATGAGTACTTGCCCACCA
TGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTCTTTGGAAAGCACAGCCAAGCCATTGTGGAGAACAGGGTAGGGGGTGTAC
ACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAGTTTCTCAGAGCTTGGCATAAGGATGCTCGTATAGTTTACATCATCTCTT
CTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGCTTTACAGTTTATGAATACTCTGTCTGGGACCCCAAGAAGCTATGCATGG
ACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACATGGCTGTGTCCTTGTGATGGGGAACATTATCGACTGCAAGTTGACACCAA
GTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAGATATTCCCATTTTTTGATATTCCCTGTCAAGGTTTATACACCAGTGACT
TGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAAGGCTTTGAGTTCTTCTGCAGCCAGTCTCTGTCCAAGAATTTTGGCATTT
ATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAACAACCAGCAGCTGCTGTGTGTCCTCTCCCAGCTGGAAGGATTAGCCCAGG
CCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATCACCTCCATCCTCTGCAACCCTGCTCTGCTGGGAGAATGGAAGCAGAGTC
TAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACA
TCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCCCAGCAGGTGGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCA
AGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAATTACATCACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGA


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FusionGenePPI for IKBKB_GOT1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IKBKBTRPC4AP, PPM1B, NFKB1, BTRC, MAP3K13, PRDX3, IRS1, PRKCQ, CHUK, IKBKG, CDC37, PRKDC, TNFRSF1A, TRAF2, CTNNB1, IRAK1, NFKBIA, FANCA, MAP3K11, EIF2AK2, CASP8, NCOA3, IKBKAP, TNFAIP3, MAP3K14, TRAF3IP2, NFKBIB, IKBKB, MAP3K1, MAP3K7, CUEDC2, PPP1CA, PPP1R15A, RELA, AKT1, TNF, PRKCA, PRKCI, PRKCD, DUSP1, TP53, KEAP1, CUL3, HTT, COPS3, COPS4, COPS5, COPS7A, CUL1, JUN, ERC1, TRIM21, HNRNPU, TRIM40, FKBP4, FKBP5, PYGL, CSNK2B, MAPK14, NLRX1, PLK1, MUC1, TP63, HOMER3, IKBKE, NEDD4L, RIPK1, PELI1, TRAF6, USP4, BRAP, BCL10, TNIP2, SRC, PPP2R3C, NLRP2, HSP90AA1, EGLN3, TRIM27, TP73, TRAPPC9, FAF1, PPP2CA, MEOX2, CDKN2A, TRAF1, FOXO3, STAP2, CSF2RA, CSF2RB, TSC1, CREBBP, NAA20, BCL2, DPP4, TAB1, PRKCE, HSPB1, PYCARD, NLRC5, TAB2, AURKA, TPX2, NGFR, SASH1, TFAP2C, FLNC, ROCK1, MTOR, RPTOR, RICTOR, PPARG, SHARPIN, DHCR24, RAN, SLC25A13, SLC25A22, CD40, MAVS, BIRC3, HSP90AB1, CLTC, PRKCB, STK26, COMMD7, MACROD1, LATS2, GLI1, ITCH, USP18, TWIST1, SMN1, KLHL21, TAB3, PSG1, UBC, MALT1, HIF1A, EPAS1, TNIK, IFIT5GOT1L1GRK5, SERPINA1, APOA1, GOT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IKBKB_GOT1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIKBKBO14920DB00244MesalazineInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved
HgeneIKBKBO14920DB00795SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved
HgeneIKBKBO14920DB00995AuranofinInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved|investigational
HgeneIKBKBO14920DB01169Arsenic trioxideInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved|investigational
HgeneIKBKBO14920DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved|investigational
HgeneIKBKBO14920DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved|vet_approved

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RelatedDiseases for IKBKB_GOT1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource