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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17312

FusionGeneSummary for IKBKAP_MARK3

check button Fusion gene summary
Fusion gene informationFusion gene name: IKBKAP_MARK3
Fusion gene ID: 17312
HgeneTgene
Gene symbol

IKBKAP

MARK3

Gene ID

4140

Gene namemicrotubule affinity regulating kinase 3
SynonymsCTAK1|KP78|PAR1A|Par-1a
Cytomap

14q32.32-q32.33

Type of geneprotein-coding
DescriptionMAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78
Modification date20180523
UniProtAcc

P27448

Ensembl transtripts involved in fusion geneENST00000374647, ENST00000537196, 
ENST00000467959, 
ENST00000440884, 
ENST00000416682, ENST00000429436, 
ENST00000303622, ENST00000216288, 
ENST00000553942, ENST00000335102, 
ENST00000561071, 
Fusion gene scores* DoF score4 X 3 X 4=488 X 10 X 6=480
# samples 415
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/480*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IKBKAP [Title/Abstract] AND MARK3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMARK3

GO:0018105

peptidyl-serine phosphorylation

9543386

TgeneMARK3

GO:0032092

positive regulation of protein binding

9543386

TgeneMARK3

GO:0035331

negative regulation of hippo signaling

28087714

TgeneMARK3

GO:0036289

peptidyl-serine autophosphorylation

9543386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE073873IKBKAPchr9

111695768

+MARK3chr14

103932419

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000374647ENST00000440884IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000374647ENST00000416682IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000374647ENST00000429436IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000374647ENST00000303622IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000374647ENST00000216288IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000374647ENST00000553942IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000374647ENST00000335102IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-intronENST00000374647ENST00000561071IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000537196ENST00000440884IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000537196ENST00000416682IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000537196ENST00000429436IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000537196ENST00000303622IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000537196ENST00000216288IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000537196ENST00000553942IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000537196ENST00000335102IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-intronENST00000537196ENST00000561071IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000467959ENST00000440884IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000467959ENST00000416682IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000467959ENST00000429436IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000467959ENST00000303622IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000467959ENST00000216288IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000467959ENST00000553942IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-3CDSENST00000467959ENST00000335102IKBKAPchr9

111695768

+MARK3chr14

103932419

-
intron-intronENST00000467959ENST00000561071IKBKAPchr9

111695768

+MARK3chr14

103932419

-

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FusionProtFeatures for IKBKAP_MARK3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IKBKAP

MARK3

P27448

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IKBKAP_MARK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IKBKAP_MARK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IKBKAP_MARK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IKBKAP_MARK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource