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Fusion gene ID: 17309 |
FusionGeneSummary for IKBIP_NR2C1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IKBIP_NR2C1 | Fusion gene ID: 17309 | Hgene | Tgene | Gene symbol | IKBIP | NR2C1 | Gene ID | 121457 | 7181 |
| Gene name | IKBKB interacting protein | nuclear receptor subfamily 2 group C member 1 | |
| Synonyms | IKIP | TR2 | |
| Cytomap | 12q23.1 | 12q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inhibitor of nuclear factor kappa-B kinase-interacting proteinI kappa B kinase interacting proteinIKK interacting proteini kappa-B kinase-interacting protein | nuclear receptor subfamily 2 group C member 1TR2 nuclear hormone receptornuclear receptor subfamily 2, group C isoformorphan nuclear receptor TR2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q70UQ0 | P13056 | |
| Ensembl transtripts involved in fusion gene | ENST00000393042, ENST00000420861, ENST00000342502, ENST00000299157, | ENST00000333003, ENST00000545833, ENST00000393101, ENST00000330677, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 2 X 3=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: IKBIP [Title/Abstract] AND NR2C1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-23-1122-01A | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000393042 | ENST00000333003 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| intron-5UTR | ENST00000393042 | ENST00000545833 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| intron-5UTR | ENST00000393042 | ENST00000393101 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| intron-5UTR | ENST00000393042 | ENST00000330677 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| intron-3CDS | ENST00000420861 | ENST00000333003 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| intron-5UTR | ENST00000420861 | ENST00000545833 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| intron-5UTR | ENST00000420861 | ENST00000393101 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| intron-5UTR | ENST00000420861 | ENST00000330677 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| In-frame | ENST00000342502 | ENST00000333003 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| 5CDS-5UTR | ENST00000342502 | ENST00000545833 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| 5CDS-5UTR | ENST00000342502 | ENST00000393101 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| 5CDS-5UTR | ENST00000342502 | ENST00000330677 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| In-frame | ENST00000299157 | ENST00000333003 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| 5CDS-5UTR | ENST00000299157 | ENST00000545833 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| 5CDS-5UTR | ENST00000299157 | ENST00000393101 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
| 5CDS-5UTR | ENST00000299157 | ENST00000330677 | IKBIP | chr12 | 99028074 | - | NR2C1 | chr12 | 95445719 | - |
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FusionProtFeatures for IKBIP_NR2C1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IKBIP | NR2C1 |
| Target of p53/TP53 with pro-apoptotic function.{ECO:0000269|PubMed:15389287}. | Orphan nuclear receptor. Binds the IR7 element in thepromoter of its own gene in an autoregulatory negative feedbackmechanism. Primarily repressor of a broad range of genes. Binds tohormone response elements (HREs) consisting of two 5'-AGGTCA-3'half site direct repeat consensus sequences. Together with NR2C2,forms the core of the DRED (direct repeat erythroid-definitive)complex that represses embryonic and fetal globin transcription.Also activator of OCT4 gene expression. May be involved in stemcell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.{ECO:0000269|PubMed:12093804, ECO:0000269|PubMed:17010934}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IKBIP_NR2C1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_IKBIP_ENST00000342502_chr12_99028074_-_NR2C1_ENST00000333003_chr12_95445719_-_442aa MSEVKSRKKSGPKGAPAAEPGKRSEGGKTPVARSSGGGGWADPRTCLSLLSLGTCLGLAWFVFQQSEKFAKVENQYQLLKLETNEFQQLQ SKISLISEKAESCQGDLSTLANVVTSLANLGKTKDLSQNSNEMSMIESLSNDDTSLCEFQEMQTNGDVSRAFDTLAKALNPGESTACQSS VAGMEGSVHLITGDSSINYTEKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNE LFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSTERRKLLMEHIFKLQEFCNSMVKLCIDGYEYAYLKAIVLFSPDHPSLENMEQIE >In-frame_IKBIP_ENST00000299157_chr12_99028074_-_NR2C1_ENST00000333003_chr12_95445719_-_442aa MSEVKSRKKSGPKGAPAAEPGKRSEGGKTPVARSSGGGGWADPRTCLSLLSLGTCLGLAWFVFQQSEKFAKVENQYQLLKLETNEFQQLQ SKISLISEKAESCQGDLSTLANVVTSLANLGKTKDLSQNSNEMSMIESLSNDDTSLCEFQEMQTNGDVSRAFDTLAKALNPGESTACQSS VAGMEGSVHLITGDSSINYTEKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNE LFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSTERRKLLMEHIFKLQEFCNSMVKLCIDGYEYAYLKAIVLFSPDHPSLENMEQIE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_IKBIP_ENST00000342502_chr12_99028074_-_NR2C1_ENST00000333003_chr12_95445719_-_1326nt ATGTCTGAGGTGAAGAGCCGGAAGAAGTCGGGGCCCAAGGGAGCCCCTGCTGCGGAGCCCGGGAAGCGGAGCGAGGGCGGGAAGACCCCC GTGGCCCGGAGCAGCGGAGGCGGGGGCTGGGCAGACCCCCGAACGTGCCTGAGCCTGCTGTCGCTGGGGACGTGCCTGGGCCTGGCCTGG TTTGTATTTCAGCAGTCAGAAAAATTTGCAAAGGTGGAAAACCAATACCAGTTACTGAAACTAGAAACCAATGAATTCCAACAACTTCAA AGTAAAATCAGTTTAATTTCAGAAAAGGCTGAATCATGTCAGGGAGATTTAAGTACATTGGCCAATGTGGTTACATCATTAGCGAATCTT GGAAAAACTAAAGATCTTTCTCAAAATAGTAATGAAATGTCTATGATTGAAAGCTTAAGCAATGATGATACCTCTTTGTGTGAATTTCAA GAAATGCAGACCAACGGTGATGTTTCAAGGGCATTTGACACTCTTGCAAAAGCATTGAATCCTGGAGAGAGCACAGCCTGCCAGAGCTCA GTAGCGGGCATGGAAGGAAGTGTACACCTAATCACTGGAGATTCAAGCATAAATTACACCGAAAAAGAGGGGCCACTTCTCAGCGATTCA CATGTAGCTTTCAGGCTCACCATGCCTTCTCCTATGCCTGAGTACCTGAATGTGCACTACATTGGGGAGTCTGCCTCCAGACTGCTGTTC TTATCAATGCACTGGGCACTTTCGATTCCTTCTTTCCAGGCTCTAGGGCAAGAAAACAGCATATCACTGGTGAAAGCTTACTGGAATGAA CTTTTTACTCTTGGTCTTGCCCAGTGCTGGCAAGTGATGAATGTAGCAACTATATTAGCAACATTTGTCAATTGTCTTCACAATAGTCTT CAACAAGATAAAATGTCAACAGAAAGAAGAAAATTATTGATGGAGCACATCTTCAAACTACAGGAGTTTTGTAACAGCATGGTTAAACTC TGCATTGATGGATACGAATATGCCTACCTGAAGGCAATAGTACTCTTCAGTCCAGATCATCCAAGCCTAGAAAACATGGAACAGATAGAG AAATTTCAGGAAAAGGCTTATGTGGAATTCCAAGATTATATAACCAAAACATATCCAGATGACACCTACAGGTTATCCAGACTACTACTC AGATTGCCAGCTTTAAGACTGATGAATGCTACCATCACTGAAGAATTGTTTTTCAAAGGTCTCATTGGCAATATACGAATTGACAGTGTT >In-frame_IKBIP_ENST00000299157_chr12_99028074_-_NR2C1_ENST00000333003_chr12_95445719_-_1326nt ATGTCTGAGGTGAAGAGCCGGAAGAAGTCGGGGCCCAAGGGAGCCCCTGCTGCGGAGCCCGGGAAGCGGAGCGAGGGCGGGAAGACCCCC GTGGCCCGGAGCAGCGGAGGCGGGGGCTGGGCAGACCCCCGAACGTGCCTGAGCCTGCTGTCGCTGGGGACGTGCCTGGGCCTGGCCTGG TTTGTATTTCAGCAGTCAGAAAAATTTGCAAAGGTGGAAAACCAATACCAGTTACTGAAACTAGAAACCAATGAATTCCAACAACTTCAA AGTAAAATCAGTTTAATTTCAGAAAAGGCTGAATCATGTCAGGGAGATTTAAGTACATTGGCCAATGTGGTTACATCATTAGCGAATCTT GGAAAAACTAAAGATCTTTCTCAAAATAGTAATGAAATGTCTATGATTGAAAGCTTAAGCAATGATGATACCTCTTTGTGTGAATTTCAA GAAATGCAGACCAACGGTGATGTTTCAAGGGCATTTGACACTCTTGCAAAAGCATTGAATCCTGGAGAGAGCACAGCCTGCCAGAGCTCA GTAGCGGGCATGGAAGGAAGTGTACACCTAATCACTGGAGATTCAAGCATAAATTACACCGAAAAAGAGGGGCCACTTCTCAGCGATTCA CATGTAGCTTTCAGGCTCACCATGCCTTCTCCTATGCCTGAGTACCTGAATGTGCACTACATTGGGGAGTCTGCCTCCAGACTGCTGTTC TTATCAATGCACTGGGCACTTTCGATTCCTTCTTTCCAGGCTCTAGGGCAAGAAAACAGCATATCACTGGTGAAAGCTTACTGGAATGAA CTTTTTACTCTTGGTCTTGCCCAGTGCTGGCAAGTGATGAATGTAGCAACTATATTAGCAACATTTGTCAATTGTCTTCACAATAGTCTT CAACAAGATAAAATGTCAACAGAAAGAAGAAAATTATTGATGGAGCACATCTTCAAACTACAGGAGTTTTGTAACAGCATGGTTAAACTC TGCATTGATGGATACGAATATGCCTACCTGAAGGCAATAGTACTCTTCAGTCCAGATCATCCAAGCCTAGAAAACATGGAACAGATAGAG AAATTTCAGGAAAAGGCTTATGTGGAATTCCAAGATTATATAACCAAAACATATCCAGATGACACCTACAGGTTATCCAGACTACTACTC AGATTGCCAGCTTTAAGACTGATGAATGCTACCATCACTGAAGAATTGTTTTTCAAAGGTCTCATTGGCAATATACGAATTGACAGTGTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_IKBIP_ENST00000342502_chr12_99028074_-_NR2C1_ENST00000333003_chr12_95445719_-_3738nt GCTAAGCCTCAGGGACGCGCCGCGTTCCCACCAATGCCGGACTCGGGCAGCGGCGGCGCGCCCGACGTGGCGCGCGCGACCCCTTCGTCC TGCCCCTCCTCCTCGGGTCCCGTCGGCCTGCGCGCGCCCGGGAGTTTGAATTTCCTCGGATTTGGAGCAATATCGCAGTGGAAGGCGCTG TGGGTTGAGGTCGCCGCCCACCTCTCCTAGGGGAACTATGGAGCTGGCAGCTGAAAGACTCAGTGAAGCAACGAGGATGCCGGGGAGAGG GAAGGGGCTGGGCTCTGGGCGGTGCCAAGTCTGTGAGGGGGCGCGGTCACCGCCCAGGGTTCCCACGAACGCCAAGGCGGCCACGTCCTG CTCCCCCTGGTGAAGAAGCTGCCCTGGGCTTGTCGTCCTAGGGTCTCCAGACATGTCTGAGGTGAAGAGCCGGAAGAAGTCGGGGCCCAA GGGAGCCCCTGCTGCGGAGCCCGGGAAGCGGAGCGAGGGCGGGAAGACCCCCGTGGCCCGGAGCAGCGGAGGCGGGGGCTGGGCAGACCC CCGAACGTGCCTGAGCCTGCTGTCGCTGGGGACGTGCCTGGGCCTGGCCTGGTTTGTATTTCAGCAGTCAGAAAAATTTGCAAAGGTGGA AAACCAATACCAGTTACTGAAACTAGAAACCAATGAATTCCAACAACTTCAAAGTAAAATCAGTTTAATTTCAGAAAAGGCTGAATCATG TCAGGGAGATTTAAGTACATTGGCCAATGTGGTTACATCATTAGCGAATCTTGGAAAAACTAAAGATCTTTCTCAAAATAGTAATGAAAT GTCTATGATTGAAAGCTTAAGCAATGATGATACCTCTTTGTGTGAATTTCAAGAAATGCAGACCAACGGTGATGTTTCAAGGGCATTTGA CACTCTTGCAAAAGCATTGAATCCTGGAGAGAGCACAGCCTGCCAGAGCTCAGTAGCGGGCATGGAAGGAAGTGTACACCTAATCACTGG AGATTCAAGCATAAATTACACCGAAAAAGAGGGGCCACTTCTCAGCGATTCACATGTAGCTTTCAGGCTCACCATGCCTTCTCCTATGCC TGAGTACCTGAATGTGCACTACATTGGGGAGTCTGCCTCCAGACTGCTGTTCTTATCAATGCACTGGGCACTTTCGATTCCTTCTTTCCA GGCTCTAGGGCAAGAAAACAGCATATCACTGGTGAAAGCTTACTGGAATGAACTTTTTACTCTTGGTCTTGCCCAGTGCTGGCAAGTGAT GAATGTAGCAACTATATTAGCAACATTTGTCAATTGTCTTCACAATAGTCTTCAACAAGATAAAATGTCAACAGAAAGAAGAAAATTATT GATGGAGCACATCTTCAAACTACAGGAGTTTTGTAACAGCATGGTTAAACTCTGCATTGATGGATACGAATATGCCTACCTGAAGGCAAT AGTACTCTTCAGTCCAGATCATCCAAGCCTAGAAAACATGGAACAGATAGAGAAATTTCAGGAAAAGGCTTATGTGGAATTCCAAGATTA TATAACCAAAACATATCCAGATGACACCTACAGGTTATCCAGACTACTACTCAGATTGCCAGCTTTAAGACTGATGAATGCTACCATCAC TGAAGAATTGTTTTTCAAAGGTCTCATTGGCAATATACGAATTGACAGTGTTATCCCACATATTTTGAAAATGGAGCCTGCAGATTATAA CTCTCAAATAATTGGTCACAGCATTTGAAAACTGTGACTGCAGTGCTGTAAACTTAACTGTTCTTTGCCAGAACACAAGACACCAAATTG AACTCACTGCTTTTGAGGCATCTGGAAATTTTTACTTTAAAAAGTAACCAGAATCCAAGGTATTTTTATTTTAGCTTCCCTTAAGAATTT TTGAAGTGACTGGGCAGGCAGCAGAAATTAAATGAATTTTTCTTCCTGATTCCTTTAAATGAATATGAAACACTACAAATTTATTCTTGG TGAAGATGATACCTGAAGCTGTCACCTCTTGATTATCTAAACTAAGCGCTCATTCTATTTTATAAAACAAATAAATTAGTCTCTTTTTTC TGAATTGTGTTCTAGTCATATTTAACTTCATTATGAACTAGTAAAAATACTTAATGGTCAGAAATCCCTAAGGAGTTAGTTCCTTGCATT TTACTCTGCCATAATAATTTTTGTTTAATTACCATATCAAAATAAGATTATTTTATGCTTACTGGTATAATGACAGTATTAGAACTATAG GAAATAATTGAATACATATTTTTTGTCTTCTCTAAATATCATGGTGTCCCTTAGCATATACTACTCTCATTGCTGGCAGTGAGACAGGCC ATTCATGATCTTAAGAGTTGCCATTTTTAATGTATATTATTAGTTACAAGCACTTTATATAGCAGAAAATTGTTTTTGAGAATAAGCTAG TGTTGATATTTTAATATTTTTAGCTTACTGCTCGTGTTTTTGTTTTTGTTTTCGTTTATAGAGGTGGGTTTCACTGTTGCCCAGGCTGGT CTCAAACTCCTGGGCTCAAGTGATCCTGCCTCAGCCTCCCAAAGTACTGGGATTACAGGCGCGTGCCACCGTGCCTGGCCTACTGCTGTC TTTGAAAATAATAGAGACTAGCCAGGTGTAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATTGCTTGAGCT CAGGAGTTCGAGACCAGCCTGGGCAATATAGCAAGACCTCGTCTCTGTAAAAAGAAAGAAAGTAATAAAGACTAATTGAGCCCAAAATGT TTCACTATTTCAAAAAAGATATTTAAATTGTTGCTCTTTCATTCCATAAAAAGGATCTGATCTCTCTCCCACTTTTCTGACCTGAGTTAG AGCTTCCCAAACCTGTCATGTATGGGTTTTAGCCAATTTCTTTTAGATCACTAAAAAAACTCACCCAATATGTCAAATAATGGATTTATC ATAGCCAGTACATGTTCTCAAGGCAAGTTTAAACATTATTTTGAAGCTATTGATAATTTTTTAAAATAAAGAAATATTCACTGATTTTTT TCACTGTAAAGCACGGGAGGGCTGCTTTAACAACAGTATAAGAATCAGCCTGAAGCCTTGTTACTGCTACAACAAATTCATTTTAGACTC CTCGGATGTCTTCCACAGTAATTTATTCTTTTAGCAAACCTGATACTGATAACTGTTTCTTTGCTTTGATTTCTTGATGAATTATTTTGG TATGTTTGTTGATTTTTAAAGCAAACACGGATAATGCACTCAGAGTACATTTTTTGTAAAGATTTTTGCAATAGAAGAAAAGTGAAGTTT TTGTGGGGATGTGGATTTTATTGCTTACTACTTTATAGTAATCAAAAGTTTGAAAATATCAACTTACAGTCTTTACCAGTTTACTAAGGG AAACTTTTTTCCCTATTTAAAACATGATCTTAGTCAACAATTTTATTTATAATTATCAGCTAAATTACATTTAGTATAATACTCAAATGG AAAAATCAGTAGTTTATACCTTTATAAATACAGTTTAGTAAGCCAAGGAATCAGGGAAATAATCCTTTAAAATAATGTACTAATAGTTAA GATGTTTCAGGTGTTTTTTCTGATTAAATTTGCTACTATATTTGGAAGACTTTAAAACTATATTAAAATGTGACTTGCATTACAAATTTC >In-frame_IKBIP_ENST00000299157_chr12_99028074_-_NR2C1_ENST00000333003_chr12_95445719_-_3700nt GGACTCGGGCAGCGGCGGCGCGCCCGACGTGGCGCGCGCGACCCCTTCGTCCTGCCCCTCCTCCTCGGGTCCCGTCGGCCTGCGCGCGCC CGGGAGTTTGAATTTCCTCGGATTTGGAGCAATATCGCAGTGGAAGGCGCTGTGGGTTGAGGTCGCCGCCCACCTCTCCTAGGGGAACTA TGGAGCTGGCAGCTGAAAGACTCAGTGAAGCAACGAGGATGCCGGGGAGAGGGAAGGGGCTGGGCTCTGGGCGGTGCCAAGTCTGTGAGG GGGCGCGGTCACCGCCCAGGGTTCCCACGAACGCCAAGGCGGCCACGTCCTGCTCCCCCTGGTGAAGAAGCTGCCCTGGGCTTGTCGTCC TAGGGTCTCCAGACATGTCTGAGGTGAAGAGCCGGAAGAAGTCGGGGCCCAAGGGAGCCCCTGCTGCGGAGCCCGGGAAGCGGAGCGAGG GCGGGAAGACCCCCGTGGCCCGGAGCAGCGGAGGCGGGGGCTGGGCAGACCCCCGAACGTGCCTGAGCCTGCTGTCGCTGGGGACGTGCC TGGGCCTGGCCTGGTTTGTATTTCAGCAGTCAGAAAAATTTGCAAAGGTGGAAAACCAATACCAGTTACTGAAACTAGAAACCAATGAAT TCCAACAACTTCAAAGTAAAATCAGTTTAATTTCAGAAAAGGCTGAATCATGTCAGGGAGATTTAAGTACATTGGCCAATGTGGTTACAT CATTAGCGAATCTTGGAAAAACTAAAGATCTTTCTCAAAATAGTAATGAAATGTCTATGATTGAAAGCTTAAGCAATGATGATACCTCTT TGTGTGAATTTCAAGAAATGCAGACCAACGGTGATGTTTCAAGGGCATTTGACACTCTTGCAAAAGCATTGAATCCTGGAGAGAGCACAG CCTGCCAGAGCTCAGTAGCGGGCATGGAAGGAAGTGTACACCTAATCACTGGAGATTCAAGCATAAATTACACCGAAAAAGAGGGGCCAC TTCTCAGCGATTCACATGTAGCTTTCAGGCTCACCATGCCTTCTCCTATGCCTGAGTACCTGAATGTGCACTACATTGGGGAGTCTGCCT CCAGACTGCTGTTCTTATCAATGCACTGGGCACTTTCGATTCCTTCTTTCCAGGCTCTAGGGCAAGAAAACAGCATATCACTGGTGAAAG CTTACTGGAATGAACTTTTTACTCTTGGTCTTGCCCAGTGCTGGCAAGTGATGAATGTAGCAACTATATTAGCAACATTTGTCAATTGTC TTCACAATAGTCTTCAACAAGATAAAATGTCAACAGAAAGAAGAAAATTATTGATGGAGCACATCTTCAAACTACAGGAGTTTTGTAACA GCATGGTTAAACTCTGCATTGATGGATACGAATATGCCTACCTGAAGGCAATAGTACTCTTCAGTCCAGATCATCCAAGCCTAGAAAACA TGGAACAGATAGAGAAATTTCAGGAAAAGGCTTATGTGGAATTCCAAGATTATATAACCAAAACATATCCAGATGACACCTACAGGTTAT CCAGACTACTACTCAGATTGCCAGCTTTAAGACTGATGAATGCTACCATCACTGAAGAATTGTTTTTCAAAGGTCTCATTGGCAATATAC GAATTGACAGTGTTATCCCACATATTTTGAAAATGGAGCCTGCAGATTATAACTCTCAAATAATTGGTCACAGCATTTGAAAACTGTGAC TGCAGTGCTGTAAACTTAACTGTTCTTTGCCAGAACACAAGACACCAAATTGAACTCACTGCTTTTGAGGCATCTGGAAATTTTTACTTT AAAAAGTAACCAGAATCCAAGGTATTTTTATTTTAGCTTCCCTTAAGAATTTTTGAAGTGACTGGGCAGGCAGCAGAAATTAAATGAATT TTTCTTCCTGATTCCTTTAAATGAATATGAAACACTACAAATTTATTCTTGGTGAAGATGATACCTGAAGCTGTCACCTCTTGATTATCT AAACTAAGCGCTCATTCTATTTTATAAAACAAATAAATTAGTCTCTTTTTTCTGAATTGTGTTCTAGTCATATTTAACTTCATTATGAAC TAGTAAAAATACTTAATGGTCAGAAATCCCTAAGGAGTTAGTTCCTTGCATTTTACTCTGCCATAATAATTTTTGTTTAATTACCATATC AAAATAAGATTATTTTATGCTTACTGGTATAATGACAGTATTAGAACTATAGGAAATAATTGAATACATATTTTTTGTCTTCTCTAAATA TCATGGTGTCCCTTAGCATATACTACTCTCATTGCTGGCAGTGAGACAGGCCATTCATGATCTTAAGAGTTGCCATTTTTAATGTATATT ATTAGTTACAAGCACTTTATATAGCAGAAAATTGTTTTTGAGAATAAGCTAGTGTTGATATTTTAATATTTTTAGCTTACTGCTCGTGTT TTTGTTTTTGTTTTCGTTTATAGAGGTGGGTTTCACTGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTGATCCTGCCTCAGCCTC CCAAAGTACTGGGATTACAGGCGCGTGCCACCGTGCCTGGCCTACTGCTGTCTTTGAAAATAATAGAGACTAGCCAGGTGTAGTGGCTCA TGCCTATAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAATATAGCAAGACC TCGTCTCTGTAAAAAGAAAGAAAGTAATAAAGACTAATTGAGCCCAAAATGTTTCACTATTTCAAAAAAGATATTTAAATTGTTGCTCTT TCATTCCATAAAAAGGATCTGATCTCTCTCCCACTTTTCTGACCTGAGTTAGAGCTTCCCAAACCTGTCATGTATGGGTTTTAGCCAATT TCTTTTAGATCACTAAAAAAACTCACCCAATATGTCAAATAATGGATTTATCATAGCCAGTACATGTTCTCAAGGCAAGTTTAAACATTA TTTTGAAGCTATTGATAATTTTTTAAAATAAAGAAATATTCACTGATTTTTTTCACTGTAAAGCACGGGAGGGCTGCTTTAACAACAGTA TAAGAATCAGCCTGAAGCCTTGTTACTGCTACAACAAATTCATTTTAGACTCCTCGGATGTCTTCCACAGTAATTTATTCTTTTAGCAAA CCTGATACTGATAACTGTTTCTTTGCTTTGATTTCTTGATGAATTATTTTGGTATGTTTGTTGATTTTTAAAGCAAACACGGATAATGCA CTCAGAGTACATTTTTTGTAAAGATTTTTGCAATAGAAGAAAAGTGAAGTTTTTGTGGGGATGTGGATTTTATTGCTTACTACTTTATAG TAATCAAAAGTTTGAAAATATCAACTTACAGTCTTTACCAGTTTACTAAGGGAAACTTTTTTCCCTATTTAAAACATGATCTTAGTCAAC AATTTTATTTATAATTATCAGCTAAATTACATTTAGTATAATACTCAAATGGAAAAATCAGTAGTTTATACCTTTATAAATACAGTTTAG TAAGCCAAGGAATCAGGGAAATAATCCTTTAAAATAATGTACTAATAGTTAAGATGTTTCAGGTGTTTTTTCTGATTAAATTTGCTACTA TATTTGGAAGACTTTAAAACTATATTAAAATGTGACTTGCATTACAAATTTCTGTGTCTTACCAGTATATTTGTAAATATATTATTCATT |
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FusionGenePPI for IKBIP_NR2C1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IKBIP | ELAVL1, FBXO6, APP, HNRNPH1, SYNCRIP, NDUFB6, RPUSD4, TMED4, OXA1L, SRSF5, FLNA, PDCD6, SFXN2, KDM1A, KRT15, MYOG, TPM3, NUP62, TFIP11, C9orf16, CLEC12A, GPM6A, TTC29, CLEC11A, FAM63B, SCARA3, TCTN2, TCTN3, TCTN1, FOXI2, NF2, HYPK, TNIP1, C10orf32, CCDC53, PCNT, VPS52, MSR1, EXOC1, ABI1, NCKAP1, AGGF1, ATG5, ATG16L1, ABI2, LOH12CR1, CYFIP2, TRAF7, BLOC1S1, PAWR, ALX3, CDK5RAP2, PSMC5, BLOC1S2, EXOC4, COLEC12, FADS3, CYFIP1, FBXO28, ATP6V0D1, AP2S1, SPINK2, ANTXR2, PLEKHG6, DUSP22, SNAPIN, ARRDC3, RAN, PCDH9 | NR2C1 | AR, HDAC3, HDAC4, ESR1, PML, NUDT3, NR2C2, DNMT1, CHD4, HDAC1, HDAC2, RBBP4, RBBP7, MTA1, MTA2, TRIM28, KDM1A, NONO, SFPQ, PSPC1, SIN3A, HCFC1, RBM39, SMARCA4, RCOR1, MBD3, POLD3, FOXL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IKBIP_NR2C1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IKBIP_NR2C1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NR2C1 | C0014175 | Endometriosis | 1 | CTD_human |
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