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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17216

FusionGeneSummary for IGFN1_KANK1

check button Fusion gene summary
Fusion gene informationFusion gene name: IGFN1_KANK1
Fusion gene ID: 17216
HgeneTgene
Gene symbol

IGFN1

KANK1

Gene ID

91156

23189

Gene nameimmunoglobulin-like and fibronectin type III domain containing 1KN motif and ankyrin repeat domains 1
SynonymsEEF1A2BP1ANKRD15|CPSQ2|KANK
Cytomap

1q32.1

9p24.3

Type of geneprotein-codingprotein-coding
Descriptionimmunoglobulin-like and fibronectin type III domain-containing protein 1EEF1A2-binding protein 1KY-interacting protein 1eEF1A2 binding proteinKN motif and ankyrin repeat domain-containing protein 1ankyrin repeat domain-containing protein 15kidney ankyrin repeat-containing protein
Modification date2018051920180523
UniProtAcc

Q86VF2

Q14678

Ensembl transtripts involved in fusion geneENST00000295591, ENST00000335211, 
ENST00000451870, 
ENST00000382303, 
ENST00000489369, ENST00000382297, 
ENST00000382293, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 3 X 6=108
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGFN1 [Title/Abstract] AND KANK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKANK1

GO:0010977

negative regulation of neuron projection development

19171758

TgeneKANK1

GO:0030177

positive regulation of Wnt signaling pathway

16968744

TgeneKANK1

GO:0030837

negative regulation of actin filament polymerization

17996375|18458160

TgeneKANK1

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

19171758

TgeneKANK1

GO:1900028

negative regulation of ruffle assembly

19171758

TgeneKANK1

GO:2000393

negative regulation of lamellipodium morphogenesis

19171758


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DU-8163-01AIGFN1chr1

201191955

+KANK1chr9

734748

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000295591ENST00000382303IGFN1chr1

201191955

+KANK1chr9

734748

+
5CDS-3UTRENST00000295591ENST00000489369IGFN1chr1

201191955

+KANK1chr9

734748

+
5CDS-3UTRENST00000295591ENST00000382297IGFN1chr1

201191955

+KANK1chr9

734748

+
5CDS-3UTRENST00000295591ENST00000382293IGFN1chr1

201191955

+KANK1chr9

734748

+
Frame-shiftENST00000335211ENST00000382303IGFN1chr1

201191955

+KANK1chr9

734748

+
5CDS-3UTRENST00000335211ENST00000489369IGFN1chr1

201191955

+KANK1chr9

734748

+
5CDS-3UTRENST00000335211ENST00000382297IGFN1chr1

201191955

+KANK1chr9

734748

+
5CDS-3UTRENST00000335211ENST00000382293IGFN1chr1

201191955

+KANK1chr9

734748

+
intron-3CDSENST00000451870ENST00000382303IGFN1chr1

201191955

+KANK1chr9

734748

+
intron-3UTRENST00000451870ENST00000489369IGFN1chr1

201191955

+KANK1chr9

734748

+
intron-3UTRENST00000451870ENST00000382297IGFN1chr1

201191955

+KANK1chr9

734748

+
intron-3UTRENST00000451870ENST00000382293IGFN1chr1

201191955

+KANK1chr9

734748

+

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FusionProtFeatures for IGFN1_KANK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGFN1

Q86VF2

KANK1

Q14678

Involved in the control of cytoskeleton formation byregulating actin polymerization. Inhibits actin fiber formationand cell migration. Inhibits RhoA activity; the function involvesphosphorylation through PI3K/Akt signaling and may depend on thecompetetive interaction with 14-3-3 adapter proteins to sequesterthem from active complexes. Inhibits the formation of lamellipodiabut not of filopodia; the function may depend on the competetiveinteraction with BAIAP2 to block its association with activatedRAC1. Inhibits fibronectin-mediated cell spreading; the functionis partially mediated by BAIAP2. Inhibits neurite outgrowth.Involved in the establishment and persistence of cell polarityduring directed cell movement in wound healing. In the nucleus, isinvolved in beta-catenin-dependent activation of transcription.Potential tumor suppressor for renal cell carcinoma.{ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160,ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IGFN1_KANK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IGFN1_KANK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IGFN1MEOX2KANK1PPP1CA, GRK5, ENO1, SHMT2, MOV10, NXF1, EPB41L3, DYNLL1, KIF21A, ARRB2, PIP4K2A, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IGFN1_KANK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IGFN1_KANK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKANK1C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneKANK1C0023893Liver Cirrhosis, Experimental1CTD_human