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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17213

FusionGeneSummary for IGFBPL1_IGFBPL1

check button Fusion gene summary
Fusion gene informationFusion gene name: IGFBPL1_IGFBPL1
Fusion gene ID: 17213
HgeneTgene
Gene symbol

IGFBPL1

IGFBPL1

Gene ID

347252

347252

Gene nameinsulin like growth factor binding protein like 1insulin like growth factor binding protein like 1
SynonymsIGFBP-RP4|IGFBPRP4|bA113O24.1IGFBP-RP4|IGFBPRP4|bA113O24.1
Cytomap

9p13.1

9p13.1

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor-binding protein-like 1IGFBP-related protein 10insulin-like growth factor binding protein related protein 4insulin-like growth factor-binding-related protein 4insulin-like growth factor-binding protein-like 1IGFBP-related protein 10insulin-like growth factor binding protein related protein 4insulin-like growth factor-binding-related protein 4
Modification date2018032920180329
UniProtAcc

Q8WX77

Q8WX77

Ensembl transtripts involved in fusion geneENST00000377694, ENST00000377694, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: IGFBPL1 [Title/Abstract] AND IGFBPL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA613923IGFBPL1chr9

38408328

-IGFBPL1chr9

38406870

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000377694ENST00000377694IGFBPL1chr9

38408328

-IGFBPL1chr9

38406870

+

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FusionProtFeatures for IGFBPL1_IGFBPL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGFBPL1

Q8WX77

IGFBPL1

Q8WX77

IGF-binding proteins prolong the half-life of IGFs andhave been shown to either inhibit or stimulate the growthpromoting effects of the IGFs in cell culture. They alter theinteraction of IGFs with their cell surface receptors (Bysimilarity). May be a putative tumor suppressor protein.{ECO:0000250, ECO:0000269|PubMed:15845387}. IGF-binding proteins prolong the half-life of IGFs andhave been shown to either inhibit or stimulate the growthpromoting effects of the IGFs in cell culture. They alter theinteraction of IGFs with their cell surface receptors (Bysimilarity). May be a putative tumor suppressor protein.{ECO:0000250, ECO:0000269|PubMed:15845387}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IGFBPL1_IGFBPL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IGFBPL1_IGFBPL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IGFBPL1_IGFBPL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IGFBPL1_IGFBPL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource