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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17203

FusionGeneSummary for IGFBP5_SIAE

check button Fusion gene summary
Fusion gene informationFusion gene name: IGFBP5_SIAE
Fusion gene ID: 17203
HgeneTgene
Gene symbol

IGFBP5

SIAE

Gene ID

3488

54414

Gene nameinsulin like growth factor binding protein 5sialic acid acetylesterase
SynonymsIBP5AIS6|CSE-C|CSEC|LSE|YSG2
Cytomap

2q35

11q24.2

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor-binding protein 5IBP-5IGF-binding protein 5IGFBP-5sialate O-acetylesteraseH-Lsecytosolic sialic acid 9-O-acetylesterase homologsialic acid-specific acetylesterase II
Modification date2018052720180519
UniProtAcc

P24593

Q9HAT2

Ensembl transtripts involved in fusion geneENST00000233813, ENST00000263593, 
ENST00000545756, ENST00000525730, 
Fusion gene scores* DoF score11 X 13 X 4=57232 X 5 X 12=1920
# samples 1936
** MAII scorelog2(19/572*10)=-1.59001572844744
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(36/1920*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGFBP5 [Title/Abstract] AND SIAE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGFBP5

GO:0014912

negative regulation of smooth muscle cell migration

10766744

HgeneIGFBP5

GO:0017148

negative regulation of translation

15700281

HgeneIGFBP5

GO:0030336

negative regulation of cell migration

15700281

HgeneIGFBP5

GO:0043569

negative regulation of insulin-like growth factor receptor signaling pathway

10766744

HgeneIGFBP5

GO:0048662

negative regulation of smooth muscle cell proliferation

10766744

HgeneIGFBP5

GO:0071320

cellular response to cAMP

7559606

HgeneIGFBP5

GO:0071407

cellular response to organic cyclic compound

7559606

TgeneSIAE

GO:0005975

carbohydrate metabolic process

23308225


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-EL-A3MW-01AIGFBP5chr2

217536828

-SIAEchr11

124543777

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000233813ENST00000263593IGFBP5chr2

217536828

-SIAEchr11

124543777

-
5CDS-intronENST00000233813ENST00000545756IGFBP5chr2

217536828

-SIAEchr11

124543777

-
5CDS-intronENST00000233813ENST00000525730IGFBP5chr2

217536828

-SIAEchr11

124543777

-

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FusionProtFeatures for IGFBP5_SIAE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGFBP5

P24593

SIAE

Q9HAT2

IGF-binding proteins prolong the half-life of the IGFsand have been shown to either inhibit or stimulate the growthpromoting effects of the IGFs on cell culture. They alter theinteraction of IGFs with their cell surface receptors. Catalyzes the removal of O-acetyl ester groups fromposition 9 of the parent sialic acid, N-acetylneuraminic acid.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IGFBP5_SIAE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IGFBP5_SIAE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IGFBP5BAG6, THBS1, SPP1, ADAM12, FHL2, SERPINE1, VTN, IGFALS, IGF1, IGF2, LTBP1, LMNASIAEFBXO6, PTPRK, CPE, HLA-B, ENTPD6, NPTX1, CNTNAP3, MANEAL, OAF, TMEM30A, MR1, COCH, FAM162A, GPR98, GFPT2, MOXD1, LNPEP, PLXNB2, TCTN1, POC1A, NDST2, SGSH, TENM3, ERAP1, MANBA, ITGA8, TMEM2, LAMB2, FASTKD3, CHSY3, GDF11, DDX47, TMEM131, ARSK, ARSB, MBTPS1, COL18A1, MANEA, NAAA, RPP38, NRP2, PTGFRN, PLTP, KIAA1161, DCBLD2, SEPN1, GALNT7, TGFBR3, MAN2B2, TMEM132A, GALNS, NAGLU, CTSF, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IGFBP5_SIAE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IGFBP5_SIAE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGFBP5C0005695Bladder Neoplasm1CTD_human
HgeneIGFBP5C0043094Weight Gain1CTD_human
HgeneIGFBP5C1458155Mammary Neoplasms1CTD_human
TgeneSIAEC3150797AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 61UNIPROT