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Fusion gene ID: 17201 |
FusionGeneSummary for IGFBP5_RALGAPA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IGFBP5_RALGAPA2 | Fusion gene ID: 17201 | Hgene | Tgene | Gene symbol | IGFBP5 | RALGAPA2 | Gene ID | 3488 | 57186 |
| Gene name | insulin like growth factor binding protein 5 | Ral GTPase activating protein catalytic alpha subunit 2 | |
| Synonyms | IBP5 | AS250|C20orf74|bA287B20.1|dJ1049G11|dJ1049G11.4|p220 | |
| Cytomap | 2q35 | 20p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | insulin-like growth factor-binding protein 5IBP-5IGF-binding protein 5IGFBP-5 | ral GTPase-activating protein subunit alpha-2250 kDa substrate of AktRal GTPase activating protein, alpha subunit 2 (catalytic)RapGAPalpha2akt substrate AS250ral GTPase-activating protein alpha subunit 2 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P24593 | Q2PPJ7 | |
| Ensembl transtripts involved in fusion gene | ENST00000233813, | ENST00000202677, ENST00000495793, | |
| Fusion gene scores | * DoF score | 11 X 13 X 4=572 | 8 X 8 X 6=384 |
| # samples | 19 | 9 | |
| ** MAII score | log2(19/572*10)=-1.59001572844744 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IGFBP5 [Title/Abstract] AND RALGAPA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IGFBP5 | GO:0014912 | negative regulation of smooth muscle cell migration | 10766744 |
| Hgene | IGFBP5 | GO:0017148 | negative regulation of translation | 15700281 |
| Hgene | IGFBP5 | GO:0030336 | negative regulation of cell migration | 15700281 |
| Hgene | IGFBP5 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway | 10766744 |
| Hgene | IGFBP5 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 10766744 |
| Hgene | IGFBP5 | GO:0071320 | cellular response to cAMP | 7559606 |
| Hgene | IGFBP5 | GO:0071407 | cellular response to organic cyclic compound | 7559606 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI053318 | IGFBP5 | chr2 | 217541113 | - | RALGAPA2 | chr20 | 20500085 | - | ||
| ChiTaRS3.1 | BI053329 | IGFBP5 | chr2 | 217541113 | - | RALGAPA2 | chr20 | 20500085 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000233813 | ENST00000202677 | IGFBP5 | chr2 | 217541113 | - | RALGAPA2 | chr20 | 20500085 | - |
| intron-intron | ENST00000233813 | ENST00000495793 | IGFBP5 | chr2 | 217541113 | - | RALGAPA2 | chr20 | 20500085 | - |
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FusionProtFeatures for IGFBP5_RALGAPA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IGFBP5 | RALGAPA2 |
| IGF-binding proteins prolong the half-life of the IGFsand have been shown to either inhibit or stimulate the growthpromoting effects of the IGFs on cell culture. They alter theinteraction of IGFs with their cell surface receptors. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IGFBP5_RALGAPA2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IGFBP5_RALGAPA2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IGFBP5_RALGAPA2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IGFBP5_RALGAPA2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IGFBP5 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | IGFBP5 | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | IGFBP5 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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